Major interaction on record — check this product against your medications before combining. Based on 7 of 10 ingredients. Check your meds →
Dietary supplement

Pre-Workout Blue Raspberry Ring Pop Ingredients & Drug Interactions

by Ryse

Pre-Workout Blue Raspberry Ring Pop label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pre-Workout Blue Raspberry Ring Pop against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Pre-Workout Blue Raspberry Ring Pop is a dietary supplement by Ryse with 10 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 797 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Caffeine Anhydrous, Sodium, L-Taurine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pre-Workout Blue Raspberry Ring Pop by Ryse

Ask about any prescription or over-the-counter medication and we check it for interactions with Pre-Workout Blue Raspberry Ring Pop by Ryse — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pre-Workout Blue Raspberry Ring Pop by Ryse

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Ryse Pre-Workout Blue Raspberry Ring Pop contains 10 active ingredients. The electrolytes are sodium and potassium—minerals your body needs for muscle function and nerve signaling, though this product's sodium content is worth watching if you're on blood pressure medication.

Caffeine anhydrous (a concentrated, water-free form of caffeine) and zumXR (extended-release caffeine) both boost mental focus and athletic performance. L-taurine supports muscle endurance and heart health.

Betaine anhydrous, choline, and beta-alanine are amino acid derivatives: betaine may help muscle strength, choline supports nerve function, and beta-alanine is used by athletes for endurance. Thinkamine and NO3-T are proprietary blends we couldn't fully evaluate.

The powder also contains inactive ingredients—malic acid, sodium bicarbonate, flavoring, potassium bicarbonate, sucralose, tartaric acid, and acesulfame potassium—which are fillers and flavor agents.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: energy and athletic performance.
  • We looked for evidence on: Athletic performance, Fatigue, Mental alertness, Exercise-induced muscle soreness, Exercise-induced muscle breakdown, endurance — and 2 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Beta-alanine is rated "Possibly Effective" for Athletic performance.

Caffeine in this product is likely effective for mental alertness and athletic performance, and effective for certain neonatal conditions and postoperative headache. Beta-alanine is possibly effective for athletic and physical performance.

Betaine anhydrous is effective for a rare genetic condition (homocystinuria) and possibly effective for elevated homocysteine, though evidence is mixed or insufficient for its use in heart health, liver disease, depression, and reflux. L-taurine is possibly effective for congestive heart failure and certain types of hepatitis.

Choline's effectiveness for cognitive decline, allergies, and liver issues in hospitalized patients is not yet established in the data we hold. Potassium and sodium have established uses for specific medical conditions (cystic fibrosis, electrolyte replacement) but their roles in a pre-workout supplement are not addressed here.

The evidence, ingredient by ingredient Sodium Potassium Caffeine Taurine Betaine Anhydrous Choline Beta-alanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine is generally well tolerated in moderate amounts but can cause anxiety, insomnia, jitteriness, tremor, and headache—and rarely, stroke. High doses carry serious risk.

Sodium is fine in normal dietary amounts but excess is linked to high blood pressure, heart strain, and worsening kidney disease; this product's sodium content means you should not add more from other sources without checking with your doctor. Potassium from food is safe, but supplements can cause dangerously high blood levels, especially in people with kidney disease or on certain medications; common side effects include stomach pain, diarrhea, and nausea, and rarely serious heart rhythm problems.

L-taurine is generally well tolerated short-term in healthy people, though long-term safety at high doses is less certain; rare reports link it to allergic reactions and, in one case, mania (though that involved an energy drink with multiple ingredients). Beta-alanine commonly causes harmless tingling and flushing of the skin.

Betaine anhydrous is generally well tolerated but can cause body odor, nausea, diarrhea, and rarely elevated cholesterol. Choline is well tolerated in normal amounts but high doses (over 3.5 grams daily) can cause fishy body odor, nausea, vomiting, and diarrhea.

Side effects, ingredient by ingredient Sodium Potassium Caffeine Taurine Betaine Anhydrous Choline Beta-alanine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 7 matched ingredients can interact with medications — Choline, Potassium, Caffeine, Taurine, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 797 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist if you take ephedrine or any stimulant (Major risk with the caffeine in this product). Also double-check blood pressure medications, lithium, seizure or sleep drugs, psychiatric medications (especially clozapine), stomach acid reducers (cimetidine), antibiotic fluoroquinolones, potassium-sparing diuretics, ACE inhibitors, ARBs, corticosteroids, or any sodium-containing products.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This pre-workout is mainly for athletes seeking mental focus and endurance during exercise. If you take blood pressure medications, lithium, seizure drugs, sleep aids, psychiatric medications, or have kidney disease or are on a potassium-restricting diet, check your exact medications with your doctor or pharmacist before starting.

Healthy people without those conditions can generally tolerate the caffeine and amino acids, though skin tingling from beta-alanine and body odor from betaine are common. Talk it over with your own doctor or pharmacist to make sure it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pre-Workout Blue Raspberry Ring Pop, straight from the product label.

Brand Ryse
Barcode (UPC) 854050008970
Net contents 313 Gram(s); 11 Ounce(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 299227
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pre-Workout Blue Raspberry Ring Pop by Ryse, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
12.5 Gram(s)
Maximum serving Sizes:
12.5 Gram(s)
Servings per container
25
UPC/BARCODE
854050008970
IngredientAmount% DV
Sodium140 mg6%
Potassium130 mg2%
Caffeine Anhydrous150 mg--
L-Taurine1.5 Gram(s)--
Betaine Anhydrous2 Gram(s)--
Choline200 mg35%
Beta-Alanine3.2 Gram(s)--
Thinkamine10 mg--
NO3-T1.5 Gram(s)--
zumXR70 mg--

Other ingredients: Malic Acid, Sodium Bicarbonate, Natural and Artificial flavors, Potassium Bicarbonate, Sucralose, L-Tartaric Acid, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

1 Pump 2 Energy 3 Strength Advanced Benefits of Ryse Up Pre-Workout

Nostalgic Flavor!

General Statements

Follow us on social @Ryse_Supps Scan Me Facebook Tiktok Instagram Youtube www.Rysesupps.com Element series

Ryse Up Supplements

Brand IP Statement(s)

NO3-T is a registered trademark of Thermolife International, LLC. For Patent Information, please visit www.No3-T.com/Patents

ZumXR is a registered trademark of Plt health solutions Copyright The Bazooka Companies, Inc. All Rights Reserved. Ring Pop is a registered trademark of the bazooka companies, Inc. Licensed by the Bazooka Companies, Inc.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Ryse Up Energy Guide 200 MG Caffeine Per Scoop 1.5 G NO3-T Nitrates Per Scoop 10 MG Thinkamine Per Scoop Suggested Use: Mix 1 Scoop with 10-12 oz. of water & consume 15-30 min. Prior to exercise. Vary amount of liquid to taste. Do not exceed one serving per day.

Formula

Thinkamine ZumXR

Blue raspberry ring pop Natural and artificial flavor

Precautions

Warning: Ryse Up Products are intended only for healthy adults over the age of 18.

Do not use if you are currently pregnant or nursing, could be pregnant, or are attempting to become pregnant.

Consult a licensed healthcare practitioner before using this product. Discontinue use and contact a doctor immediately if you experience an irregular or rapid heart beat, chest pain, shortness of breath, dizziness, lightheadedness, fainting or presyncope, tremors, headache, nausea, or other similar symptoms. If you are a performance athlete please check with your sanctioning body prior to use to ensure compliance.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pre-Workout Blue Raspberry Ring Pop by Ryse label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pre-Workout Blue Raspberry Ring Pop label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pre-Workout Blue Raspberry Ring Pop by Ryse

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size12.5 Gram(s) Dosage formPowder Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
140 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
130 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Caffeine Anhydrous

Interacts with
655 drugs
150 mg per serving

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredn...

Caffeine Anhydrous monograph & interactions

L-Taurine

Interacts with
173 drugs
1.5 Gram(s) per serving

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements,...

L-Taurine monograph & interactions

Betaine Anhydrous

No known
interactions
2 Gram(s) per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

Choline

Interacts with
16 drugs
200 mg per serving Form: Choline Bitartrate

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Beta-Alanine

No known
interactions
3.2 Gram(s) per serving

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-int...

Beta-Alanine monograph & interactions

Thinkamine

10 mg per serving Form: Vincamine

NO3-T

1.5 Gram(s) per serving Form: Arginine Nitrate

ZumXR

Interacts with
655 drugs
70 mg per serving Form: Caffeine, Delayed Release

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredn...

ZumXR monograph & interactions

Other (inactive) ingredients: Malic Acid, Sodium Bicarbonate, Natural and Artificial flavors, Potassium Bicarbonate, Sucralose, L-Tartaric Acid, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pre-Workout Blue Raspberry Ring Pop by Ryse Drug Interactions

Want to check YOUR meds against Pre-Workout Blue Raspberry Ring Pop?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
797Drugs
8 Major 618 Moderate 171 Minor

Ingredients driving the most interactions

Caffeine Anhydrous 655
Sodium 205
L-Taurine 173
Potassium 62
Choline 16

Individual Drug Interactions

The ingredients in Pre-Workout Blue Raspberry Ring Pop interact with 797 drugs. Click any drug to see the details.

5 of the 10 ingredients in Pre-Workout Blue Raspberry Ring Pop interact with drugs. Each result below shows which ingredient is responsible. Caffeine Anhydrous Sodium L-Taurine Potassium Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Pre-Workout Blue Raspberry Ring Pop with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Caffeine Anhydrous41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Anhydrous full monograph & all 41 interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

L-Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
L-Taurine full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pre-Workout Blue Raspberry Ring Pop, from the product label.

Ryse

See all Ryse products
Name
Ryse Up Sports Nutrition, LLC
Street Address
6644 All Stars Ave #140
City
Frisco
State
TX
ZipCode
75033
Phone Number
1-855-Ryseup1 (797-3871)
Web Address
www.Rysesupps.com
Pharmacist Counseling Corner

Pre-Workout Blue Raspberry Ring Pop by Ryse: Common Questions

Does Pre-Workout Blue Raspberry Ring Pop by Ryse interact with any medications?
Yes. Based on its ingredients, Pre-Workout Blue Raspberry Ring Pop has a known interaction with 797 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pre-Workout Blue Raspberry Ring Pop contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have a lot of sodium in it?
The product facts don't specify the exact sodium amount per serving, so you'd need to check the label. But sodium is listed as an active ingredient, which means it's present in a meaningful amount—enough to interact with blood pressure and heart medications. If you're watching sodium intake or take blood pressure meds, check the nutrition label and discuss it with your pharmacist.
Will this keep me awake at night?
Yes, possibly. This product contains both caffeine anhydrous and zumXR (extended-release caffeine), so you're getting a double dose of caffeine. Common side effects include insomnia, anxiety, and jitteriness. If you're sensitive to caffeine or take it late in the day, sleep disturbance is likely.
Is beta-alanine safe?
Beta-alanine is generally well tolerated in healthy adults, but it commonly causes a harmless tingling and flushing feeling on your skin that can last about an hour. The product facts note there isn't enough safety data for pregnancy or breastfeeding, so those groups should avoid it.
Can I take this if I'm pregnant or breastfeeding?
Caffeine is possibly safe in pregnancy but possibly unsafe at high doses, so limits matter—ask your doctor. Potassium, choline, L-taurine, and betaine are likely safe in pregnancy. Beta-alanine and Thinkamine lack safety data for pregnancy and breastfeeding, so avoid them unless your doctor advises otherwise. Talk with your doctor about your specific situation and the caffeine dose in this product.
What does L-taurine do in a pre-workout?
L-taurine supports muscle endurance and heart function. The data shows it's possibly effective for congestive heart failure and certain liver conditions, though its direct benefit for workout performance is not established in the facts we hold. It's generally well tolerated, though long-term safety at high supplement doses is still being studied.
Will this work better than other pre-workouts?
The product facts don't compare this to other brands. Caffeine is proven to boost alertness and athletic performance, and beta-alanine is possibly effective for endurance—those are the strongest claims. The other ingredients lack established evidence for sports performance in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pre-Workout Blue Raspberry Ring Pop label
Go deeper

The Full Monographs Behind Pre-Workout Blue Raspberry Ring Pop’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph →
Sources

Sources & How We Checked

Pre-Workout Blue Raspberry Ring Pop's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 345 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
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  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
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  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
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  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
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  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
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  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Potassium 12 references
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  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
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See these in context on the Potassium monograph →

Caffeine 236 references
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Taurine 21 references
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Betaine Anhydrous 11 references
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Choline 14 references
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Beta-alanine 13 references
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