Pomegranate Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Pomegranate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pomegranate is a dietary supplement by Earthborn Elements with 1 active ingredient. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, high blood pressure.Based on those ingredients, 922 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pomegranate extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pomegranate by Earthborn Elements
Ask about any prescription or over-the-counter medication and we check it for interactions with Pomegranate by Earthborn Elements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pomegranate by Earthborn Elements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This capsule contains one active ingredient: pomegranate extract. Pomegranate is a fruit long used in traditional medicine and eaten as food; the extract concentrates its active compounds, which include polyphenols.
The capsule itself is made of gelatin, an inactive ingredient that holds the extract. Because this is a concentrated extract rather than the whole fruit or juice, it delivers more potent doses than you'd get from eating a pomegranate or drinking the juice—which means you're getting a stronger effect, but also higher exposure to any interactions.
Does it work?
Moderate evidence
The evidence we hold shows pomegranate extract is possibly effective for high blood pressure (hypertension)—studies suggest it may help lower it modestly. For high cholesterol (hyperlipidemia) and diabetes, the data rates it as possibly ineffective.
For nonalcoholic fatty liver disease, we don't have enough reliable evidence to say whether it works or doesn't. If your goal is blood pressure support, there's some reason to think it might help, but talk with your doctor about whether it fits your overall plan.
How safe is it?
Well-documented data
Pomegranate fruit and juice are generally well tolerated as food. However, because this is a concentrated extract, the safety data we hold is more limited—we'd recommend caution with concentrated supplements.
The most common side effects in studies were mild: diarrhea and flatulence, reported in a small number of people taking high-dose extract. At very high doses or with root, stem, and peel preparations (not this product), nausea, abdominal pain, constipation, and vomiting were noted in a small number of trial participants.
For pregnancy and breastfeeding, the data rates pomegranate as possibly safe, but because there isn't enough information on concentrated extracts specifically, talk with your doctor or pharmacist before using this product if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before you take this product, check if you're on any blood pressure medications (antihypertensives), ACE inhibitors, warfarin or other blood thinners, or drugs broken down by your liver—especially those processed by CYP2D6 enzymes. These carry Moderate-severity interactions.
Also check if you take rosuvastatin, carbamazepine, or other drugs metabolized by CYP2C9 or CYP3A4 enzymes. Your pharmacist or doctor can tell you which category your medications fall into.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Pomegranate extract may help lower blood pressure, but it interacts with a wide range of medications—especially blood pressure drugs, blood thinners, and drugs your liver processes. If you take any prescription medication, check it against the interaction tool on this page and discuss the product with your doctor or pharmacist before starting.
Most people tolerate it well, though mild digestive upset is possible.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pomegranate, straight from the product label.
| Brand | Earthborn Elements |
|---|---|
| Net contents | 200 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 21, 2023 |
| DSLD ID | 283933 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pomegranate by Earthborn Elements, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: Take 1 capsule 2 to 3 times daily, with food, or as recommended by your healthcare professional. Take with at least 8 oz of liquid.
Precautions
If you are pregnant, nursing, or taking medication, consult your healthcare professional before taking this or any dietary supplement.
For adults only.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease or health condition.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pomegranate by Earthborn Elements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pomegranate by Earthborn Elements
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.
Pomegranate extract
Interacts with922 drugs
Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...
Pomegranate extract monograph & interactionsOther (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.
Pomegranate by Earthborn Elements Drug Interactions
HelloPharmacist Interaction Report
Pomegranate extract by Earthborn Elements interacts with several medication categories, and the most serious concerns involve blood pressure medications and blood thinners.
Through its pomegranate extract content, this product may increase the risk of low blood pressure (hypotension) if you're taking blood pressure–lowering drugs (antihypertensives), and it may raise bleeding risk if you're on warfarin (a blood thinner). Both interactions are rated Moderate.
Read the full breakdown — every affected drug type, severity by severity
The extract may also interfere with how your body processes certain drugs. It could theoretically increase blood levels of medications broken down by CYP2D6 enzymes (a Moderate concern), and it may have ACE inhibitor-like effects that could add to the blood pressure impact of ACE inhibitors—another Moderate-severity interaction.
Additionally, there's a case report of someone taking rosuvastatin (a statin) who developed muscle breakdown after consuming pomegranate juice, though that patient had other risk factors.
Several other drug categories are affected at Minor severity: those metabolized by CYP2C9 or CYP3A4 enzymes, and carbamazepine (an anti-seizure medication). Altogether, these interactions span 923 individual medications.
Check your exact prescriptions with the medication interaction checker on this page before you start pomegranate. If you take any blood pressure medicine, blood thinner, or drug metabolized by the liver, run it through the tool and talk with your doctor or pharmacist before adding this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pomegranate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pomegranate interact with 922 drugs. Click any drug to see the details.
1 of the 1 ingredient in Pomegranate interact with drugs. Each result below shows which ingredient is responsible. Pomegranate extract
Aspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Aspirin, Hydrocodone interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Aspirin, Oxycodone interactionAtenololAtenix, Tenormin
How Atenolol interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Atenolol, Chlorthalidone interactionAtomoxetineStrattera
How Atomoxetine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Atomoxetine interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Atropine, Meperidine interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Atropine, Morphine Sulfate interactionAzilsartanEdarbi
How Azilsartan interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Read the full Pomegranate Extract + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Azilsartan, Chlorthalidone interactionBenazeprilLotensin
How Benazepril interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAce Inhibitors (aceis), Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Read the full Pomegranate Extract + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs, Ace Inhibitors (aceis) Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract + Benzhydrocodone, Acetaminophen interactionBenzthiazideExna
How Benzthiazide interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs +1 Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract + Bosentan interactionBrexpiprazoleRexulti
How Brexpiprazole interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract + Brexpiprazole interactionBrompheniramine, Dextromethorphan, PhenylephrineDimetapp DM
How Brompheniramine, Dextromethorphan, Phenylephrine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Brompheniramine, Dextromethorphan, Phenylephrine interactionBudesonide, FormoterolSymbicort
How Budesonide, Formoterol interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Extract + Budesonide, Formoterol interactionBumetanideBurinex
How Bumetanide interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bumetanide interactionBumetanide (iv)Bumex
How Bumetanide (iv) interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bumetanide (iv) interactionBumetanide (oral)Bumex
How Bumetanide (oral) interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Extract + Bumetanide (oral) interactionBuproprion, DextromethorphanAuvelity
How Buproprion, Dextromethorphan interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Extract + Buproprion, Dextromethorphan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pomegranate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Pomegranate extract
Ace Inhibitors (Aceis)
Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.
Antihypertensive Drugs
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.
Rosuvastatin (Crestor)
Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.
Warfarin (Coumadin)
Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.
Carbamazepine (Tegretol)
Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.
Tolbutamide (Orinase)
Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.
Brand information
Manufacturer and brand details for Pomegranate, from the product label.
Earthborn Elements
See all Earthborn Elements products- Name
- Earthborn Elements
- Street Address
- 9450 SW Gemini Dr., #49936
- City
- Beaverton
- State
- OR
- ZipCode
- 97008
- Web Address
- Earthbornelements.com
Pomegranate by Earthborn Elements: Common Questions
Does Pomegranate by Earthborn Elements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will pomegranate extract really lower my blood pressure?
What are the side effects I should watch for?
Is it safe to take if I'm pregnant or breastfeeding?
What makes pomegranate extract different from eating the fruit?
Can I take this with my other supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pomegranate is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pomegranate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pomegranate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Pomegranate 27 references
- Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
- Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
- Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
- Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
- Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8. PubMed
- Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. DOI
- Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
- Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64. PubMed
- Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 2002;71:203-17. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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