Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

PEA Relief Ingredients & Drug Interactions

by Metagenics

PEA Relief label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PEA Relief against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PEA Relief is a dietary supplement by Metagenics with 4 active ingredients. Its ingredients are commonly taken for flavoring and culinary use, digestive complaints like bloating and indigestion, boosting absorption of other supplements.Based on those ingredients, 1,163 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Pepper, Clove bud Oils, organic broad spectrum Hemp extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against PEA Relief by Metagenics

Ask about any prescription or over-the-counter medication and we check it for interactions with PEA Relief by Metagenics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of PEA Relief by Metagenics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (3.75 mg) without saying how much of each component you get.

PEA Relief contains 4 active ingredients. The product is built around palmitoylethanolamide (PEA), a compound your body naturally produces that's being studied for joint discomfort and other pain-related conditions.

It also includes black pepper and clove bud oils — both traditional culinary spices added for their potential to support the body's response to inflammation — and a broad-spectrum hemp extract. These are delivered in a softgel capsule along with hemp oil, sunflower lecithin, and other inactive ingredients that make up the capsule shell and help absorption.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support bodily comfort and quality of life.
  • We looked for evidence on: Neuropathic pain, Sciatica, Complex regional pain syndrome, Fibromyalgia, Joint pain, Osteoarthritis — and 4 related terms.
  • The strongest evidence on file: Palmitoylethanolamide (pea) is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA).
  • Also on file: Palmitoylethanolamide (pea) is rated "Insufficient Reliable Evidence To Rate" for Fibromyalgia, Neuropathic pain, Complex regional pain syndrome, Sciatica.

The evidence for what PEA Relief does is limited. Palmitoylethanolamide (PEA) is possibly effective for osteoarthritis, though the data aren't robust.

For other uses — carpal tunnel syndrome, migraine headache, autism spectrum disorder, and cannabis use disorder — there isn't enough reliable evidence to rate it. Black pepper, clove, and hemp extract all show insufficient reliable evidence for the conditions most people might think of them for (like general inflammation, pain, or cough), so we can't claim the product works for those on the basis of the studies we hold.

The evidence, ingredient by ingredient Black Pepper Clove Hemp Palmitoylethanolamide (pea)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The ingredients are generally well tolerated at the doses used in supplements. Black pepper can cause a burning aftertaste, heartburn, or reduced taste perception orally, and rarely triggers an allergic reaction in sensitive people.

Clove is safe as a food spice but concentrated clove oil can be toxic even in small amounts (5–10 mL can harm children), and topically it may cause burning, contact dermatitis, or mouth sores. Hemp extract is generally safe in food amounts; rare cases of allergic reaction and hepatitis have been reported.

PEA may cause nausea but is otherwise well tolerated. Long-term safety data for PEA and hemp extracts are limited.

For pregnancy: Black pepper is likely safe, but clove's safety in pregnancy is unclear — the data show conflicting ratings. Hemp extract and PEA lack enough safety information for pregnancy and breastfeeding, so talk with your doctor or pharmacist before using during these times.

Side effects, ingredient by ingredient Black Pepper Clove Hemp Palmitoylethanolamide (pea)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Clove, Black Pepper, Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,164 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking PEA Relief, check with your doctor or pharmacist if you take anti-seizure drugs (phenytoin), propranolol or other beta-blockers, antidiabetes medications, blood thinners or anticoagulants, blood pressure drugs, or any medication broken down by your liver — a broad category that includes many common prescriptions. The most serious documented risk is with seizure medications and blood pressure drugs, but the clove and hemp content mean many other drug classes warrant review.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

PEA Relief may be worth considering if you're looking for a multi-ingredient approach to joint comfort and you've confirmed your medications won't conflict with it — especially the black pepper and clove content. If you take any prescription drugs, blood pressure meds, blood thinners, diabetes medications, or anti-seizure drugs, you'll need to check those against the interactions listed here before starting.

Talk with your doctor or pharmacist about whether it's right for your situation and to discuss any side effects you experience.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PEA Relief, straight from the product label.

Brand Metagenics
Barcode (UPC) 755571958556
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 268108
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PEA Relief by Metagenics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s), 2 Softgel(s)
Maximum serving Sizes:
1 Softgel(s), 2 Softgel(s)
Servings per container
60
UPC/BARCODE
755571958556
IngredientAmount% DV
Total Fat0 NP, 0.5 Gram(s)1%
Proprietary Blend3.75 mg, 7.5 mg--
Calories0 NP, 5 Calorie(s)--
Black Pepper0 NP, 0 NP--
Clove bud Oils0 NP, 0 NP--
organic broad spectrum Hemp extract70 mg, 140 mg--
Levagen Palmitoylethanolamide300 mg, 600 mg--

Other ingredients: Palmitoylethanolamide powder, Softgel shell, organic Hemp Oil blend, organic Hemp seed Oil, Sunflower Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

PEA has been shown to support bodily comfort and increase subjective measures of quality of life. Patent-pending PEA Relief is a unique blend of Palmitoylethanolamide (PEA) and organic, full-spectrum hemp oil extract shown in a preclinical study to enhance the presence of PEA in the blood circulation.

Palmitoylethanolamide (PEA) with full-spectrum hemp

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one softgel twice daily or as directed by your healthcare practitioner.

Formulation

This product is non-GMO and gluten-free. GF Certified Gluten-free

Precautions

Caution: If pregnant, nursing, or taking medication, consult your healthcare practitioner before use.

Keep out of the reach of children.

Notice: This product is sourced from industrial hemp, which does not exceed 0.3% THC concentration (dry weight).

Practitioner exclusive

Storage

Storage: Keep tightly closed in a cool, dry place.

General Statements

Based on government limit of detection protocols and default maximum residue limits (MRLs), which are usually 10 parts per billion (ppb) for all pesticides.

Formerly Hemp Advantage Plus

Seals/Symbols

GF Certified Gluten-free

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Levagen+ is a trademark of Gencor, used under License. Patent pending.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PEA Relief by Metagenics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PEA Relief label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PEA Relief by Metagenics

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

3.75 mg per serving

Organic broad spectrum Hemp extract

Interacts with
938 drugs
70 mg per serving

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...

Organic broad spectrum Hemp extract monograph & interactions

Levagen Palmitoylethanolamide

No known
interactions
300 mg per serving

Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...

Levagen Palmitoylethanolamide monograph & interactions

Other (inactive) ingredients: Palmitoylethanolamide powder, Softgel shell, Organic Hemp Oil blend, Organic Hemp seed Oil, Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

PEA Relief by Metagenics Drug Interactions

Want to check YOUR meds against PEA Relief?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,163Drugs
1,047 Moderate 116 Minor

Ingredients driving the most interactions

Black Pepper 1,019
Clove bud Oils 977
organic broad spectrum Hemp extract 938

Individual Drug Interactions

The ingredients in PEA Relief interact with 1,163 drugs. Click any drug to see the details.

3 of the 4 ingredients in PEA Relief interact with drugs. Each result below shows which ingredient is responsible. Black Pepper Clove bud Oils organic broad spectrum Hemp extract

Each ingredient & the kinds of drugs it affects

For each ingredient in PEA Relief with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Pepper17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Black Pepper full monograph & interactions

Clove bud Oils7 drug types · 977 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Clove bud Oils full monograph & interactions

organic broad spectrum Hemp extract6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
organic broad spectrum Hemp extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PEA Relief, from the product label.

Metagenics

See all Metagenics products
Name
Metagenics
City
Gig Harbor
State
WA
ZipCode
98332
Phone Number
800 692 9400
Web Address
metagenics.com
Pharmacist Counseling Corner

PEA Relief by Metagenics: Common Questions

Does PEA Relief by Metagenics interact with any medications?
Yes. Based on its ingredients, PEA Relief has a known interaction with 1,163 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PEA Relief contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is PEA, and why is it in this product?
PEA stands for palmitoylethanolamide — a compound your body makes naturally that's being studied for osteoarthritis and certain pain conditions. Metagenics includes it as the core active ingredient in this formula.
Is this product safe if I'm pregnant or breastfeeding?
Black pepper is likely safe, but we don't have enough data on the safety of PEA or hemp extract during pregnancy or breastfeeding to say either way. Talk with your doctor or pharmacist before taking it if you're pregnant or nursing — they know your full picture and can give you personalized advice.
Can I use this if I'm taking a blood thinner like warfarin?
You'll need to check with your doctor or pharmacist first. Black pepper and clove may affect how your liver breaks down warfarin and similar drugs, and hemp extract theoretically may increase bleeding risk. Don't start this product without running it past your own healthcare provider.
What are the most common side effects?
Black pepper may cause a burning aftertaste or heartburn; clove topically can cause burning or irritation; and PEA has rarely caused nausea. Most people don't experience side effects at supplement doses, but if you do, tell your pharmacist.
Is there any evidence this actually works for pain or joint problems?
PEA is possibly effective for osteoarthritis, but the evidence isn't strong. For other uses, we don't hold reliable evidence that this product works. Talk with your doctor about whether it might be worth trying for your specific situation.
Does this contain any fillers or artificial ingredients?
The inactive ingredients are palmitoylethanolamide powder, the softgel shell, hemp oil blend, hemp seed oil, and sunflower lecithin — all listed on the label. There's no hidden ingredient list, but these are support materials rather than active ones.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PEA Relief label
Go deeper

The Full Monographs Behind PEA Relief’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Clove

Interacts with 977 drugs

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...

Read the full Clove monograph → Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph → Herb & supplement monograph

Palmitoylethanolamide (pea)

Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it may help certain types of chronic and ne...

Read the full Palmitoylethanolamide (pea) monograph →
Sources

Sources & How We Checked

PEA Relief's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 71 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Pepper 29 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
  4. Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
  5. Cohle SD, Trestrail JD III, Graham MA, et al. Fatal pepper aspiration. Am J Dis Child 1988;142:633-6. PubMed
  6. Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. PubMed
  7. Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet 2001;26:241-7. PubMed
  8. Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6.
  9. Munakata, M., Kobayashi, K., Niisato-Nezu, J., Tanaka, S., Kakisaka, Y., Ebihara, T., Ebihara, S., Haginoya, K., Tsuchiya, S., and Onuma, A. Olfactory stimulation using black pepper oil facilitates oral feeding in pediatric patients receiving long-term en
  10. Myers, B. M., Smith, J. L., and Graham, D. Y. Effect of red pepper and black pepper on the stomach. Am J Gastroenterol 1987;82(3):211-214.
  11. Raghavendra, R. H. and Naidu, K. A. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot.Essent.Fatty Acids 2009;81(1):73-78. PubMed
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See these in context on the Black Pepper monograph →

Clove 26 references
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See these in context on the Clove monograph →

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
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  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
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See these in context on the Hemp monograph →

Palmitoylethanolamide (pea) 4 references
  1. Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
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See these in context on the Palmitoylethanolamide (pea) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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