Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Ultra Flora IB Ingredients & Drug Interactions

by Metagenics

Ultra Flora IB label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Flora IB against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultra Flora IB is a dietary supplement by Metagenics with 2 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus NCFM. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultra Flora IB by Metagenics

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Flora IB by Metagenics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultra Flora IB by Metagenics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “A 50:50 Blend” is a proprietary blend — the label gives one combined amount (60,000,000,000 Live Organism(s)) without saying how much of each component you get.

Ultra Flora IB contains two active probiotic strains: Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07. These are live microorganisms intended to support your gut flora.

The capsule also contains inactive ingredients including microcrystalline cellulose, magnesium stearate, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: relieve bowel irritation and abdominal discomfort.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Radiation-induced diarrhea, Lactose intolerance, and more.

Lactobacillus acidophilus is rated possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. It's rated possibly ineffective for atopic disease, and the evidence is insufficient to rate it for acute respiratory distress syndrome.

We have no effectiveness data on file for Bifidobacterium lactis Bi-07.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects like mild bloating, gas, abdominal discomfort, or diarrhea can occur when taking it with other probiotics, though these are uncommon.

Because it contains live organisms, there's a theoretical concern about infection in people with severely weakened immune systems — check with your doctor before use. We hold no pregnancy or breastfeeding safety data for either ingredient in this product.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your antibiotic medications before taking this product (Moderate severity interaction). We could not check Bifidobacterium lactis Bi-07 against our database, so ask your pharmacist about any other prescriptions you're on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ultra Flora IB may be worth considering if you have IBS, antibiotic-associated diarrhea, or certain gut infections — the evidence supports those uses. Don't take it at the same time as antibiotics; separate them by a few hours.

If you're on any medications, check them against our tool first, and ask your doctor before starting if you have a weakened immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Flora IB, straight from the product label.

Brand Metagenics
Barcode (UPC) 755571911957
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2013
DSLD ID 27789
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Flora IB by Metagenics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
755571911957
IngredientAmount% DV
Lactobacillus acidophilus NCFM0 NP--
Bifidobacterium lactis Bi-070 NP--
A 50:50 Blend60000000000 Live Organism(s)--

Other ingredients: Microcrystalline Cellulose, Bifidobacterium lactis, Lactobacillus acidophilus, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

NOTICE: For maximum stability and viability, keep this product refrigerated.

General Statements

Genetic Potential Through Nutrition

Probiotic Relief for Abdominal Discomfort 60 BILLION ORGANISMS PER CAPSULE GUARANTEED

LUL111G

F1381B EXP 09/11

PROD. UFIB30

The ID Guarantee: Ultra Flora IB provides guaranteed purity, clinical reliability, and predicted safety through science identification of strains with established health benefits. In vitro analysis of each strain for acid tolerance and cell adherence assures potency and high viability.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Ultra Flora IB(TM) is an enhanced potency probiotic formula in a non-dairy powder designed to help relieve bowel irritation and related functional discomforts. By helping to maintain a healthy balance of intestinal microflora, this formula may help support healthy intestinal motility and help address abdominal discomfort, bloating, and cramping.

Bifidobacteria and Lactobacillus probiotic strains consume milk-derived nutrients as a food source during one step of the fermentation process. No additional milk-derived nutrients were added outside of this fermentation step.

NCFM(R) is a trademark of the North Carolina Dairy Foundation

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take one capsule one to two times daily or as directed by your healthcare practitioner.

Precautions

CAUTION: This product may not be suitable for individuals with severe milk or soy allergies.

Keep out of the reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Flora IB by Metagenics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Flora IB label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Flora IB by Metagenics

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

A 50:50 Blend

60000000000 Live Organism(s) per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Bifidobacterium lactis, Lactobacillus acidophilus, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Flora IB by Metagenics Drug Interactions

Want to check YOUR meds against Ultra Flora IB?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus NCFM 182

Individual Drug Interactions

The ingredients in Ultra Flora IB interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Ultra Flora IB interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus NCFM

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Flora IB with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus NCFM1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus NCFM full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Flora IB, from the product label.

Metagenics

See all Metagenics products
Name
METAGENICS, INC. Makers of Professional Quality Supplements
Street Address
100 Ave. La Pata
City
San Clemente
State
CA
ZipCode
92673
Web Address
www.metagenics.com
Pharmacist Counseling Corner

Ultra Flora IB by Metagenics: Common Questions

Does Ultra Flora IB by Metagenics interact with any medications?
Yes. Based on its ingredients, Ultra Flora IB has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Flora IB contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Ultra Flora IB with my antibiotic?
Not at the same time. Antibiotics kill the live organisms in this probiotic, so it won't work as intended. Ask your pharmacist how far apart to space them — usually a few hours is enough.
What's the difference between these two probiotic strains?
Both are beneficial bacteria that live in your gut. Lactobacillus acidophilus has research supporting it for IBS and antibiotic-related diarrhea. We don't have effectiveness data on file for Bifidobacterium lactis Bi-07.
Will this cause side effects?
Most people tolerate it well. A small number of people experience mild gas, bloating, or belly discomfort, especially when combining probiotics. Serious infections are very rare and mainly a concern if your immune system is severely weakened.
Is it safe to take during pregnancy or while breastfeeding?
We don't have safety data on file for either ingredient during pregnancy or breastfeeding. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
How does this help with IBS?
Lactobacillus acidophilus is rated possibly effective for irritable bowel syndrome, meaning the research shows promise but isn't definitive yet. It works by supporting your natural gut bacteria balance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultra Flora IB is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Flora IB label
Go deeper

The Full Monographs Behind Ultra Flora IB’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Ultra Flora IB's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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