Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Phosphatidyl Serine Plus DHA Ingredients & Drug Interactions

by Doctor's Best

Phosphatidyl Serine Plus DHA label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phosphatidyl Serine Plus DHA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phosphatidyl Serine Plus DHA is a dietary supplement by Doctor's Best with 2 active ingredients. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phosphatidyl Serine Plus DHA by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Phosphatidyl Serine Plus DHA by Doctor's Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phosphatidyl Serine Plus DHA by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: phosphatidylserine, a naturally occurring compound found in cell membranes, and docosahexaenoic acid (DHA), an omega-3 fatty acid. The inactive ingredients are soy lecithin, veggie softgel capsule material, and algae oil.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: memory and cognitive function support.
  • We looked for evidence on: Age-related cognitive decline, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia, mental clarity, concentration — and 1 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia.

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease. For other uses—including athletic performance, ADHD, general cognitive function, and dementia—the evidence we hold is insufficient to rate it.

We have no effectiveness data on file for DHA in this product.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, but long-term safety isn't fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea.

Insomnia is more likely at higher doses (600 mg), and gastrointestinal upset can occur at 200–300 mg per day. There isn't enough safety information to use this product during pregnancy or while breastfeeding.

Talk with your doctor or pharmacist about whether it's right for you in those situations.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use anticholinergic drugs (used for overactive bladder, certain poisonings, or neurological conditions) or cholinergic drugs (which increase acetylcholine activity). Both classes may have reduced effectiveness or additive effects with phosphatidylserine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with age-related cognitive decline or Alzheimer disease, though evidence is limited. If you take anticholinergic or cholinergic medications, check with your doctor or pharmacist before starting.

Pregnant or breastfeeding? You'll want to discuss it with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phosphatidyl Serine Plus DHA, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950004627
Net contents 60 Veggie Softgel(s)
Market status On market
Date entered into DSLD Jan 25, 2018
DSLD ID 82325
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phosphatidyl Serine Plus DHA by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Softgel(s)
Maximum serving Sizes:
1 Veggie Softgel(s)
Servings per container
60
UPC/BARCODE
753950004627
IngredientAmount% DV
Phosphatidylserine100 mg--
Docosahexaenoic Acid100 mg--

Other ingredients: Soy Lecithin, Veggie Softgel, Algae Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Doctor’s Best Phosphatidylserine plus DHA contains SerinAid Phosphatidylserine (PS) and vegan-sourced Docosahexaenoic Acid (DHA) to help support cognitive function.

Phosphatidyl Serine plus DHA with SerinAid PhosphatidylSerine

Contains soy

Formulation

Doctor’s Best Phosphatidylserine plus DHA contains SerinAid Phosphatidylserine (PS) and vegan-sourced Docosahexaenoic Acid (DHA) to help support cognitive function.

Veggie softgels, made with a healthy gelatin-free alternative to suit your lifestyle

Gluten free / Vegan

General Statements

Together PS and DHA help facilitate the electric signals that are the basis of neuron communication, supporting memory, mood, concentration, and stress control. Both PS and DHA are vital components of the membranes of nerve cells and the brain. They help promote executive memory, learning, and mental processing. Helps promote executive functions, including working and long term memory

Helps support memory and cognitive function

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

YDRB462

Brand IP Statement(s)

Science-Based Nutrition

SerinAid is a registered trademark of Chemi Nutra.

Seals/Symbols

Vegan

FDA Statement of Identity

Dietary Supplement

Precautions

Contains soy

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 softgel daily with food, or as recommended by a nutritionally-informed physician.

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phosphatidyl Serine Plus DHA by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phosphatidyl Serine Plus DHA label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phosphatidyl Serine Plus DHA by Doctor's Best

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veggie Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: SerinAid

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Docosahexaenoic Acid

100 mg per serving Form: Algae

Other (inactive) ingredients: Soy Lecithin, Veggie Softgel, Algae Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phosphatidyl Serine Plus DHA by Doctor's Best Drug Interactions

Want to check YOUR meds against Phosphatidyl Serine Plus DHA?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in Phosphatidyl Serine Plus DHA interact with 219 drugs. Click any drug to see the details.

1 of the 2 ingredients in Phosphatidyl Serine Plus DHA interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in Phosphatidyl Serine Plus DHA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phosphatidyl Serine Plus DHA, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
State
California
Phone Number
(800) 777-2474
Web Address
www.drbvitamins.com
Pharmacist Counseling Corner

Phosphatidyl Serine Plus DHA by Doctor's Best: Common Questions

Does Phosphatidyl Serine Plus DHA by Doctor's Best interact with any medications?
Yes. Based on its ingredients, Phosphatidyl Serine Plus DHA has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phosphatidyl Serine Plus DHA contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is phosphatidylserine, and what's it supposed to do?
Phosphatidylserine is a naturally occurring compound in cell membranes. It's possibly effective for age-related cognitive decline and Alzheimer disease, though evidence is limited. For other uses like ADHD or general brain function, the evidence isn't yet established.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety information for pregnancy or breastfeeding. The safety data advises against use in both situations. Talk with your doctor or pharmacist about your specific needs.
What side effects should I watch for?
The most common are flatulence, stomach upset, headache, insomnia, and nausea. Insomnia is more likely at higher doses (600 mg), and stomach upset can happen at 200–300 mg daily. If you notice any of these, let your doctor know.
Is long-term use safe?
Phosphatidylserine is generally well tolerated in studies, but long-term safety hasn't been fully established. If you're considering taking it for months or years, discuss it with your pharmacist or doctor.
What about the DHA in this product—does it interact with medications?
We don't hold interaction data for DHA (docosahexaenoic acid), so we can't check it. Use the medication search tool on this page to see if your medications interact with any ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phosphatidyl Serine Plus DHA is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phosphatidyl Serine Plus DHA label
Go deeper

The Full Monographs Behind Phosphatidyl Serine Plus DHA’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Phosphatidyl Serine Plus DHA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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