Major interaction on record — check this product against your medications before combining. Based on 7 of 11 ingredients. Check your meds →
Dietary supplement

Post Protocol Fruit Punch Ingredients & Drug Interactions

by Bodybuilding.com Platinum Series

Post Protocol Fruit Punch label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Post Protocol Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Post Protocol Fruit Punch is a dietary supplement by Bodybuilding.com Platinum Series with 11 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 1,427 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Ashwagandha, Sodium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Post Protocol Fruit Punch by Bodybuilding.com Platinum Series

Ask about any prescription or over-the-counter medication and we check it for interactions with Post Protocol Fruit Punch by Bodybuilding.com Platinum Series — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Post Protocol Fruit Punch by Bodybuilding.com Platinum Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Post Protocol Fruit Punch contains 10 active ingredients. The backbone is three branched-chain amino acids—L-leucine, L-isoleucine, and L-valine—along with L-glutamine, which supports muscle recovery and immune function.

It also includes calcium for bone health, sodium for electrolyte balance, ashwagandha (an adaptogenic herb), creatine hydrochloride for muscle strength and performance, L-carnitine L-tartrate to support fat metabolism and energy, and CherryPure tart cherry powder for antioxidant and recovery support. The powder also contains inactive ingredients (fillers and flavor) including malic acid, sucralose, citric acid, natural and artificial flavors, calcium silicate, a soybean oil and lecithin blend, acesulfame potassium, and FD&C Red #40.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Post-workout muscle recovery and repair.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle strength and size, Sports recovery.
  • The strongest evidence on file: Sour Cherry is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance, Muscle strength.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.

Evidence for effectiveness varies across the ingredients. Glutamine is rated Effective for sickle cell disease and Possibly Effective for HIV-related wasting, postoperative recovery, and critical illness.

Calcium is Effective for kidney failure and dyspepsia, and Likely Effective for osteoporosis. Sodium is Likely Effective for cystic fibrosis and Possibly Effective for amphotericin B side effects.

Ashwagandha is Possibly Effective for insomnia, anxiety, stress, and generalized anxiety disorder. Creatine is Possibly Effective for muscle strength, athletic performance, and sarcopenia.

L-carnitine is Effective for carnitine deficiency and Possibly Effective for high cholesterol, heart failure, and angina. Tart cherry is Possibly Effective for athletic performance, though evidence for ADHD, cognition, muscle soreness, and other uses is insufficient.

The combination is marketed as a post-workout formula, but the facts here don't specify an overall effectiveness rating for recovery or muscle building as a complete product.

The evidence, ingredient by ingredient Glutamine Calcium Sodium Ashwagandha Creatine L-carnitine Sour Cherry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glutamine is generally well tolerated but should only be used under medical supervision in people with kidney or liver disease; it carries cautions for pregnancy and breastfeeding. Common side effects include bloating, gas, nausea, and GI upset; rare cases of dizziness or mood changes have been reported.

Calcium at recommended doses is generally safe, though high doses raise theoretical concerns about kidney stones and prostate cancer risk; it is Likely Safe in pregnancy and Possibly Unsafe in certain contexts. Sodium is generally safe at normal dietary levels but cautions against excess; it is Likely Safe in pregnancy and Possibly Unsafe at high doses.

Ashwagandha is well tolerated short-term but is Likely Unsafe in pregnancy and should be avoided while breastfeeding; rare cases of liver damage have been reported. Creatine is generally well tolerated but should be avoided in pregnancy and lactation; common effects include water retention, muscle cramps, and GI upset.

L-carnitine is well tolerated at typical doses and Possibly Safe while breastfeeding, though pregnancy safety is not established. Tart cherry is Likely Safe in pregnancy and lactation and well tolerated as a food, though concentrated supplements are less studied; GI upset and loose stools are the most common effects.

Side effects, ingredient by ingredient Glutamine Calcium Sodium Ashwagandha Creatine L-carnitine Sour Cherry

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 7 matched ingredients can interact with medications — Calcium, Glutamine, Ashwagandha, L-carnitine, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,428 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before use if you take any HIV medications (especially dolutegravir, elvitegravir, raltegravir), blood pressure medications, blood thinners (warfarin), thyroid hormone (levothyroxine), diabetes medications, seizure medications (anticonvulsants), sedatives or benzodiazepines, corticosteroids, lithium, heart medications (sotalol, diltiazem), or any drugs that stress the liver. The interactions are Moderate to Major in severity; no interactions are documented for L-leucine, L-isoleucine, or L-valine, which we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a recovery-focused amino acid and supplement blend geared toward athletes and people doing intense training. Because of interactions with HIV medications, blood thinners, blood pressure drugs, thyroid hormone, diabetes medications, seizure medications, and several others, you'll want to check every medication you take with the tool on this page before starting.

If you have kidney or liver disease, take any of the at-risk medications, or are pregnant or breastfeeding, talk with your doctor or pharmacist first—don't start without their input.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Post Protocol Fruit Punch, straight from the product label.

Brand Bodybuilding.com Platinum Series
Barcode (UPC) 000766
Net contents 0.98 lbs; 446.6 Gram(s)
Market status On market
Date entered into DSLD Sep 22, 2016
DSLD ID 64287
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Post Protocol Fruit Punch by Bodybuilding.com Platinum Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
22 Gram(s)
Maximum serving Sizes:
22 Gram(s)
Servings per container
20
UPC/BARCODE
000766
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
L-Glutamine5 Gram(s)--
Sugar0 Gram(s)--
Calcium50 mg5%
Total Fat0 Gram(s)--
L-Leucine6 Gram(s)--
L-Isoleucine2 Gram(s)--
L-Valine2 Gram(s)--
Sodium190 mg8%
Ashwagandha600 mg--
Creatine Hydrochloride1.5 Gram(s)--
L-Carnitine L-Tartrate1 Gram(s)--
CherryPure Tart Cherry powder500 mg--

Other ingredients: Natural & Artificial flavors, Malic Acid, Sucralose, Citric Acid, Calcium Silicate, Soybean Oil & Lecithin Blend, Acesulfame Potassium, FD&C Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Post Protocol: Recover. Repair. Rebuild Your recovery protocol to rebuild and replenish muscles fast Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study.

Post Workout Size Recovery Strength

Naturally and artificially flavored

Advanced Post-Workout Recovery Matrix

Platinum Series

Reduced exercised-induced muscle damage Muscle Soreness (Min) Time Placebo BCAA Delayed onset muscle soreness before and up to 96h after the damaging bout of exercise Denotes a significant group effect. Values are means ± SD;N=12. J Int Soc Sports Nutr. 2012; 9: 20. Published online 2012 July 12. doi: 10.1186/1550-2783-9-20 Increased Maximal Force MVC (Baseline) Time Placebo BCAA Maximal voluntary force before and up to 96 hr after the damaging bout of exercise. Denotes a significant group effect. Values are means ± SD;N=12. J Int Soc Sports Nutr. 2012; 9: 20. Published online 2012 July 12. doi: 10.1186/1550-2783-9-20

Clinically Researched Ingredients

BBCOM766 - 3007V3

Brand IP Statement(s)

Caripure's a high quality L-carnitine manufactured by Lonza. Patent #945,004,345.

CherryPURE is a resisted trademark of Shoreline Fruit, LLC.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

10 G BCAAs 6 G Leucine

5 G Glutamine 1.5 G Creatine HCl

Allergen Warning: Contains milk and soy and is produced in a facility that also processes peanuts, eggs and wheat.

FDA Statement of Identity

Dietary Supplement

Formulation

0 Sugar

Precautions

Allergen Warning: Contains milk and soy and is produced in a facility that also processes peanuts, eggs and wheat.

Warnings: Keep out of reach of children. Check with a qualified health care professional before taking this product if you are pregnant or nursing a baby, under 18 years of age, have any known or suspected medical conditions, and/or if you are taking any prescription or OTC medications.

Check with a qualified health care professional before taking this product if you are pregnant or nursing a baby, under 18 years of age, have any known or suspected medical conditions, and/or if you are taking any prescription or OTC medications.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement take 2 scoops with 8-12oz. of cold water immediately post-workout.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Post Protocol Fruit Punch by Bodybuilding.com Platinum Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Post Protocol Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Post Protocol Fruit Punch by Bodybuilding.com Platinum Series

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size22 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
5 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Sugar

0 Gram(s) per serving

Calcium

Interacts with
168 drugs
50 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

L-Leucine

6 Gram(s) per serving

L-Isoleucine

2 Gram(s) per serving

L-Valine

2 Gram(s) per serving

Sodium

Interacts with
205 drugs
190 mg per serving Form: Sodium Chloride

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Ashwagandha

Interacts with
1,372 drugs
600 mg per serving

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Ashwagandha monograph & interactions

Creatine Hydrochloride

No known
interactions
1.5 Gram(s) per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine Hydrochloride monograph & interactions

L-Carnitine L-Tartrate

Interacts with
19 drugs
1 Gram(s) per serving

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...

L-Carnitine L-Tartrate monograph & interactions

CherryPure Tart Cherry powder

No known
interactions
500 mg per serving

Sour cherry (often sold as tart cherry or Montmorency cherry) is a fruit-based supplement rich in antioxidants that people use for muscle recovery, jo...

CherryPure Tart Cherry powder monograph & interactions

Other (inactive) ingredients: Natural & Artificial flavors, Malic Acid, Sucralose, Citric Acid, Calcium Silicate, Soybean Oil & Lecithin Blend, Acesulfame Potassium, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Post Protocol Fruit Punch by Bodybuilding.com Platinum Series Drug Interactions

Want to check YOUR meds against Post Protocol Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,427Drugs
7 Major 978 Moderate 442 Minor

Ingredients driving the most interactions

Ashwagandha 1,372
Sodium 205
Calcium 168
L-Glutamine 50
L-Carnitine L-Tartrate 19

Individual Drug Interactions

The ingredients in Post Protocol Fruit Punch interact with 1,427 drugs. Click any drug to see the details.

5 of the 11 ingredients in Post Protocol Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha Sodium Calcium L-Glutamine L-Carnitine L-Tartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Post Protocol Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ashwagandha10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Ashwagandha full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

L-Carnitine L-Tartrate3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.

Likelihood Possible Evidence D
L-Carnitine L-Tartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Post Protocol Fruit Punch, from the product label.

Bodybuilding.com Platinum Series

See all Bodybuilding.com Platinum Series products
Name
Bodybuilding.com
Street Address
5957 W. Vandal Rd. Ste. A
City
Boise
State
ID
ZipCode
83709
Phone Number
1-866-236-8417
Pharmacist Counseling Corner

Post Protocol Fruit Punch by Bodybuilding.com Platinum Series: Common Questions

Does Post Protocol Fruit Punch by Bodybuilding.com Platinum Series interact with any medications?
Yes. Based on its ingredients, Post Protocol Fruit Punch has a known interaction with 1,427 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Post Protocol Fruit Punch contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant or breastfeeding?
Ashwagandha is considered Likely Unsafe in pregnancy and should be avoided. Glutamine, creatine, and L-carnitine lack reliable safety data in pregnancy—best avoided unless your doctor specifically recommends them. Calcium and tart cherry are Likely Safe in pregnancy at normal amounts. For breastfeeding, ashwagandha and creatine should be avoided, glutamine and L-carnitine lack adequate safety data, but calcium and tart cherry are considered safe. Talk with your doctor or pharmacist about any prenatal or lactation concerns before using this product.
What does ashwagandha do in this formula?
Ashwagandha is an adaptogenic herb rated Possibly Effective for insomnia, anxiety, stress, and generalized anxiety disorder. In a post-workout powder, it may help with recovery and stress management. However, be aware it can theoretically increase the sedative effects of sleep aids and other CNS depressants, and lower blood pressure.
Why does this product have calcium and sodium in it?
Calcium supports bone health and is rated Likely Effective for osteoporosis. Sodium is an electrolyte lost through sweat during exercise and is needed to maintain fluid balance. However, calcium and sodium both have documented interactions with several medications, so check your prescriptions before starting.
What are the common side effects of taking this powder?
The most common adverse effects from the ingredients are gastrointestinal—bloating, gas, nausea, diarrhea, and stomach upset from glutamine and tart cherry. Creatine may cause water retention and muscle cramps. L-carnitine can cause a fish-like body odor at higher doses. These effects are typically mild and dose-dependent.
Can I use this if I have kidney problems?
Glutamine and creatine both require caution in people with kidney or liver disease and should only be used under medical supervision if you have these conditions. Talk with your doctor or pharmacist before taking this product if you have any kidney or liver issues.
Does this product actually help with muscle recovery and athletic performance?
The individual ingredients have mixed evidence. Creatine is Possibly Effective for muscle strength and athletic performance. L-carnitine is Possibly Effective for congestive heart failure and may support energy metabolism. Tart cherry is Possibly Effective for athletic performance. Glutamine is Possibly Effective for postoperative recovery. However, the product facts provided do not include an overall clinical effectiveness rating for the complete formula as a recovery aid.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Post Protocol Fruit Punch is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Post Protocol Fruit Punch label
Go deeper

The Full Monographs Behind Post Protocol Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

L-carnitine

Interacts with 19 drugs

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...

Read the full L-carnitine monograph → Herb & supplement monograph

Sour Cherry

Sour cherry (often sold as tart cherry or Montmorency cherry) is a fruit-based supplement rich in antioxidants that people use for muscle recovery, joint and gout symptoms, and sleep. Early...

Read the full Sour Cherry monograph →
Sources

Sources & How We Checked

Post Protocol Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 274 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
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  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Calcium 62 references
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  30. Rocephin (ceftriaxone) and calcium interaction. Pharmacist's Letter / Prescriber's Letter 2007;23(10):231005.
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See these in context on the Calcium monograph →

Sodium 38 references
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Sour Cherry 4 references
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See these in context on the Sour Cherry monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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