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Dietary supplement

Pennyroyal 450 mg Ingredients & Drug Interactions

by TerraVita Premium Collection

Pennyroyal 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pennyroyal 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pennyroyal 450 mg is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for digestive upset, menstrual cramps, inducing menstruation or abortion (dangerous).Based on those ingredients, 69 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pennyroyal. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pennyroyal 450 mg by TerraVita Premium Collection

Ask about any prescription or over-the-counter medication and we check it for interactions with Pennyroyal 450 mg by TerraVita Premium Collection — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pennyroyal 450 mg by TerraVita Premium Collection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pennyroyal at 450 mg per capsule. Pennyroyal is an herb traditionally used for gallbladder complaints, gout, colds, and other conditions, though the evidence supporting those uses isn't established in our data.

The capsule itself is made from gelatin and water.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pennyroyal product and its label doesn't state a use — see Pennyroyal's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that pennyroyal works for gallbladder disease, gout, insect repellent, colds, pneumonia, or canker sores. For all of those uses, the data rates pennyroyal as having insufficient reliable evidence.

The evidence, ingredient by ingredient Pennyroyal

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pennyroyal, especially the essential oil form, carries serious safety concerns. It's hepatotoxic—meaning it can damage your liver—and has caused liver failure and death in some cases.

The main toxic compounds are pulegone and its metabolite menthofuran. Common side effects from pennyroyal leaf tea include dizziness, nausea, and stomach cramping; the essential oil is tied to far more severe effects.

Topically, pennyroyal essential oil can trigger rashes and dermatitis. This product is not safe during pregnancy or breastfeeding.

Pennyroyal can cause miscarriage and severe poisoning and has been linked to death in pregnant people. Don't use it if you're pregnant, trying to become pregnant, or nursing.

Side effects, ingredient by ingredient Pennyroyal

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pennyroyal.
  • The most serious interaction on file is rated Moderate.
  • For scale: 69 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check whether you take acetaminophen (pain relievers, fever reducers, cold medicines, allergy products, and combination drugs often contain it). That's the documented Moderate-severity interaction.

Before you start, use the medication checker on this page to review all your prescriptions and over-the-counter drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Given the lack of proven effectiveness and serious toxicity risks—especially liver damage—most people don't need pennyroyal. If you're considering it for any condition, talk to your pharmacist or doctor first.

If you take acetaminophen, avoid this product entirely without medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pennyroyal 450 mg, straight from the product label.

Brand TerraVita Premium Collection
Barcode (UPC) 064435136956
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 286670
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pennyroyal 450 mg by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
064435136956
IngredientAmount% DV
Pennyroyal450 mg--

Other ingredients: Gelatin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Copyright 2005 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Suggested/Recommended/Usage/Directions

Directions Take 1 capsule 3 times daily, with meals.

General Statements

TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.

Please recycle!

FDA Disclaimer Statement

Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pennyroyal 450 mg by TerraVita Premium Collection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pennyroyal 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pennyroyal 450 mg by TerraVita Premium Collection

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Pennyroyal

Interacts with
69 drugs
450 mg per serving

Pennyroyal is a mint-family plant whose essential oil is highly toxic and has caused serious poisonings and deaths, especially when used to try to bri...

Pennyroyal monograph & interactions

Other (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pennyroyal 450 mg by TerraVita Premium Collection Drug Interactions

Want to check YOUR meds against Pennyroyal 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
69Drugs
69 Moderate

Ingredients driving the most interactions

Pennyroyal 69

Individual Drug Interactions

The ingredients in Pennyroyal 450 mg interact with 69 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pennyroyal 450 mg interact with drugs. Each result below shows which ingredient is responsible. Pennyroyal

Each ingredient & the kinds of drugs it affects

For each ingredient in Pennyroyal 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pennyroyal1 drug type · 69 drugs

Acetaminophen (Tylenol, Others)

Concomitant use of pennyroyal essential oil and acetaminophen might increase the risk of acetaminophen-induced hepatotoxicity.
Pennyroyal is hepatotoxic and depletes hepatic glutathione levels in a similar manner to acetaminophen. A case report describes hepatic failure in a female who took pennyroyal and acetaminophen concurrently.

Likelihood Possible Evidence D
Pennyroyal full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pennyroyal 450 mg, from the product label.

TerraVita Premium Collection

See all TerraVita Premium Collection products
Name
TerraVita Fine Whole Herbs
City
Brampton
State
Ontario
Pharmacist Counseling Corner

Pennyroyal 450 mg by TerraVita Premium Collection: Common Questions

Does Pennyroyal 450 mg by TerraVita Premium Collection interact with any medications?
Yes. Based on its ingredients, Pennyroyal 450 mg has a known interaction with 69 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pennyroyal 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is pennyroyal safe during pregnancy?
No. The safety data rates pennyroyal as likely unsafe in pregnancy. It can cause miscarriage, severe poisoning, and death. Do not use this product if you're pregnant or trying to become pregnant.
Is pennyroyal safe while breastfeeding?
No. The safety data rates pennyroyal as likely unsafe while breastfeeding. Its toxic compounds make it inappropriate for nursing. Talk to your doctor before taking any herbal products if you're breastfeeding.
What are the side effects?
Pennyroyal leaf tea typically causes dizziness, nausea, and stomach cramping. The essential oil form is tied to much more serious effects, including liver failure. Applied to skin, it can cause rashes and dermatitis.
Does pennyroyal actually work for what it claims?
The evidence we hold doesn't establish that it works for gallbladder disease, gout, colds, pneumonia, canker sores, or as an insect repellent. For all of those uses, we rate the evidence as insufficient.
Why is pennyroyal dangerous with acetaminophen?
Both pennyroyal and acetaminophen damage your liver in similar ways, and they deplete the same protective compound (glutathione) in liver cells. Taking them together significantly raises the risk of serious liver injury, and at least one person has developed liver failure from that combination.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pennyroyal 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pennyroyal 450 mg label
Go deeper

The Full Monographs Behind Pennyroyal 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pennyroyal

Interacts with 69 drugs

Pennyroyal is a mint-family plant whose essential oil is highly toxic and has caused serious poisonings and deaths, especially when used to try to bring on a period or end a pregnancy. There...

Read the full Pennyroyal monograph →
Sources

Sources & How We Checked

Pennyroyal 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pennyroyal 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Bakerink JA, Gospe SM Jr, Dimand RJ, Eldridge MW. Multiple organ failure after ingestion of pennyroyal oil from herbal tea in two infants. Pediatrics 1996;98:944-7. DOI
  5. Sudekum M, Poppenga RH, Raju N, Braselton WE Jr. Pennyroyal oil toxicosis in a dog. J Am Vet Med Assoc 1992;200:817-8.. DOI
  6. Anderson IB, Mullen WH, Meeker JE, et al. Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature. Ann Intern Med 1996;124:726-34. PubMed
  7. Sullivan JB Jr, Rumack BH, Thomas H Jr, et al. Pennyroyal oil poisoning and hepatotoxicity. JAMA 1979;242:2873-4. DOI
  8. Fozard J, Hieger M. Hepatic failure from pennyroyal tea interaction with medications metabolized by the cytochrome P450 enzymes. Am J Ther 2019 Aug 13. doi: 10.1097/MJT.0000000000001052. [Epub ahead of print]. PubMed

See these in context on the Pennyroyal monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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