Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

PM Reset Formula Ingredients & Drug Interactions

by Herbalife

PM Reset Formula label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PM Reset Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

PM Reset Formula is a dietary supplement by Herbalife with 6 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 1,144 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Peppermint, Powder, Aloe Vera Gel, Dandelion Root Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against PM Reset Formula by Herbalife

Ask about any prescription or over-the-counter medication and we check it for interactions with PM Reset Formula by Herbalife — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of PM Reset Formula by Herbalife

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Exclusive Blend” is a proprietary blend — the label gives one combined amount (228 mg) without saying how much of each component you get.

PM Reset Formula contains six active ingredients. Bromelain is an enzyme from pineapple; L-taurine is an amino acid; peppermint powder is from the peppermint plant; lemon bioflavonoid complex comes from lemon; dandelion root extract is from the dandelion plant; and aloe vera gel is from the inner leaf of the aloe plant.

The product also contains inactive ingredients—maltodextrin, microcrystalline cellulose, calcium carbonate, croscarmellose sodium, silicon dioxide, magnesium stearate, hydroxypropyl methylcellulose, and glycerin—which are fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive health and fluid balance.
  • We looked for evidence on: Abdominal pain, Constipation, Dyspepsia, Flatulence, Gastroesophageal reflux disease (GERD), Irritable bowel syndrome (IBS) — and 3 related terms.
  • The strongest evidence on file: Peppermint is rated "Likely Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Aloe is rated "Possibly Effective" for Constipation.
  • Also on file: Peppermint is rated "Possibly Effective" for Dyspepsia.

The evidence supporting PM Reset Formula's ingredients is mixed and often limited. Peppermint is rated Likely Effective for irritable bowel syndrome (IBS) and Possibly Effective for indigestion and chemotherapy-related nausea.

Aloe is Possibly Effective for acne, skin conditions like psoriasis, burns, constipation, and diabetes. L-taurine is Possibly Effective for hepatitis and congestive heart failure (CHF), though rated Possibly Ineffective for obesity.

Bromelain, lemon bioflavonoid complex, and dandelion root all have Insufficient Reliable Evidence for their listed conditions, meaning the data we hold does not establish they work for those uses.

The evidence, ingredient by ingredient Bromelain Taurine Peppermint Lemon Dandelion Aloe

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated at typical doses in the short term, though long-term safety data is limited for several. Common side effects include gastrointestinal upset—diarrhea, stomach discomfort, heartburn, and nausea—from bromelain, L-taurine, peppermint, lemon, and dandelion.

Aloe latex (which may be in this product depending on the source) can cause abdominal pain and cramping; long-term overuse risks serious potassium loss and heart rhythm problems. Rare allergic reactions, including anaphylaxis, have been reported with bromelain, peppermint, dandelion, and aloe.

For pregnancy, the data advises against aloe (possibly unsafe due to uterine stimulation and strong laxative effects) and against bromelain (not enough safety data). L-taurine and peppermint are rated Likely Safe in pregnancy.

For lemon and dandelion, there is not enough data to know either way—talk with your doctor or pharmacist for personalized advice. For breastfeeding, avoid aloe and bromelain; L-taurine and peppermint are Likely Safe.

Data on lemon and dandelion while breastfeeding is not on file, so discuss with your provider.

Side effects, ingredient by ingredient Bromelain Taurine Peppermint Lemon Dandelion Aloe

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Lemon, Aloe, Peppermint, Dandelion, Bromelain, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,145 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking PM Reset Formula, check with your pharmacist if you take any of these: heart medications like digoxin (Major risk), blood thinners or antiplatelet drugs like warfarin or aspirin (Moderate), blood-pressure medications (Moderate), diabetes drugs (Moderate), lithium (Moderate), diuretics or water pills (Moderate), fluoroquinolone antibiotics like ciprofloxacin (Moderate), or medications metabolized by liver enzymes including cyclosporine, certain antidepressants, and many others (Moderate). These are the medication types with documented interactions; your specific drug may or may not be affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

PM Reset Formula is a multi-ingredient product with interactions spanning more than 1,000 medications. Anyone taking blood thinners, heart medications (especially digoxin), blood-pressure drugs, diabetes medications, lithium, or immunosuppressants should check with their pharmacist before use.

If you're pregnant or breastfeeding, discuss this product with your doctor or pharmacist first—some ingredients carry safety concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PM Reset Formula, straight from the product label.

Brand Herbalife
Barcode (UPC) 1154US
Net contents 42 PM Tablet(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 335014
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PM Reset Formula by Herbalife, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
21
UPC/BARCODE
1154US
IngredientAmount% DV
Bromelain0 NP--
L-Taurine0 NP--
Peppermint, Powder0 NP--
Lemon Bioflavonoid Complex0 NP--
Dandelion Root Extract, Powder0 NP--
Aloe Vera Gel0 NP--
Exclusive Blend228 mg--

Other ingredients: Maltodextrin, Microcrystalline Cellulose, Calcium Carbonate, Croscarmellose Sodium, Silicon Dioxide, Magnesium Stearate, Hydroxypropyl Methylcellulose, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Made in USA with US and imported ingredients

Begin and maintain your digestive health regimen with this 21-Day Herbal Balancing Program.

Brand IP Statement(s)

Copyright 2023 Herbalife Nutrition

Formula

PM Reset Formula is formulated with dandelion, traditionally used for healthy fluid balance.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended use: Take 2 AM tablets in the morning and 2 PM tablets in the evening for 21 days.

General Statements

Herbalife Nutrition also recommends these digestive health line products: Herbal Aloe soothes the stomach, relieves occasional indigestion, and supports nutrient absorption and intestinal health. Active Fiber Complex is specially formulated with 6 g of dietary fiber to promote regularity and support the growth of beneficial intestinal bacteria. Simply Probiotic contains 1 billion cultures, tough enough to survive and reach the intestines, right where it needs to be for daily digestive balance. 30-day money-back guarantee. This exclusively formulated product is only available through Herbalife Nutrition independent distributors.

Precautions

Notice: This product is not recommended for children, pregnant or lactating women.

Notice: This product is not recommended for children, pregnant or lactating women.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PM Reset Formula by Herbalife label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PM Reset Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PM Reset Formula by Herbalife

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container21 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Maltodextrin, Microcrystalline Cellulose, Calcium Carbonate, Croscarmellose Sodium, Silicon Dioxide, Magnesium Stearate, Hydroxypropyl Methylcellulose, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

PM Reset Formula by Herbalife Drug Interactions

Want to check YOUR meds against PM Reset Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,144Drugs
1 Major 1,128 Moderate 15 Minor

Ingredients driving the most interactions

Peppermint, Powder 796
Aloe Vera Gel 461
Dandelion Root Extract, Powder 457
L-Taurine 173
Bromelain 141

Individual Drug Interactions

The ingredients in PM Reset Formula interact with 1,144 drugs. Click any drug to see the details.

6 of the 6 ingredients in PM Reset Formula interact with drugs. Each result below shows which ingredient is responsible. Peppermint, Powder Aloe Vera Gel Dandelion Root Extract, Powder L-Taurine Bromelain Lemon Bioflavonoid Complex

Each ingredient & the kinds of drugs it affects

For each ingredient in PM Reset Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Peppermint, Powder5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint, Powder full monograph & interactions

Aloe Vera Gel7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe Vera Gel full monograph & interactions

Dandelion Root Extract, Powder7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Dandelion Root Extract, Powder full monograph & interactions

L-Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
L-Taurine full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Lemon Bioflavonoid Complex1 drug type · 1 drug

Itraconazole (Sporanox)

Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.

Likelihood Possible Evidence D
Lemon Bioflavonoid Complex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PM Reset Formula, from the product label.

Herbalife

Name
Herbalife International of America, Inc.
Street Address
800 W. Olympic Blvd., Suite 406
City
Los Angeles
State
CA
ZipCode
90015
Pharmacist Counseling Corner

PM Reset Formula by Herbalife: Common Questions

Does PM Reset Formula by Herbalife interact with any medications?
Yes. Based on its ingredients, PM Reset Formula has a known interaction with 1,144 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PM Reset Formula contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is peppermint in this product safe if I take other medications?
Peppermint can theoretically raise levels of several medications your liver processes, including some blood-pressure and heart drugs, and the immunosuppressant cyclosporine. No human cases have been reported yet, but check your exact medications with the search tool on this page to be sure.
Can I take this if I'm on blood thinners?
No, not without checking with your pharmacist first. Bromelain, dandelion root, and aloe vera gel all have documented interactions with blood thinners and may increase bleeding risk. This product is not a safe match for warfarin, aspirin, or similar drugs.
What does bromelain do in this formula?
Bromelain is an enzyme from pineapple. The evidence for its effectiveness in PM Reset Formula's listed conditions—hay fever, burns, cancer, nerve pain, vein problems, and diabetes—is insufficient, meaning we don't have reliable data showing it works for those uses.
Is aloe vera gel safe to take by mouth?
Aloe gel is generally well tolerated, but aloe latex (the yellow substance under the leaf skin) can cause serious side effects with long-term or high-dose use, including potassium loss and heart rhythm problems. This product contains aloe vera gel, but the exact form and amount matter—ask your pharmacist if you have concerns.
Can I take this if I'm pregnant?
Not safely without talking to your doctor first. Aloe is rated possibly unsafe because it may stimulate the uterus and act as a strong laxative. Bromelain has not been studied enough in pregnancy. L-taurine and peppermint are considered likely safe, but a full review with your provider is best.
What are the most common side effects?
Gastrointestinal upset is most common: diarrhea, stomach discomfort, heartburn, nausea, and gas. These can come from any of the plant ingredients—bromelain, peppermint, dandelion, or aloe. Rare allergic reactions including anaphylaxis have been reported with several ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PM Reset Formula is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PM Reset Formula label
Go deeper

The Full Monographs Behind PM Reset Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph → Herb & supplement monograph

Lemon

Interacts with 1 drug

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it can support hydration and a healthy diet...

Read the full Lemon monograph → Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph → Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph →
Sources

Sources & How We Checked

PM Reset Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 151 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
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Taurine 21 references
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Peppermint 41 references
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Lemon 2 references
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Dandelion 27 references
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Aloe 41 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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