Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Poly-Zyme 022 Ingredients & Drug Interactions

by LifeLink

Poly-Zyme 022 label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Poly-Zyme 022 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Poly-Zyme 022 is a dietary supplement by LifeLink with 3 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Poly-Zyme 022 by LifeLink

Ask about any prescription or over-the-counter medication and we check it for interactions with Poly-Zyme 022 by LifeLink — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Poly-Zyme 022 by LifeLink

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Poly-Zyme 022 contains 3 active ingredients: papain, pancreatin, and thymus concentrate. Papain is an enzyme from papaya that's intended to aid digestion.

Pancreatin is an enzyme blend from the pancreas meant to support nutrient breakdown. Thymus concentrate comes from thymus tissue and is included for immune support.

The tablet also contains lactose and magnesium stearate as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Papain's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: prevent metastases and treat herpes infections.
  • We looked for evidence on: Cancer, Herpes zoster (shingles), Viral infection, Tumor progression.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Cancer (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Herpes zoster (shingles).

Our data shows insufficient evidence to rate papain for cancer, dental caries, radiation dermatitis, exercise-induced muscle soreness, shingles, or intestinal parasite infection. We hold no effectiveness ratings for pancreatin or thymus concentrate in this product.

The evidence, ingredient by ingredient Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally well tolerated as a food, but the supplement form may irritate your digestive tract or trigger allergic reactions in sensitive people — itchy watery eyes, runny nose, sneezing, abdominal cramps, sweating, and diarrhea are possible. High oral doses may be unsafe and in rare cases can cause serious problems like esophageal perforation or severe inflammation of the stomach lining.

Papain during pregnancy raises safety concerns, so it's best avoided. There isn't enough reliable safety data for papain while breastfeeding — talk with your doctor or pharmacist about whether it's right for you.

Side effects, ingredient by ingredient Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any blood thinner, double-check with your doctor or pharmacist before taking this product — papain may increase its effect. We could not check pancreatin or thymus concentrate for interactions, so run them through the medication search tool on this page with your other drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Poly-Zyme 022 is marketed for digestive enzyme support, but the evidence for papain's effectiveness on its listed uses is not yet established. If you take warfarin or any blood thinner, check with your doctor or pharmacist before starting — papain may increase its effect.

Papain may cause digestive upset or allergic reactions in some people, and pregnant individuals should avoid it. Always confirm your specific medications with this product first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Poly-Zyme 022, straight from the product label.

Brand LifeLink
Barcode (UPC) 639793402045
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Oct 1, 2012
DSLD ID 11824
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Poly-Zyme 022 by LifeLink, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Tablet(s)
Maximum serving Sizes:
20 Tablet(s)
UPC/BARCODE
639793402045
IngredientAmount% DV
Papain15 mg--
Pancreatin12 mg--
Thymus Concentrate6 mg--

Other ingredients: Lactose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

An enteric-coated proteolytic enzyme formula 022

Poly-Zyme 022 is used by cancer patients to prevent metastases, and as an antiviral by people with herpes infections, such as shingles. The tablets are enteric coated to protect the enzymes while they pass through the stomach.

Suggested/Recommended/Usage/Directions

Suggested Use: 6 to 20 tablets daily in divided doses or as directed by a health care professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Poly-Zyme 022 by LifeLink label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Poly-Zyme 022 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Poly-Zyme 022 by LifeLink

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
15 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Pancreatin

12 mg per serving

Thymus Concentrate

6 mg per serving

Other (inactive) ingredients: Lactose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Poly-Zyme 022 by LifeLink Drug Interactions

Want to check YOUR meds against Poly-Zyme 022?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Papain 2

Individual Drug Interactions

The ingredients in Poly-Zyme 022 interact with 2 drugs. Click any drug to see the details.

1 of the 3 ingredients in Poly-Zyme 022 interact with drugs. Each result below shows which ingredient is responsible. Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Poly-Zyme 022 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Poly-Zyme 022, from the product label.

LifeLink

See all LifeLink products
Name
LifeLink
City
Grover Beach
State
CA
ZipCode
93433
Web Address
http://www.lifelinknet.com
Pharmacist Counseling Corner

Poly-Zyme 022 by LifeLink: Common Questions

Does Poly-Zyme 022 by LifeLink interact with any medications?
Yes. Based on its ingredients, Poly-Zyme 022 has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Poly-Zyme 022 contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Concentrated papain and unripe papaya products are best avoided in pregnancy due to safety concerns. Talk with your doctor or pharmacist before taking this product — they can give you personalized advice based on your situation.
Can I take this while breastfeeding?
There isn't enough reliable safety information on papain during breastfeeding. Discuss it with your doctor or pharmacist to decide what's best for you and your baby.
What side effects might I notice?
Most people tolerate papain well at normal doses. Some sensitive people may have allergic reactions — itchy watery eyes, runny nose, sneezing, abdominal cramps, sweating, or diarrhea. High doses may cause digestive upset. Stop and talk with your pharmacist if you notice any of these.
Does this product actually work for the conditions listed?
Our data shows insufficient evidence to rate papain for cancer, dental caries, radiation dermatitis, exercise-induced muscle soreness, shingles, or intestinal parasite infection. We hold no effectiveness information for the pancreatin or thymus concentrate in this product either.
Why does the interaction data say 'none held' for two ingredients?
We could not check pancreatin or thymus concentrate because we don't hold monographs for them. That doesn't mean they're safe with all medications — use the search tool on this page to verify your specific drugs, or ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Poly-Zyme 022 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Poly-Zyme 022 label
Go deeper

The Full Monographs Behind Poly-Zyme 022’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Poly-Zyme 022's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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