Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Phyto-Gen Cir-gen Ingredients & Drug Interactions

by Genestra Brands

Phyto-Gen Cir-gen label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phyto-Gen Cir-gen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phyto-Gen Cir-gen is a dietary supplement by Genestra Brands with 3 active ingredients. Its ingredients are commonly taken for chronic venous insufficiency, leg swelling and heaviness, varicose veins.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horse Chestnut (Aesculus hippocastanum) bud extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phyto-Gen Cir-gen by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with Phyto-Gen Cir-gen by Genestra Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phyto-Gen Cir-gen by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Phyto-Gen Cir-gen is a liquid supplement with 3 active ingredients: horse chestnut bud extract, Spanish chestnut bud extract, and servicetree bud extract. Horse chestnut is the one with the most research behind it; it's been studied for support of venous circulation.

The other two are botanical extracts included for similar circulation support. The liquid form includes water, ethanol (alcohol), and glycerin as inactive ingredients to preserve and deliver the plant extracts.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Circulatory support with horse chestnut.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Hemorrhoids, Postoperative swelling, Varicose veins, Leg swelling, Venous health.
  • The strongest evidence on file: Horse Chestnut is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Horse Chestnut is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids, Postoperative swelling.

Horse chestnut has possibly effective evidence for chronic venous insufficiency — the medical term for poor blood flow in the veins of the legs, which can cause swelling and heaviness. The evidence isn't strong enough to call it proven, but it's the best-supported use we have for this ingredient.

For hemorrhoids, irritable bowel syndrome, and kidney stones, the evidence is insufficient — meaning we don't have enough reliable data to say whether horse chestnut helps. We have no effectiveness data on file for the Spanish chestnut or servicetree extracts.

The evidence, ingredient by ingredient Horse Chestnut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Horse chestnut extract is generally well tolerated when properly processed — the toxic parts are removed before it reaches you. The most common side effects are dizziness, upset stomach, headache, and itching.

Calf muscle spasms have been reported in some people taking it for circulatory issues. The safety data advises against use during pregnancy and while breastfeeding.

There isn't enough information to know whether it's safe at those times. Raw or unprocessed horse chestnut parts are toxic and should never be used.

Side effects, ingredient by ingredient Horse Chestnut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Horse Chestnut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners and antiplatelet drugs (such as warfarin, apixaban, aspirin, clopidogrel, and similar medications) are the main medications to double-check before you take this product. Horse chestnut may increase bleeding risk when combined with them.

Run your exact medications through the interaction checker on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have chronic venous insufficiency and want to try a circulation-support supplement, horse chestnut is the ingredient here with the most research behind it. But if you take any blood thinners or antiplatelet medications — including aspirin, warfarin, or dabigatran — check with your doctor or pharmacist before starting this product, because the blood-thinning effects could add up.

The same goes for pregnancy and breastfeeding — talk it over with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phyto-Gen Cir-gen, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 883196120314
Net contents 0.5 Fluid Ounce(s); 15 mL
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 264423
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phyto-Gen Cir-gen by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.28 mL
Maximum serving Sizes:
0.28 mL
Servings per container
53
UPC/BARCODE
883196120314
IngredientAmount% DV
Horse Chestnut (Aesculus hippocastanum) bud extract0.09 mL--
Spanish Chestnut (Castanea sativa) bud extract0.09 mL--
Servicetree (Sorbus domestica) bud extract0.09 mL--

Other ingredients: Water, Purified, Ethanol, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Dose: Take 10 drops once daily or as recommended by your health professional. Invert bottle to 45 degrees and shake lightly allowing drops to fall directly into mouth or in 1/4 oz of water.

Precautions

For warnings and additional information, see outer box.

Use only if safety seal is intact.

Keep out of the reach of children.

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

This product was sealed for your protection. Do not use if box or contents are open or damaged.

Storage

Store in a cool, dry place.

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Scan to learn about our quality excellence V2 825-15U

FDA Statement of Identity

Dietary Supplement

Formula

Horse Chestnut Spanish Chestnut Servicetree

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phyto-Gen Cir-gen by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phyto-Gen Cir-gen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phyto-Gen Cir-gen by Genestra Brands

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.28 mL Dosage formLiquid Servings per container53 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Horse Chestnut (Aesculus hippocastanum) bud extract

Interacts with
122 drugs
0.09 mL per serving

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and h...

Horse Chestnut (Aesculus hippocastanum) bud extract monograph & interactions

Spanish Chestnut (Castanea sativa) bud extract

0.09 mL per serving

Servicetree (Sorbus domestica) bud extract

0.09 mL per serving

Other (inactive) ingredients: Water, Purified, Ethanol, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phyto-Gen Cir-gen by Genestra Brands Drug Interactions

Want to check YOUR meds against Phyto-Gen Cir-gen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Horse Chestnut (Aesculus hippocastanum) bud extract 122

Individual Drug Interactions

The ingredients in Phyto-Gen Cir-gen interact with 122 drugs. Click any drug to see the details.

1 of the 3 ingredients in Phyto-Gen Cir-gen interact with drugs. Each result below shows which ingredient is responsible. Horse Chestnut (Aesculus hippocastanum) bud extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Phyto-Gen Cir-gen with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Horse Chestnut (Aesculus hippocastanum) bud extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.

Likelihood Possible Evidence D
Horse Chestnut (Aesculus hippocastanum) bud extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phyto-Gen Cir-gen, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

Phyto-Gen Cir-gen by Genestra Brands: Common Questions

Does Phyto-Gen Cir-gen by Genestra Brands interact with any medications?
Yes. Based on its ingredients, Phyto-Gen Cir-gen has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phyto-Gen Cir-gen contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin or a prescription blood thinner?
Not without checking first. Horse chestnut has mild blood-thinning properties and may increase your bleeding risk if you're already on these drugs. Talk with your doctor or pharmacist — they can tell you whether it's safe for your specific situation or whether you should skip it.
Is this safe during pregnancy or while breastfeeding?
The safety data advises against it. There isn't enough information to know whether it's safe for your baby during pregnancy or breastfeeding. Talk with your doctor or pharmacist to decide what's best for you.
What does horse chestnut actually do?
It's been studied most for chronic venous insufficiency — poor circulation in the leg veins that causes swelling and heaviness. The evidence says it's possibly effective for that, meaning it may help but isn't proven. For other uses like hemorrhoids or IBS, we don't have enough reliable data.
What are the most common side effects?
When the extract is properly processed, dizziness, upset stomach, headache, and itching are the most common. Some people have also reported calf muscle spasms. Most people tolerate it well, but side effects can happen.
Does this liquid contain alcohol?
Yes — ethanol is listed as an inactive ingredient to preserve the plant extracts. If you need to avoid alcohol, this product isn't for you.
Can I use raw horse chestnut instead of this processed extract?
No. Raw or unprocessed horse chestnut is toxic. This supplement is made from properly processed seed extract with the toxic parts removed — that's the only safe form to use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phyto-Gen Cir-gen label
Go deeper

The Full Monographs Behind Phyto-Gen Cir-gen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horse Chestnut

Interacts with 122 drugs

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...

Read the full Horse Chestnut monograph →
Sources

Sources & How We Checked

Phyto-Gen Cir-gen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horse Chestnut 21 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Greeske K, Pohlmann BK. Horse chestnut seed extract-an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency. Fortschr Med 1996;114:196-200.
  6. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  7. Takegoshi K, Tohyama T, Okuda K, et al. A case of Venoplant-induced hepatic injury. Gastroenterol Jpn 1986;21:62-5.
  8. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
  9. Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children. Allergy 1992;47:380-3.
  10. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  11. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103:507-13. PubMed
  12. Comaish JS, Kersey PJ. Contact dermatitis to extract of horse chestnut (esculin). Contact Dermatitis 1980;6:150-1. PubMed
  13. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd. PubMed
  14. Ottillinger, B. and Greeske, K. Rational therapy of chronic venous insufficiency--chances and limits of the therapeutic use of horse-chestnut seeds extract. BMC.Cardiovasc.Disord. 2001;1(1):5. PubMed
  15. Pittler, M. H. and Ernst, E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane.Database.Syst.Rev. 2004;(2):CD003230. PubMed
  16. Fang, Y., Zhao, L., Yan, F., Xia, X., Xu, D., and Cui, X. Escin improves sperm quality in male patients with varicocele-associated infertility. Phytomedicine. 2010;17(3-4):192-196. PubMed
  17. De Smet, P. A., Van den Eertwegh, A. J., Lesterhuis, W., and Stricker, B. H. Hepatotoxicity associated with herbal tablets. BMJ 7-13-1996;313(7049):92.
  18. Rehn, D., Unkauf, M., Klein, P., Jost, V., and Lucker, P. W. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Arzneimittelforschung 1996;46(5):483-487.
  19. Edem E, Kahyaoglu B, Çakar MA. Acute Effusive Pericarditis due to Horse Chestnut Consumption. Am J Case Rep. 2016;17:305-8. PubMed
  20. Costa Santos D, Lérias G, Madruga I. Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement. Eur J Case Rep Intern Med 2021;8(3):002389. PubMed
  21. Yi HY, Lee JY. Poisoning due to consumption of horse chestnut seed. Clin Exp Emerg Med 2021;8(4):333-335. PubMed

See these in context on the Horse Chestnut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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