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Dietary supplement

Pediacalm Ingredients & Drug Interactions

by LEV Laboratories

Pediacalm label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pediacalm against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pediacalm is a dietary supplement by LEV Laboratories with 1 active ingredient. Its ingredients are commonly taken for digestive upset and bloating, infant colic, menstrual cramps.Based on those ingredients, 740 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fennel seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pediacalm by LEV Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Pediacalm by LEV Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pediacalm by LEV Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pediacalm is a liquid supplement containing one active ingredient: fennel seed oil. Fennel has a long history as a culinary ingredient and is traditionally used to support digestive comfort and other wellness purposes.

The product also contains inactive ingredients—distilled water, polysorbate 80 (a solubilizer), and sodium benzoate (a preservative)—that give the liquid its form and shelf stability.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Help alleviate excessive crying associated with colic.
  • We looked for evidence on: Colic.
  • The closest evidence on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Colic (Natural Medicines).

The evidence for fennel seed oil is mixed and depends on the condition. For dysmenorrhea (painful periods), fennel is rated possibly effective.

For bronchitis, anxiety, nocturnal enuresis (bedwetting), and cholera, the reliable evidence to rate its effectiveness simply isn't there yet. That means we don't have enough solid data in our records to say whether it works for those uses, not that it doesn't work—just that more research is needed.

The evidence, ingredient by ingredient Fennel

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fennel seed oil is generally well tolerated when used as a food, but concentrated supplements need more caution. The most common side effects from oral use are mild gastrointestinal discomfort, sun sensitivity (photosensitivity), and allergic reactions in people sensitive to fennel.

Rarely, seizures have been reported. Some people may also experience bronchial asthma symptoms.

During pregnancy, fennel in medicinal or concentrated amounts is rated possibly unsafe because of limited safety data and its hormone-like effects—food amounts are likely fine, but this product is a concentrate. While breastfeeding, food amounts are probably okay, but medicinal doses and fennel essential oil haven't been well studied, so play it safe and talk with your pediatrician or pharmacist.

Side effects, ingredient by ingredient Fennel

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Fennel.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 741 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before giving Pediacalm to your child, double-check with your pediatrician or pharmacist if they're taking any blood thinners or antiplatelet drugs (Moderate risk of increased bleeding), birth control or hormone replacement therapy (Moderate risk of reduced effectiveness), liver-metabolized medications like certain CYP3A4 substrates (Moderate risk of higher drug levels), ciprofloxacin/Cipro (Moderate risk of reduced antibiotic effectiveness), or tamoxifen/Nolvadex (Moderate risk of reduced cancer drug effectiveness).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pediacalm is a single-ingredient fennel seed oil product that has good evidence for possibly helping with painful periods, though the evidence for other uses isn't established. It's generally well tolerated orally, but its estrogenic activity and potential to thin the blood mean you'll want to check all your child's medications—especially blood thinners, birth control, hormone therapy, and certain antibiotics—with your pediatrician or pharmacist before starting.

Avoid it during pregnancy and be cautious if breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pediacalm, straight from the product label.

Brand LEV Laboratories
Barcode (UPC) 696344100102
Net contents 6 oz.; 177 cc
Market status On market
Date entered into DSLD Dec 23, 2011
DSLD ID 3247
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Infants/Baby (0 - 1 Year)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pediacalm by LEV Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 fl. Oz.
Maximum serving Sizes:
0.25 fl. Oz.
UPC/BARCODE
696344100102
IngredientAmount% DV
Fennel seed Oil3.75 mg--

Other ingredients: distilled Water, Polysorbate 80, Sodium Benzoate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Pediacalm is a ready to drink product. Do not add water.

Dosage: 7.5 ml (1/4 fluid oz) of Pediacalm before feeding up to 5 times a day. Do not exceed 60ml (2 fluid oz) a day. Use a graduated dropper, give baby three, 2.5ml dropperfuls by mouth.

Precautions

Do not add water.

Consult physician before use. Do not use if protective seal is broken, damaged or has been tampered with in any way.

Brand IP Statement(s)

Patent Pending

General Statements

Developed by a pediatrician

Helps alleviate excessive crying associated with colic

6oz 5oz 4oz 3oz 2oz 1oz

FDA Statement of Identity

Infant Dietary Supplement

FDA Disclaimer Statement

The statements on this label have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pediacalm by LEV Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pediacalm label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pediacalm by LEV Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.25 fl. Oz. Dosage formLiquid Amounts shown are per serving.

Fennel seed Oil

Interacts with
740 drugs
3.75 mg per serving

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some sm...

Fennel seed Oil monograph & interactions

Other (inactive) ingredients: Distilled Water, Polysorbate 80, Sodium Benzoate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pediacalm by LEV Laboratories Drug Interactions

Want to check YOUR meds against Pediacalm?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
740Drugs
740 Moderate

Ingredients driving the most interactions

Fennel seed Oil 740

Individual Drug Interactions

The ingredients in Pediacalm interact with 740 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pediacalm interact with drugs. Each result below shows which ingredient is responsible. Fennel seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Pediacalm with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Fennel seed Oil6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pediacalm, from the product label.

LEV Laboratories

See all LEV Laboratories products
Name
LEV LABORATORIES LTD
Street Address
PO BOX 528
City
GLENCOE
State
IL
Pharmacist Counseling Corner

Pediacalm by LEV Laboratories: Common Questions

Does Pediacalm by LEV Laboratories interact with any medications?
Yes. Based on its ingredients, Pediacalm has a known interaction with 740 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pediacalm contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I give this to my child if they take birth control?
No—fennel seed oil may reduce how well birth control works by interfering with estrogen receptors. Check with your child's doctor or pharmacist before combining them.
Is fennel seed oil safe during pregnancy?
No, medicinal or concentrated amounts are rated possibly unsafe in pregnancy because of limited safety data and fennel's hormone-like effects. Food amounts are likely fine, but this product is a concentrate—talk with your obstetrician before use.
What's fennel seed oil actually used for?
Fennel seed oil has possibly effective evidence for dysmenorrhea (painful periods). The evidence for bronchitis, anxiety, bedwetting, and cholera isn't established yet in our data.
What are the most common side effects?
Most people tolerate fennel seed oil well orally. The most common side effects are mild—gastrointestinal discomfort, sun sensitivity, and allergic reactions in sensitive individuals. Rarely, seizures or asthma symptoms have been reported.
Will this interfere with antibiotics like ciprofloxacin?
Yes. Fennel may reduce how much of ciprofloxacin (Cipro) your body absorbs and lowers its effectiveness. Check with your pharmacist or doctor if your child is taking this antibiotic.
What's in this product besides the active ingredient?
Pediacalm contains distilled water, polysorbate 80 (a solubilizer to keep it liquid), and sodium benzoate (a preservative). These are inactive ingredients that support the formulation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pediacalm label
Go deeper

The Full Monographs Behind Pediacalm’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph →
Sources

Sources & How We Checked

Pediacalm's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
  4. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
  5. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  6. Rosti L, Nardini A, Bettinelli ME, Rosti D. Toxic effects of a herbal tea mixture in two newborns. Acta Paediatrica 1994;83:683. PubMed
  7. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
  8. Tognolini, M., Ballabeni, V., Bertoni, S., Bruni, R., Impicciatore, M., and Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol.Res 2007;56(3):254-260. PubMed
  9. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
  10. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  11. Subehan, Zaidi, S. F., Kadota, S., and Tezuka, Y. Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. J Agric.Food Chem. 12-12-2007;55(25):101 PubMed
  12. LEVY, S. B. Bronchial asthma due to ingestion of fennel and fennel seed. Ann.Allergy 1948;6(4):415.
  13. Ottolenghi, A., De Chiara, A., Arrigoni, S., Terracciano, L., and De Amici, M. [Diagnosis of food allergy caused by fruit and vegetables in children with atopic dermatitis]. Pediatr Med Chir 1995;17(6):525-530.
  14. Trabace L, Tucci P, Ciuffreda L, et al. "Natural" relief of pregnancy-related symptoms and neonatal outcomes: above all do no harm. J Ethnopharmacol. 2015;174:396-402. PubMed
  15. Denaxa D, Arkwright PD. Fennel as a cause of immediate hypersensitivity to toothpaste. Ann Allergy Asthma Immunol. 2020;125(1):99-100. PubMed
  16. Lee HW, Ang L, Lee MS, Alimoradi Z, Kim E. Fennel for reducing pain in primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. Nutrients 2020;12(11):3438. PubMed
  17. Mathew T, John SK, Javali M, Vasireddy M, Nadig R, Sarma GRK. Substance use related cluster headache: A case series. Headache 2022;62(7):908-910. PubMed

See these in context on the Fennel monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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