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Dietary supplement

DIM SGS+: DIM, Hormone + Detox Ingredients & Drug Interactions

by Simlike

DIM SGS+: DIM, Hormone + Detox label
See full label image
Capsule Category: Herbal/dietary Supplement
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Jul 27, 2026 · Label data verified by our pharmacy team
What is this page for?

First and foremost: checking DIM SGS+: DIM, Hormone + Detox against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DIM SGS+: DIM, Hormone + Detox is a dietary supplement by Simlike with 3 active ingredients. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, high blood pressure.Based on those ingredients, 1,169 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Pepper fruit extract, Pomegranate powder, Diindolylmethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Ask about any prescription or over-the-counter medication and we check it for interactions with DIM SGS+: DIM, Hormone + Detox by Simlike — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DIM SGS+: DIM, Hormone + Detox by Simlike

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

DIM SGS+ contains three active ingredients. Pomegranate powder brings polyphenol antioxidants; black pepper fruit extract supplies piperine, a compound that may enhance absorption of other ingredients; and diindolylmethane (DIM) is a compound derived from cruciferous vegetables like broccoli.

There are no inactive other ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: hormone balance and estrogen metabolism support.
  • We looked for evidence on: Menopausal symptoms, Premenstrual syndrome (PMS), Polycystic ovary syndrome (PCOS), Dysmenorrhea, Hormonal acne, Hormonal imbalance — and 1 related terms.
  • The closest evidence on file: Pomegranate is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms (Natural Medicines).
  • Also on file: Pomegranate is rated "Insufficient Reliable Evidence To Rate" for Polycystic ovary syndrome (PCOS).
  • Also on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Dysmenorrhea.

The data we hold shows limited evidence for these ingredients' effectiveness. Pomegranate is rated possibly effective for high blood pressure but possibly ineffective for high cholesterol and diabetes.

Black pepper extract has insufficient reliable evidence for conditions like hay fever, asthma, headache, and depression. Diindolylmethane also lacks established evidence for prostate health, breast or uterine cancer, cervical dysplasia, colorectal cancer, or breast pain.

The product's specific hormone and detox claims are not addressed in the effectiveness data available to us.

The evidence, ingredient by ingredient Pomegranate Black Pepper Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pomegranate fruit and juice are generally well tolerated as food, though concentrated extracts warrant caution due to limited safety data. The most common side effects are diarrhea and flatulence; at high extract doses, some people experienced nausea, abdominal pain, constipation, or vomiting.

Black pepper is well tolerated in food amounts and single medicinal doses, with burning aftertaste and indigestion as typical mild effects; rare allergic reactions have been reported. Diindolylmethane is generally well tolerated in short-term use, causing diarrhea, gas, headache, nausea, rash, or vomiting in some users; long-term safety is not well established.

For pregnancy, pomegranate is rated possibly safe, and diindolylmethane is rated likely safe. Black pepper is rated likely safe in pregnancy but likely unsafe for lactation, and diindolylmethane safety data during breastfeeding are insufficient to make a recommendation—talk with your doctor or pharmacist about breastfeeding while using this product.

Side effects, ingredient by ingredient Pomegranate Black Pepper Diindolylmethane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Pomegranate, Black Pepper, Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,170 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you use blood thinners like warfarin, blood pressure or heart medications (including propranolol, ACE inhibitors, or antihypertensive drugs), epilepsy drugs (phenytoin, carbamazepine), estrogen-based therapies or hormone replacement, cholesterol medications (atorvastatin, rosuvastatin), antivirals (nevirapine), tuberculosis drugs (rifampin), water pills (diuretics), immunosuppressants (cyclosporine), sedatives (pentobarbital), or theophylline. These carry documented Moderate or Minor interactions with the product's ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This three-ingredient supplement has a broad interaction footprint, especially with blood thinners, heart and blood pressure drugs, anticonvulsants, and certain cholesterol and antiviral medications. If you take any prescription medications—particularly warfarin, phenytoin, or estrogen-based therapies—check with your doctor or pharmacist before starting.

The evidence for its effectiveness is limited or absent. If you're considering it, discuss it with your own healthcare provider to weigh the risks and benefits for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2026.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DIM SGS+: DIM, Hormone + Detox, straight from the product label.

Brand Simlike
Barcode (UPC) 797417435456
Net contents 60 Capsules
Market status On market
Added to our catalog Jul 27, 2026
Product type Herbal/dietary Supplement
Supplement form Capsule
Dietary claims / uses Hormone balance, Estrogen metabolism support, Detox / natural cleansing, Occasional cravings management
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DIM SGS+: DIM, Hormone + Detox by Simlike, compiled by our pharmacy team from the manufacturer's label.

Supplement Facts

Daily Value (DV) Target Group(s):
N/A
Minimum serving Sizes:
1 Capsule
Maximum serving Sizes:
1 Capsule
Servings per container
60
UPC/BARCODE
797417435456
IngredientAmount% DV
Pomegranate powder100 mg--
Black Pepper fruit extract2.5 mg--
Diindolylmethane200 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested Use

Take 1 capsule one or two times daily with food, or as recommended by your healthcare practitioner

take 1 CAPSULE daily with a meal or as directed by your healthcare professional

Warnings

KEEP OUT OF REACH OF CHILDREN. If pregnant, nursing, or trying to conceive, consult your healthcare practitioner before using this product

Storage

TAMPER EVIDENT: Use only if bottle is sealed. Store tightly sealed in a cool, dry place.

Marketing

"HORMONE + DETOX"

Supports Balanced Hormonal Pathways

Helps Manage Occasional Cravings

Assists the Body's Natural Cleansing Processes

This unique blend of compounds aids in enhancing the metabolism of estrogen, thereby contributing to regulating the balance of healthy and unhealthy forms of estrogen.

The formula is developed with a focus on assisting hormone optimization and the use of bioidentical hormone replacement (BHRT)

Other

FREE FROM: Soy, Dairy, Gluten

Distributed by: BESSTO INC. 1312 17th St Unit Num2955 Denver CO 80202

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DIM SGS+: DIM, Hormone + Detox by Simlike label

The product's label imagery, on file with our pharmacy team. Tap to enlarge.

DIM SGS+: DIM, Hormone + Detox label

Label images reflect the product version on file with our pharmacy team. Always read your actual product label.

What’s inside

The Ingredients in DIM SGS+: DIM, Hormone + Detox by Simlike

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pomegranate powder

Interacts with
922 drugs
100 mg per serving Form: Extract (whole fruit)

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...

Pomegranate powder monograph & interactions

Black Pepper fruit extract

Interacts with
1,019 drugs
2.5 mg per serving Form: fruit extract

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

Black Pepper fruit extract monograph & interactions

Diindolylmethane

Interacts with
269 drugs
200 mg per serving Form: Crystalline DIM

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolylmethane monograph & interactions
Interaction report

DIM SGS+: DIM, Hormone + Detox by Simlike Drug Interactions

Want to check YOUR meds against DIM SGS+: DIM, Hormone + Detox?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,169Drugs
1,110 Moderate 59 Minor

Ingredients driving the most interactions

Black Pepper fruit extract 1,019
Pomegranate powder 922
Diindolylmethane 269

Individual Drug Interactions

The ingredients in DIM SGS+: DIM, Hormone + Detox interact with 1,169 drugs. Click any drug to see the details.

3 of the 3 ingredients in DIM SGS+: DIM, Hormone + Detox interact with drugs. Each result below shows which ingredient is responsible. Black Pepper fruit extract Pomegranate powder Diindolylmethane

Each ingredient & the kinds of drugs it affects

For each ingredient in DIM SGS+: DIM, Hormone + Detox with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Pepper fruit extract17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Black Pepper fruit extract full monograph & interactions

Pomegranate powder9 drug types · 922 drugs

Ace Inhibitors (Aceis)

Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.

Likelihood Possible Evidence D
Rosuvastatin (Crestor)

Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.

Likelihood Unlikely Evidence B
Tolbutamide (Orinase)

Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.

Likelihood Unlikely Evidence D
Pomegranate powder full monograph & interactions

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DIM SGS+: DIM, Hormone + Detox, from the product label.

Simlike

See all Simlike products
Pharmacist Counseling Corner

DIM SGS+: DIM, Hormone + Detox by Simlike: Common Questions

Does DIM SGS+: DIM, Hormone + Detox by Simlike interact with any medications?
Yes. Based on its ingredients, DIM SGS+: DIM, Hormone + Detox has a known interaction with 1,169 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DIM SGS+: DIM, Hormone + Detox contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does pomegranate in this product raise blood pressure?
No—pomegranate is rated possibly effective for lowering high blood pressure. However, if you already take blood pressure medications, pomegranate might lower your pressure further, so check with your doctor or pharmacist before combining them.
Can I take this if I'm on birth control or hormone replacement therapy?
The diindolylmethane in this product may theoretically interfere with estrogens or hormone replacement therapy. Talk with your doctor or pharmacist before starting, especially if you rely on hormonal birth control or HRT for your health.
Is this safe during pregnancy?
Pomegranate is rated possibly safe in pregnancy, and diindolylmethane is rated likely safe. However, black pepper's pregnancy safety data are mixed. Because long-term safety of diindolylmethane in pregnancy isn't well established, talk with your doctor or pharmacist before using this product while pregnant.
What side effects might I notice?
The most common side effects are diarrhea, gas, and nausea. At higher doses, some people report headache, vomiting, abdominal pain, or a burning aftertaste. Rare allergic reactions to black pepper have been reported in sensitive individuals.
Does this product actually help with hormone balance or detoxification?
The evidence we hold does not establish effectiveness for either claim. Pomegranate, black pepper, and diindolylmethane all lack reliable evidence supporting their use for those purposes in the data available to us.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DIM SGS+: DIM, Hormone + Detox label
Go deeper

The Full Monographs Behind DIM SGS+: DIM, Hormone + Detox’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pomegranate

Interacts with 922 drugs

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support heart health and blood pressure, but the evi...

Read the full Pomegranate monograph → Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph →
Sources

Sources & How We Checked

DIM SGS+: DIM, Hormone + Detox's label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pomegranate 27 references
  1. Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
  2. Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
  3. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
  4. Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
  5. Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8. PubMed
  6. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. DOI
  7. Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
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Diindolylmethane 14 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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