Phosphatidyl Choline Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Phosphatidyl Choline against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Phosphatidyl Choline is a dietary supplement by Hardy Nutritionals with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, liver health, brain and memory support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Phosphatidyl Choline by Hardy Nutritionals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: phosphatidylcholine, a compound derived from soy lecithin. Phosphatidylcholine is a phospholipid — a type of fat molecule that plays a role in cell membranes and is involved in processes like brain function and liver health.
The softgel is made with gelatin, glycerin, and purified water.
Does it work?
Not established
Phosphatidylcholine is possibly effective for ulcerative colitis (a type of inflammatory bowel disease). For other conditions in this formula — nonalcoholic fatty liver disease, alcohol-related liver disease, Alzheimer disease, and anxiety — the evidence is insufficient to know whether it works.
That means either we don't have enough reliable research yet, or the research we do have is mixed.
How safe is it?
Well-documented data
Phosphatidylcholine is generally well tolerated when taken by mouth. The most common side effects reported in studies are altered taste, bloating, diarrhea, itching, nausea, sweating, and vomiting — especially at higher doses.
Ingesting very large amounts (30 grams per day) raises the risk of digestive upset and diarrhea. Choline (which phosphatidylcholine contains) is needed during pregnancy, but supplement safety beyond food sources hasn't been well studied.
If you're pregnant or breastfeeding, talk with your doctor before starting this product — there isn't enough data to know either way.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. Still, run your medications through our search tool on this page before you add this supplement.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
If you're dealing with ulcerative colitis, this may be worth discussing with your gastroenterologist. For other uses listed here, the evidence is too thin to know if it'll help you.
Since no interactions are documented, it's likely safe to combine with most medications — but check your specific drugs before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Phosphatidyl Choline, straight from the product label.
| Brand | Hardy Nutritionals |
|---|---|
| Barcode (UPC) | 799692010496 |
| Net contents | 90 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2025 |
| DSLD ID | 335632 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Phosphatidyl Choline by Hardy Nutritionals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Calories from Fat | 10 Calorie(s) | -- |
| Total Fat | 1 Gram(s) | 1% |
| Soy Lecithin | 1200 mg | -- |
| Phosphatidylcholine | 420 mg | -- |
Other ingredients: Gelatin, Glycerin, Water, Purified
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Phosphatidyl Choline may help to calm racing thoughts and promote mental clarity. Choline is an essential nutrient that supports optimal brain and cellular health.
Formulation
Choline is a natural ingredient of many foods, such as eggs, meats, whole grains, fruits, and vegetables. Supplementing your diet with choline helps ensure that your body will get enough for optimal health.
Made in U.S.A. May help calm racing thoughts and improve focus and attention
Technology-Enhanced Nutrition
Suggested/Recommended/Usage/Directions
Suggested Use: For adults, take one (1) softgel one to three times daily, preferably with a meal or as recommended by a physician.
Precautions
Caution: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Do not use if safety seal is damaged or missing.
Contains: Soy.
Storage
Store at room temperature.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
For more information and orders: Toll Free: 1-855-955-1114 www.GetHardy.com Send Comments to: PO Box 416 Sweetgrass, MT 59484
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Phosphatidyl Choline by Hardy Nutritionals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Phosphatidyl Choline by Hardy Nutritionals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.
Soy Lecithin
No knowninteractions
Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting...
Soy Lecithin monograph & interactionsOther (inactive) ingredients: Gelatin, Glycerin, Water, Purified. These complete the product’s ingredient list but are not active constituents.
Phosphatidyl Choline by Hardy Nutritionals Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Phosphatidyl Choline. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Phosphatidyl Choline, from the product label.
Hardy Nutritionals
See all Hardy Nutritionals products- Name
- NutraTek Health Innovations Inc.
- Street Address
- Box 919
- City
- Raymond
- State
- AB
- ZipCode
- T0K 2S0
- Phone Number
- 1-855-955-1114
- Web Address
- www.GetHardy.com
Phosphatidyl Choline by Hardy Nutritionals: Common Questions
Does Phosphatidyl Choline by Hardy Nutritionals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What exactly is phosphatidylcholine?
Will this help my ulcerative colitis?
Can I take this if I'm pregnant?
What side effects should I watch for?
Is this safe to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Phosphatidyl Choline is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Phosphatidyl Choline’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lecithin
Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting most of its health claims is limited, t...
Read the full Lecithin monograph → Herb & supplement monographPhosphatidylcholine
Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...
Read the full Phosphatidylcholine monograph →Sources & How We Checked
Phosphatidyl Choline's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 24 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lecithin 9 references
- Buchman AL, Dubin M, Jenden D, et al. Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients. Gastroenterology 1992;102:1363-70.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Chatellier G, Lacomblez L. Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Francais d'Etude de la Tetrahydroaminoacridine. BMJ 1990;300:495-9.
- Gelenberg AJ, Dorer DJ, Wojcik JD, et al. A crossover study of lecithin treatment of tardive dyskinesia. J Clin Psychiatry 1990;51:149-53.
- Little A, Levy R, Chuaqui-Kidd P, Hand D. A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1985;48:736-42. PubMed
- Palm M, Moneret-Vautrin DA, Kanny G, et al. Food allergy to egg and soy lecithins. Allergy 1999;54:1116-7. PubMed
- Drachman DA, Glosser G, Fleming P, et al. Memory decline in the aged: treatment with lecithin and physostigmine. Neurology 1982;32:944-50. PubMed
- Gelenberg, A. J., Doller-Wojcik, J. C., and Growdon, J. H. Choline and lecithin in the treatment of tardive dyskinesia: preliminary results from a pilot study. Am J Psychiatry 1979;136(6):772-776. PubMed
- Electronic Code of Federal Regulations. Title 21, Chapter 1, Subchapter B, Part 184: Direct food substances affirmed as Generally Recognized as Safe. Subpart B - listing of specific substances affirmed as GRAS. Sec. 184.1400 Lecithin. Available at: https:
Phosphatidylcholine 15 references
- Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
- Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
- Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
- Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
- Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
- Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
- Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
- Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
- Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
- Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
- Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
- Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
- Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
- Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
- Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC