Peptiva + Prodigest Ingredients & Drug Interactions
by Peptiva
What is this page for?
First and foremost: checking Peptiva + Prodigest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Peptiva + Prodigest is a dietary supplement by Peptiva with 18 active ingredients. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 488 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke extract and Ginger extract, Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Peptiva + Prodigest by Peptiva
Ask about any prescription or over-the-counter medication and we check it for interactions with Peptiva + Prodigest by Peptiva — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Peptiva + Prodigest by Peptiva
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.
Why this rating?
- The label discloses an exact amount for 1 of its 18 active ingredients.
- “Vegetarian Digestive Enzyme Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 2 of the 6 matched ingredients can interact with medications — Artichoke, Bromelain.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
- For scale: 488 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
- Pregnancy & breastfeeding safety ratings cover 6 of 6.
- General safety write-ups exist for 6 of 6.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 8 of 18 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Peptiva + Prodigest, straight from the product label.
| Brand | Peptiva |
|---|---|
| Barcode (UPC) | 855710002543 |
| Net contents | 30 Vegetarian Capsule(s) |
| Market status | Off market |
| Date entered into DSLD | Feb 25, 2019 |
| DSLD ID | 199906 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Peptiva + Prodigest by Peptiva, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Bromelain | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Pectinase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Protease 3 | 0 NP | -- |
| Diastase | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Artichoke extract and Ginger extract | 320 mg | -- |
| Vegetarian Digestive Enzyme Blend | 0 NP | -- |
| Protease | 0 NP | -- |
| Neutral Lipase, Bacterial | 0 NP | -- |
Other ingredients: Maltodextrin, Dicalcium Phosphate, Hypromellose, Microcrystalline Cellulose, Sodium Croscarmellose, Silica, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Adult Usage: Take one (1) capsule immediately before your heaviest meal.
Formula
Contains: Wheat, Soy & Milk (Lactose) (from enzyme blend fermentation medium).
Full spectrum enzyme blend
Precautions
Contains: Wheat, Soy & Milk (Lactose) (from enzyme blend fermentation medium).
Precautions: For adult use only.
Consult a healthcare practitioner before use if you have any medical condition, including bile obstruction or gallstones, or use any medications.
Keep out of the reach of children.
General Statements
Made in the UK
Did you know? Your body needs a full spectrum of enzymes to properly digest foods. Otherwise, you may experience occasional gas, bloating, and discomfort. Our advanced formula can help break down proteins, fats, fiber, carbohydrates and milk sugars.
Restore critical enzymes
Helps break down proteins, fats, fiber & carbohydrates Provides digestive relief
Storage
Keep product at room temperature and humidity [59-77(0)F (15-25(0)C), 60% RH].
General
R0
Formulation
Vegetarian digestive enzymes
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Prodigest is a registered trademark of Indena S.p.A., Italy.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Peptiva + Prodigest by Peptiva label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Peptiva + Prodigest by Peptiva
These are the 18 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Artichoke extract and Ginger extract
Interacts with363 drugs
Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...
Artichoke extract and Ginger extract monograph & interactionsVegetarian Digestive Enzyme Blend
- › Amylase
- › Bromelain
- › Lipase
- › Lactase
- › Cellulase
- › Invertase
- › Glucoamylase
- › Alpha-Galactosidase
- › Xylanase
- › Pectinase
- › Phytase
- › Hemicellulase
- › Protease 3
- › Diastase
- › Beta-Glucanase
- › Protease
- › Neutral Lipase, Bacterial
Other (inactive) ingredients: Maltodextrin, Dicalcium Phosphate, Hypromellose, Microcrystalline Cellulose, Sodium Croscarmellose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Peptiva + Prodigest by Peptiva Drug Interactions
Peptiva + Prodigest contains 18 ingredients, and 2 of them have known drug interactions. Altogether they interact with 488 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Peptiva + Prodigest?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Peptiva + Prodigest interact with 488 drugs. Click any drug to see the details.
2 of the 18 ingredients in Peptiva + Prodigest interact with drugs. Each result below shows which ingredient is responsible. Artichoke extract and Ginger extract Bromelain
Amlodipine BesilateIstin
How Amlodipine Besilate interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Extract And Ginger ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Extract And Ginger Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Extract And Ginger ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Extract And Ginger Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Extract And Ginger ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Extract And Ginger Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Extract And Ginger ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Extract And Ginger Extract + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Extract And Ginger ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Extract And Ginger Extract + Ammonium Chloride interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Extract And Ginger ExtractCytochrome P450 2b6 (cyp2b6) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
Read the full Artichoke Extract And Ginger Extract + Amobarbital, Secobarbital interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Extract And Ginger ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Extract And Ginger Extract + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Extract And Ginger ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Extract And Ginger Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Apixaban interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Extract And Ginger ExtractCytochrome P450 2b6 (cyp2b6) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
Read the full Artichoke Extract And Ginger Extract + Aprobarbital, Butabarbital, Phenobarbital interactionAprocitentanTryvio
How Aprocitentan interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Extract And Ginger ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Extract And Ginger Extract + Aprocitentan interactionArgatrobanArgatroban
How Argatroban interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Peptiva + Prodigest — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Extract And Ginger ExtractCytochrome P450 2b6 (cyp2b6) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
Read the full Artichoke Extract And Ginger Extract + Aspirin, Caffeine, Orphenadrine interactionBromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Peptiva + Prodigest — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Peptiva + Prodigest with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Artichoke extract and Ginger extract
Antidiabetes Drugs
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.
Antihypertensive Drugs
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.
Bromelain
Anticoagulant/Antiplatelet Drugs
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.
Tetracycline Antibiotics
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.
Brand information
Manufacturer and brand details for Peptiva + Prodigest, from the product label.
Peptiva
See all Peptiva products- Name
- Direct Digital, LLC
- City
- Charlotte
- State
- NC
- ZipCode
- 28202
- Phone Number
- 1-800-355-6050
- Web Address
- www.peptivaprobiotics.com
Peptiva + Prodigest by Peptiva: Common Questions
Does Peptiva + Prodigest by Peptiva interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Peptiva + Prodigest is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Peptiva + Prodigest’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Artichoke
Interacts with 363 drugsArtichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...
Read the full Artichoke monograph → Herb & supplement monographBromelain
Interacts with 141 drugsBromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...
Read the full Bromelain monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph →Sources & How We Checked
Peptiva + Prodigest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 47 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bromelain 19 references
- Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
- Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
- Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
- Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
- Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
- Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
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Lipase 1 reference
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Lactase 1 reference
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Phytase 7 references
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Proteolytic Enzymes (proteases) 3 references
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See these in context on the Proteolytic Enzymes (proteases) monograph →
Artichoke 16 references
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