Pomegranate 250 mg Ingredients & Drug Interactions
by DC
What is this page for?
First and foremost: checking Pomegranate 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pomegranate 250 mg is a dietary supplement by DC with 1 active ingredient. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, high blood pressure.Based on those ingredients, 922 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pomegranate extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pomegranate 250 mg by DC
Ask about any prescription or over-the-counter medication and we check it for interactions with Pomegranate 250 mg by DC — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pomegranate 250 mg by DC
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This capsule contains one active ingredient: pomegranate extract at 250 mg per dose. Pomegranate is a fruit that's been used traditionally and studied for effects on blood pressure and cholesterol.
The capsule also holds several inactive ingredients—rice flour, gelatin, silica, vegetable cellulose, and vegetable magnesium stearate—which are fillers and binders that help form and stabilize the capsule.
Does it work?
Couldn't assess
The evidence on pomegranate extract is mixed. For high blood pressure (hypertension), the data suggests it's possibly effective—pomegranate juice has been shown to modestly lower blood pressure in some studies.
For high cholesterol (hyperlipidemia), the evidence rates it as possibly ineffective, and one clinical trial actually reported that 2% of patients experienced an increase in cholesterol after pomegranate consumption. For blood sugar control (diabetes) and fatty liver disease, the evidence is either possibly ineffective or too limited to rate reliably.
How safe is it?
Well-documented data
Pomegranate fruit and juice in normal food amounts are generally well tolerated. This extract is a concentrated form, and while pomegranate fruit extract seems well tolerated in studies, the safety data for concentrated supplements is more limited than for whole fruit or juice—so use caution.
The most common side effects are mild and gastrointestinal: diarrhea and flatulence occurred in about 2% of people drinking pomegranate juice daily in one trial, and in 10% of those taking a larger extract dose (3,000 mg) in another. A small number of trial participants also reported nausea, abdominal pain, constipation, stomach upset, or vomiting at higher extract doses.
Pomegranate root, stem, and peel should not be used in large amounts.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you're on warfarin or other blood thinners, blood pressure medications (antihypertensives or ACE inhibitors), rosuvastatin or other cholesterol drugs, drugs metabolized by CYP2D6 enzymes in your liver, or carbamazepine (a seizure medication). Pomegranate may increase drug levels or blood-pressure-lowering effects, raising the risk of adverse outcomes.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Pomegranate extract may help with blood pressure, though the evidence is modest. If you take blood thinners, blood pressure medications, cholesterol drugs, or seizure medications, you'll want to discuss this supplement with your doctor or pharmacist before starting—interactions are documented and may affect how those drugs work.
For most people without those medications, the main concern is occasional mild stomach upset.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pomegranate 250 mg, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pomegranate 250 mg by DC, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pomegranate extract | 250 mg | -- |
Other ingredients: Rice Flour, Gelatin, Silica, Vegetable Cellulose, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take 1 capsule twice daily preferably with a meal.
Formula
Pomegranate contains important polyphenols that help promote antioxidant health and help fight cell damaging free radicals.
40% ellagic acid
Formulation
FDA Registered Facility (Reg. #1023013) Mfg. under Good Manufacturing Practices (GMPs)
Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.
Helps promote antioxidant health and helps fight cell damaging free radicals
Gluten free
Made in USA
Precautions
Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.
Keep out of reach of children.
Storage
Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
New size new strength
Seals/Symbols
Quali Pure
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pomegranate 250 mg by DC label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pomegranate 250 mg by DC
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Pomegranate extract
Interacts with922 drugs
Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...
Pomegranate extract monograph & interactionsOther (inactive) ingredients: Rice Flour, Gelatin, Silica, Vegetable Cellulose, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Pomegranate 250 mg by DC Drug Interactions
HelloPharmacist Interaction Report
Pomegranate 250 mg by DC interacts with several medication types through its pomegranate extract.
The most serious documented concern involves warfarin (a blood thinner), where pomegranate may theoretically increase drug levels and raise bleeding risk; a case report showed one patient maintained stable blood-thinning on warfarin while consuming pomegranate juice, but stopping regular intake might lower warfarin levels unpredictably.
Read the full breakdown — every affected drug type, severity by severity
Pomegranate extract also carries Moderate-severity interactions with blood pressure medications (antihypertensives and ACE inhibitors), since the extract itself may lower blood pressure and could compound that effect. It may raise levels of drugs broken down by CYP2D6 enzymes in your liver (Moderate severity), and theoretically increase adverse effects from rosuvastatin (a cholesterol drug)—one case reported muscle breakdown (rhabdomyolysis) in a patient taking rosuvastatin plus ezetimibe who drank pomegranate juice regularly, though that patient had a history of muscle-enzyme issues.
Minor interactions are documented with drugs metabolized by CYP2C9 and CYP3A4 enzymes, and with carbamazepine (a seizure medication), though research suggests these are unlikely to be clinically significant. Altogether, these interactions span 923 individual medications.
Check your exact medications with the tool on this page before starting, and discuss any concerns with your own doctor or pharmacist—especially if you take blood thinners, blood pressure drugs, or cholesterol medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pomegranate 250 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pomegranate 250 mg interact with 922 drugs. Click any drug to see the details.
1 of the 1 ingredient in Pomegranate 250 mg interact with drugs. Each result below shows which ingredient is responsible. Pomegranate extract
Aspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Aspirin, Hydrocodone interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Aspirin, Oxycodone interactionAtenololAtenix, Tenormin
How Atenolol interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Atenolol, Chlorthalidone interactionAtomoxetineStrattera
How Atomoxetine interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Atomoxetine interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Atropine, Meperidine interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Atropine, Morphine Sulfate interactionAzilsartanEdarbi
How Azilsartan interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Read the full Pomegranate Extract + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Azilsartan, Chlorthalidone interactionBenazeprilLotensin
How Benazepril interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAce Inhibitors (aceis), Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Read the full Pomegranate Extract + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs, Ace Inhibitors (aceis) Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract + Benzhydrocodone, Acetaminophen interactionBenzthiazideExna
How Benzthiazide interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs +1 Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract + Bosentan interactionBrexpiprazoleRexulti
How Brexpiprazole interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract + Brexpiprazole interactionBrompheniramine, Dextromethorphan, PhenylephrineDimetapp DM
How Brompheniramine, Dextromethorphan, Phenylephrine interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Brompheniramine, Dextromethorphan, Phenylephrine interactionBudesonide, FormoterolSymbicort
How Budesonide, Formoterol interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Budesonide, Formoterol interactionBumetanideBurinex
How Bumetanide interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bumetanide interactionBumetanide (iv)Bumex
How Bumetanide (iv) interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bumetanide (iv) interactionBumetanide (oral)Bumex
How Bumetanide (oral) interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bumetanide (oral) interactionBuproprion, DextromethorphanAuvelity
How Buproprion, Dextromethorphan interacts with Pomegranate 250 mg — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract + Buproprion, Dextromethorphan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pomegranate 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Pomegranate extract
Ace Inhibitors (Aceis)
Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.
Antihypertensive Drugs
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.
Rosuvastatin (Crestor)
Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.
Warfarin (Coumadin)
Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.
Carbamazepine (Tegretol)
Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.
Tolbutamide (Orinase)
Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.
Brand information
Manufacturer and brand details for Pomegranate 250 mg, from the product label.
DC
See all DC products- Name
- Dee Cee Laboratories, Inc.
- Street Address
- 304 Dee Cee Rd.
- City
- White House
- State
- TN
- ZipCode
- 37188
Pomegranate 250 mg by DC: Common Questions
Does Pomegranate 250 mg by DC interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take pomegranate extract if I'm on a blood thinner like warfarin?
Will this help my blood pressure?
Can I take this if I'm pregnant or breastfeeding?
What are the most common side effects?
Will this help with high cholesterol?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pomegranate 250 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pomegranate 250 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pomegranate 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Pomegranate 27 references
- Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
- Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
- Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
- Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
- Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8. PubMed
- Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. DOI
- Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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