Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

PhytoArtemisinin Ingredients & Drug Interactions

by Allergy Research Group

PhytoArtemisinin label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PhytoArtemisinin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PhytoArtemisinin is a dietary supplement by Allergy Research Group with 2 active ingredients. Its ingredients are commonly taken for malaria (traditional), fever, inflammation.Based on those ingredients, 889 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artemisinin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PhytoArtemisinin by Allergy Research Group

Ask about any prescription or over-the-counter medication and we check it for interactions with PhytoArtemisinin by Allergy Research Group — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of PhytoArtemisinin by Allergy Research Group

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

PhytoArtemisinin has two active ingredients: artemisinin (the key compound from Sweet Annie) and Gleditsia (spine) extract. Artemisinin is used in herbal medicine primarily for allergic rhinitis (hay fever), though it's also studied for malaria, joint inflammation, and liver disease.

The product also contains two inactive ingredients — Hydroxypropyl Methylcellulose and L-Leucine — which are a capsule binder and flow agent, respectively.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Sweet Annie's overall clinical evidence instead.

Moderate

Some clinical evidence supports Sweet Annie for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Natural Medicines).

Artemisinin is rated possibly effective for allergic rhinitis (hay fever). For other uses listed — nonalcoholic fatty liver disease, malaria, and osteoarthritis — the evidence we hold is insufficient to rate whether it works.

We have no effectiveness data on file for Gleditsia (spine) extract.

The evidence, ingredient by ingredient Sweet Annie

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Artemisinin is generally well tolerated when taken by mouth. The most common side effects are nausea and vomiting.

Rarely, it can cause hepatotoxicity (liver damage) — one case was documented in which a patient developed hepatitis after taking artemisinin 200 mg three times daily for 10 days, with elevated liver enzymes and dark urine that resolved within two weeks of stopping. One mild allergic reaction to Sweet Annie tea has been reported (rash and cough).

Taken sublingually at low doses, it may cause tongue numbness or throat itching in people sensitive to it. Avoid PhytoArtemisinin during pregnancy because of possible harm to the developing baby.

Do not use while breastfeeding — there is not enough safety information. Quality and dose vary widely across products, and this supplement should not replace proven treatments.

Side effects, ingredient by ingredient Sweet Annie

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sweet Annie.
  • The most serious interaction on file is rated Moderate.
  • For scale: 890 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking PhytoArtemisinin, double-check with your pharmacist if you take any drugs that stress the liver (hepatotoxic drugs), medications broken down by CYP3A4 (including many statins, blood pressure drugs, and immunosuppressants), or medications metabolized by CYP2B6. Severity is Moderate for all three categories.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

PhytoArtemisinin may be worth considering if you're interested in herbal support for hay fever, but it carries interaction risks with drugs that stress the liver and several medication classes your body breaks down in the liver. Check your exact medications before starting, especially if you take anything for the liver, heart, or hormones.

Talk to your pharmacist — they can help you decide if it fits your regimen.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PhytoArtemisinin, straight from the product label.

Brand Allergy Research Group
Barcode (UPC) 713947749900
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 233528
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PhytoArtemisinin by Allergy Research Group, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
713947749900
IngredientAmount% DV
Artemisinin200 mg--
Gleditsia (spine) extract700 mg--

Other ingredients: Hydroxypropyl Methylcellulose, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

PhytoArtemisinin contains pure artemisinin (Qinghaosu), the active constituent of the herb Artemisia annua (sweet wormwood), combined with phytosaponins.

Artemisinin with phytosaponins

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 1 or 2 capsules two or three times daily before meals, or as directed by a healthcare practitioner. Artemisinin is best taken as part of a program that includes appropriate liver support nutrients.

Precautions

Sensitive individuals may want to take with food.

Caution: Not indicated for pregnant or nursing women.

This product should only be used under under the guidance of a qualified healthcare practitioner with ongoing monitoring of liver enzymes and hemoglobin during its use. In rare cases may cause idiosyncratic liver dysfunction. Combining with antioxidants or iron may theoretically decrease effectiveness.

Warning: Consuming this product can expose you to lead which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food

FDA Statement of Identity

Dietary Supplement

Formulation

Hypoallergenic

Variation in product color may occur.

Storage

Keep in a cool, dry place, tightly capped.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PhytoArtemisinin by Allergy Research Group label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PhytoArtemisinin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PhytoArtemisinin by Allergy Research Group

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Artemisinin

Interacts with
889 drugs
200 mg per serving

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studie...

Artemisinin monograph & interactions

Gleditsia (spine) extract

700 mg per serving Form: Saponins

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

PhytoArtemisinin by Allergy Research Group Drug Interactions

Want to check YOUR meds against PhytoArtemisinin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
889Drugs
889 Moderate

Ingredients driving the most interactions

Artemisinin 889

Individual Drug Interactions

The ingredients in PhytoArtemisinin interact with 889 drugs. Click any drug to see the details.

1 of the 2 ingredients in PhytoArtemisinin interact with drugs. Each result below shows which ingredient is responsible. Artemisinin

Each ingredient & the kinds of drugs it affects

For each ingredient in PhytoArtemisinin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Artemisinin3 drug types · 889 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP2B6, possibly increasing CYP2B6 activity by 1.6-fold. However, Sweet Annie extract seems to inhibit the activity of CYP2B6 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP2B6 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP3A4, possibly increasing CYP3A4 activity by 1.9-fold. However, Sweet Annie extract seems to inhibit the activity of CYP3A4 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP3A4 substrates.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use might have additive adverse hepatotoxic effects.
There is some concern that Sweet Annie can adversely affect the liver.

Likelihood Possible Evidence D
Artemisinin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PhytoArtemisinin, from the product label.

Allergy Research Group

See all Allergy Research Group products
Name
Allergy Research Group
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800-545-9960
Web Address
www.allergyresearch.com
Pharmacist Counseling Corner

PhytoArtemisinin by Allergy Research Group: Common Questions

Does PhytoArtemisinin by Allergy Research Group interact with any medications?
Yes. Based on its ingredients, PhytoArtemisinin has a known interaction with 889 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PhytoArtemisinin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
No — the safety data advises against artemisinin during pregnancy because of possible harm to your developing baby. Talk to your doctor or midwife before taking any supplement while pregnant.
Is it safe while breastfeeding?
No — there isn't enough safety information to know if artemisinin passes into breast milk or how it might affect a nursing infant. Avoid it while breastfeeding, and discuss alternatives with your pharmacist or doctor.
Does this really work for allergies?
Artemisinin is rated possibly effective for allergic rhinitis (hay fever), which means there is some evidence but it's not conclusive. Whether it'll help you depends on your individual situation — your pharmacist can discuss what the research shows and how it compares to standard allergy treatments.
What are the most common side effects?
Nausea and vomiting are the most common side effects when taken by mouth. Rarely, artemisinin can cause liver damage, so if you develop abdominal pain, dark urine, or yellowing of the skin or eyes, stop taking it and see your doctor right away.
How long can I safely take this?
Artemisinin is generally used short-term, but quality and dose vary widely across products. It should not replace proven treatments. Talk to your pharmacist about how long is appropriate for your situation and what product quality to look for.
What is Gleditsia extract in here?
Gleditsia (spine) extract is the second active ingredient, but we have no effectiveness or interaction data on file for it. Ask your pharmacist or the manufacturer what role it plays in this formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PhytoArtemisinin label
Go deeper

The Full Monographs Behind PhytoArtemisinin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sweet Annie

Interacts with 889 drugs

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studied for malaria, the herb itself as a supp...

Read the full Sweet Annie monograph →
Sources

Sources & How We Checked

PhytoArtemisinin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sweet Annie 11 references
  1. Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000;73:487-93. PubMed
  2. Rath K, Taxis K, Walz G, et al. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004;70:128-32. DOI
  3. Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin-Washington, 2008. MMWR Morb Mortal Wkly Rep 2009;58:854-8.
  4. Xing J, Kirby BJ, Whittington D, et al. Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Drug Metabl Dispos 2012;40(9):1757-64. PubMed
  5. Savage RL, Hill GR, Barnes J, Kenyon SH, Tatley MV. Suspected hepatotoxicity with a supercritical carbon dioxide extract of Artemisia annua in grapeseed oil used in New Zealand. Front Pharmacol. 2019;10:1448. PubMed
  6. Ruperti-Repilado FJ, Haefliger S, Rehm S, et al. Danger of herbal tea: a case of acute cholestatic hepatitis due to Artemisia annua tea. Front Med (Lausanne). 2019;6:221. PubMed
  7. Yang J, Shen Z, Liu L, et al. Clinical efficacy and safety of Artesimia annua-Sublingual immunotherapy in seasonal allergic rhinitis patients based on different intervention time. Int Arch Allergy Immunol 2022;183(8):852-859.
  8. Kane NF, Kiani BH, Desrosiers MR, Towler MJ, Weathers PJ. Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro. J Ethnopharmacol 2022. DOI
  9. Feng Y, Cao Y, Liu Y, et al. Clinical efficacy and safety of coseasonal initiation of Artemisia annua sublingual immunotherapy on patients with Artemisia-induced rhinoconjunctivitis. Am J Otolaryngol 2023;44(5):103942. PubMed
  10. Yang J, Wang W, Shen Z, et al. Efficacy and safety of Artemisia annua sublingual immunotherapy in patients with seasonal allergic rhinoconjunctivitis over two pollen seasons. Eur Arch Otorhinolaryngol. 2023;280(11):4939-4947. PubMed
  11. Shen Z, Zhang P, Kang W, et al. Clinical efficacy in one-year treatment with Artemisia annua-SLIT drops in monosensitized and polysensitized individuals. Am J Otolaryngol 2023;44(6):104002. PubMed

See these in context on the Sweet Annie monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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