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Dietary supplement

Polypodium Leucotomos Extract 1000 mg Ingredients & Drug Interactions

by SuperSmart

Polypodium Leucotomos Extract 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Polypodium Leucotomos Extract 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Polypodium Leucotomos Extract 1000 mg is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for sun sensitivity and sunburn protection, skin conditions like vitiligo and melasma, polymorphic light eruption.Based on those ingredients, 643 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Polypodium leucotomos leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Polypodium Leucotomos Extract 1000 mg by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with Polypodium Leucotomos Extract 1000 mg by SuperSmart — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Polypodium Leucotomos Extract 1000 mg by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Polypodium leucotomos leaf extract at 1,000 mg per capsule. Polypodium leucotomos is a tropical fern traditionally used in herbal medicine.

The capsule also contains two inactive ingredients — acacia gum and white rice flour — which serve as binders and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Polypodium Leucotomos's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Skin anti-aging and photoprotection.
  • We looked for evidence on: Actinic keratoses, Atopic dermatitis (eczema), Cutaneous lupus erythematosus (CLE), Melasma, Polymorphous light eruption (PMLE), Psoralen-UVA (PUVA) photodamage — and 4 related terms.
  • The closest evidence on file: Polypodium Leucotomos is rated "Insufficient Reliable Evidence To Rate" for Atopic dermatitis (eczema) (Natural Medicines).
  • Also on file: Polypodium Leucotomos is rated "Insufficient Reliable Evidence To Rate" for Melasma, Sunburn, Vitiligo, Actinic keratoses, and more.

The evidence for Polypodium leucotomos is not yet established in the data we hold. Proposed uses include dementia, atopic dermatitis (eczema), actinic keratoses (rough sun-damaged spots on skin), and cutaneous lupus erythematosus (a skin form of lupus).

All of these carry a rating of insufficient reliable evidence, meaning the studies so far haven't been robust enough to confirm whether it works for any of them.

The evidence, ingredient by ingredient Polypodium Leucotomos

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Polypodium leucotomos is generally well tolerated in studies, though long-term safety data is limited. The only adverse effect noted in the literature is itching (pruritus), which has occurred rarely in people taking it by mouth.

It should be avoided during pregnancy and while breastfeeding, as safety data in these populations is not established.

Side effects, ingredient by ingredient Polypodium Leucotomos

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Polypodium Leucotomos.
  • The most serious interaction on file is rated Minor.
  • For scale: 644 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this if you're on any medications broken down by the CYP3A4 enzyme pathway — a liver processing system that handles over 600 drugs, including statins, blood pressure medications, immunosuppressants, and many others. Polypodium leucotomos may slow this pathway and raise drug levels in your blood.

Use the medication checker on this page to look up your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Polypodium leucotomos may be worth considering if you're interested in its traditional uses, but effectiveness evidence is thin. The bigger practical concern is that it can slow the breakdown of hundreds of medications, potentially raising their levels.

Before you take it, check your exact prescriptions with your doctor or pharmacist — especially if you take statins, blood pressure drugs, or any immunosuppressants.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Polypodium Leucotomos Extract 1000 mg, straight from the product label.

Brand SuperSmart
Barcode (UPC) 5453003825494
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 285338
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Polypodium Leucotomos Extract 1000 mg by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
5453003825494
IngredientAmount% DV
Polypodium leucotomos leaf extract1000 mg--

Other ingredients: Acacia Gum, White Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Skin anti-aging

FDA Statement of Identity

Dietary Supplement

Formula

Polypodium leucotomos extract 1000 mg per day

Each vegetarian capsule contains 500 mg of Polypodium leucotomos leaf extract.

Suggested/Recommended/Usage/Directions

Directions: Adults. Take one to two capsules daily in the morning 30 minutes prior sun exposure.

Precautions

Precautions: You should still use topical suncreams when exposed to the sun. Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.

Keep out of childrens' reach.

As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.

Storage

Store away from direct light, heat and humidity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Polypodium Leucotomos Extract 1000 mg by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Polypodium Leucotomos Extract 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Polypodium Leucotomos Extract 1000 mg by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Polypodium leucotomos leaf extract

Interacts with
643 drugs
1000 mg per serving

Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain light-trigger...

Polypodium leucotomos leaf extract monograph & interactions

Other (inactive) ingredients: Acacia Gum, White Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Polypodium Leucotomos Extract 1000 mg by SuperSmart Drug Interactions

Want to check YOUR meds against Polypodium Leucotomos Extract 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
643Drugs
643 Minor

Ingredients driving the most interactions

Polypodium leucotomos leaf extract 643

Individual Drug Interactions

The ingredients in Polypodium Leucotomos Extract 1000 mg interact with 643 drugs. Click any drug to see the details.

1 of the 1 ingredient in Polypodium Leucotomos Extract 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Polypodium leucotomos leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Polypodium Leucotomos Extract 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Polypodium leucotomos leaf extract1 drug type · 643 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggests that Polypodium leucotomos can decrease the metabolism of midazolam by a mechanism possibly related to the inhibition of CYP3A4. However, a small study in humans suggests that taking Polypodium leucotomos with midazolam does not affect the metabolism of midazolam.

Likelihood Unlikely Evidence B
Polypodium leucotomos leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Polypodium Leucotomos Extract 1000 mg, from the product label.

SuperSmart

See all SuperSmart products
Name
SN Worldwide Unipessoal, LDA
Street Address
Avenida Do Infante 66 Edificio Quinta Avenida 1 C
City
Funchal
ZipCode
9000-015
Pharmacist Counseling Corner

Polypodium Leucotomos Extract 1000 mg by SuperSmart: Common Questions

Does Polypodium Leucotomos Extract 1000 mg by SuperSmart interact with any medications?
Yes. Based on its ingredients, Polypodium Leucotomos Extract 1000 mg has a known interaction with 643 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Polypodium Leucotomos Extract 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Polypodium Leucotomos Extract safe to take while pregnant?
No. There isn't enough safety data to know whether it's safe in pregnancy, so avoidance is the safer choice. Talk with your doctor or pharmacist if you're pregnant or planning to become pregnant.
Is it safe while breastfeeding?
Safety while breastfeeding is unknown, so avoidance is recommended. Speak with your doctor or pharmacist if you're breastfeeding and considering this supplement.
What is Polypodium leucotomos?
It's an extract from a tropical fern that's been used in traditional medicine. It's proposed for various skin conditions and dementia, though the evidence for its effectiveness in these conditions isn't yet established.
Does it cause side effects?
It's generally well tolerated. The only side effect documented in studies is itching, and that's been rare. Long-term safety data is limited, so we don't have a complete picture of effects over time.
Why does it interact with so many medications?
It may slow down a major liver enzyme called CYP3A4 that your body uses to break down over 600 different drugs — from statins to blood pressure medications to allergy drugs. When that enzyme is slower, drug levels can build up in your blood. That's why it's critical to check your specific medications first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Polypodium Leucotomos Extract 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Polypodium Leucotomos Extract 1000 mg label
Go deeper

The Full Monographs Behind Polypodium Leucotomos Extract 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Polypodium Leucotomos

Interacts with 643 drugs

Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain light-triggered skin conditions. Some early research...

Read the full Polypodium Leucotomos monograph →
Sources

Sources & How We Checked

Polypodium Leucotomos Extract 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Polypodium Leucotomos 2 references
  1. Goh CL, Chuah SY, Tien S, Thng G, Vitale MA, Delgado-Rubin A. Double-blind, placebo-controlled trial to evaluate the effectiveness of Polypodium leucotomos extract in the treatment of melasma in Asian skin: a pilot study. J Clin Aesthet Dermatol 2018;11(3
  2. Shinya K, Nishimura Y, Ryu K, et al. Short-term administration of Polypodium leucotomos extract does not inhibit CYP3A4-mediated metabolism of midazolam in healthy subjects: an open-label, two-period, fixed-sequence study. Int J Dermatol 2022.

See these in context on the Polypodium Leucotomos monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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