Drug & supplement interaction

Alpha-gpc + Amlodipine Besylate

Amlodipine Besylate brand name: Norvasc.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Alpha-gpc and Amlodipine Besylate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Alpha-gpc and Amlodipine Besylate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amlodipine Besylate and Alpha-gpc in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Alpha-gpc safety at a glance

Alpha-gpc overall Use caution Generally well tolerated in studies, but long-term safety is not fully established.
Pregnancy Avoid Not enough safety information; avoid unless directed by your doctor.
Breastfeeding Avoid Not enough safety information; avoid unless directed by your doctor.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amlodipine Besylate and Alpha-gpc? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Amlodipine Besylate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Amlodipine Besylate is filed under 5 classifications — including calcium channel blockers, antihypertensive drugs, cytochrome p450 3a4 (cyp3a4) substrates. Alpha-gpc has documented interactions with 1 drug class — the most serious being scopolamine (transderm scop) (minor) — and none of Amlodipine Besylate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Alpha-gpc Does Interact With Other Medications

Alpha-gpc has 16 minor known drug interactions in our database — Amlodipine Besylate isn’t one of them. If you take anything else, check it against the full list below.

Minor 16 No known interaction 2,814 (incl. Amlodipine Besylate)
Taking anything else?

Check Another of Your Medications Against Alpha-gpc

Covers the 2,830 medications we’ve checked against Alpha-gpc. Pick one to open its full report.

What to actually watch for

What Alpha-gpc Itself Has Been Linked To

This is not an interaction — nothing below involves Amlodipine Besylate. It is the side-effect record for Alpha-gpc on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Alpha-gpc, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Fainting / Confusion Worth acting on Additional detail

    “Orally, alpha-GPC has been rarely associated with dizziness, excitation, headache, and insomnia. Alpha-GPC use for at least 2 months has also been associated with an elevated risk of stroke when compared with non-users or those who used alpha-GPC for less than 2 months.

    Intramuscularly, alpha-GPC has been rarely associated with confusion, excitation, fainting, headache, and insomnia.”

    Alpha-gpc · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 12102. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
    2. 108883. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.
  • Heartburn / Diarrhea / Vomiting / Nausea Additional detail

    “Orally, alpha-GPC has been rarely associated with diarrhea, heartburn, nausea, and vomiting.

    Intramuscularly, alpha-GPC has been rarely associated with diarrhea, heartburn, nausea, and vomiting.”

    Alpha-gpc · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 12102. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  • Trouble sleeping / Dizziness / Headache Additional detail

    Recorded for Alpha-gpc in the same Natural Medicines adverse-effect record shown under Fainting / Confusion above.

  • A skin rash Additional detail

    “Orally, some patients can experience skin rash. Intramuscularly, alpha-GPC can cause erythema at the injection site.”

    Alpha-gpc · Natural Medicines adverse-effect record, reported in erythema.

    2 sources cited
    1. 12102. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
    2. 12101. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.

Everything above comes from the Natural Medicines adverse-effect record for Alpha-gpc — expand a row for the licensed statement it rests on. We haven’t matched Amlodipine Besylate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Amlodipine Besylate.

Overlapping uses

What Amlodipine Besylate Is Prescribed For, and What Alpha-gpc Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Amlodipine Besylate is a prescription medicine with approved uses on its FDA label. Alpha-gpc is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Amlodipine Besylate is prescribed for: Amlodipine treats high blood pressure (hypertension) in adults and children aged 6–17 years. Lowering blood pressure reduces the risk of strokes and heart attacks. Sdamlo (oral solution) is specifically indicated for hypertension in adults and pediatric patients 6 years of age and older. Amlodipine also treats coronary artery disease in adults, including chronic stable angina (chest pain with exertion), vasospastic angina (Prinzmetal's or variant angina, caused by coronary artery spasms), and documented coronary artery disease in patients without heart failure or significantly reduced heart pumping function.

Alpha-gpc has been studied for:

  • Stroke studied, not established Alpha-gpc has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Alpha-gpc for stroke

    It is unclear if intramuscular or oral alpha-GPC is beneficial for preventing stroke or improving post-stroke outcomes.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Amlodipine Besylate on your own; if you are taking Alpha-gpc for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Alpha-gpc or Amlodipine Besylate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Alpha-gpc or Amlodipine Besylate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amlodipine Besylate

This page covers Alpha-gpc only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amlodipine Besylate page lists 232 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Coleus (major) and Grapefruit (major).

Open the Amlodipine Besylate interaction page

One more smart check

Taking Alpha-gpc as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,138 real supplement products containing Alpha-gpc, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Alpha-gpc. Even though Alpha-gpc itself has no known interaction with Amlodipine Besylate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Alpha-gpc and Amlodipine Besylate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alpha-gpc
Top 25%

#147 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amlodipine Besylate
Top 5%

#61 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alpha-gpc reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Alpha-gpc and Amlodipine Besylate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Alpha-gpc

What is Alpha-gpc?

Alpha-gpc
  • Memory and learning support
  • Age-related cognitive decline
  • Alzheimer's disease and dementia (under study)
  • Athletic and physical performance
  • Source of choline

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence in healthy people is limited. Talk to your pharmacist or doctor before starting it, especially if you take other medicines or have a health condition.

Synthesized compound; also found naturally in soy lecithin and small amounts in foods · Capsules, tablets, powder, liquid

An interaction check asks whether these two react with each other — it does not ask whether Alpha-gpc is a good idea for someone in your situation. Here is what our Alpha-gpc record says about it on its own.

Alpha-gpc: dosing

There is no official, standardized dose of Alpha-GPC for any condition. Doses used in research have varied depending on the purpose and the people studied.The safest approach is to follow the directions on the product label and not exceed them.

From our Alpha-gpc monograph — the full record covers uses, side effects and every documented interaction.

Read the full Alpha-gpc monograph & all interactions
Medication

About Amlodipine

What Is Amlodipine Used For?

Brand name: Norvasc

Amlodipine treats high blood pressure (hypertension) in adults and children aged 6–17 years. Lowering blood pressure reduces the risk of strokes and heart attacks. Sdamlo (oral solution) is specifically indicated for hypertension in adults and pediatric patients 6 years of age and older.

Amlodipine also treats coronary artery disease in adults, including chronic stable angina (chest pain with exertion), vasospastic angina (Prinzmetal's or variant angina, caused by coronary artery spasms), and documented coronary artery disease in patients without heart failure or significantly reduced heart pumping function.

Most-Reported Side Effects for Amlodipine Besylate

From FAERS, the FDA’s public side-effect reporting system (168,900 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 10,835 reports
Nausea 9,443 reports
Diarrhea 8,945 reports
Dyspnea 8,684 reports
Dizziness 7,742 reports
See full Amlodipine drug information
Keep checking

Other Drugs & Alpha-gpc

Browse every other medication we’ve checked against Alpha-gpc — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
16Minor
2,813No known interaction
16 Minor 2,813 No interaction
Minor

16 interactions

No interaction 2,813 drugs checked — show the list

We also checked Alpha-gpc against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,813 medications checked with no known interaction — see the full Alpha-gpc list.

See the full Alpha-gpc interactions page
See every supplement checked against Amlodipine Besylate, ranked by severity
Evidence & sources

Alpha-gpc References

The 4 references that drive our Alpha-gpc monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Alpha-gpc and Amlodipine Besylate Together: Common Questions

Is it safe to take Alpha-gpc with Amlodipine Besylate?
We do not list a known interaction between Alpha-gpc and Amlodipine Besylate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Alpha-gpc and Amlodipine Besylate used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Alpha-gpc in each. That is a conversation for your prescriber, especially if Amlodipine Besylate is being adjusted to a target.
How was the Alpha-gpc and Amlodipine Besylate combination checked?
Interactions in our licensed database are recorded against drug classes. Amlodipine Besylate is filed under 5 classifications, and Alpha-gpc has documented interactions with 1 drug class — none of Amlodipine Besylate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Alpha-gpc interact with any other medications?
Yes. Alpha-gpc has 16 documented drug interactions in our database — Amlodipine Besylate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Amlodipine Besylate interact with any supplements?
Yes. Amlodipine Besylate has documented interactions with 232 supplements in our database — Alpha-gpc is not one of them. The Amlodipine Besylate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Alpha-gpc monograph Uses, safety profile, and every drug interaction in one place Amlodipine drug information The full plain-English guide to this medication Amlodipine Besylate supplement interactions Every supplement checked against Amlodipine Besylate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amlodipine Besylate and Alpha-gpc?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.