Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Prima Una de Gato II Liquid Ingredients & Drug Interactions

by Allergy Research Group

Prima Una de Gato II Liquid label
See full label image
Liquid Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Prima Una de Gato II Liquid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Prima Una de Gato II Liquid is a dietary supplement by Allergy Research Group with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis and rheumatoid arthritis, inflammation, immune support.Based on those ingredients, 962 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cat's Claw bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Prima Una de Gato II Liquid by Allergy Research Group

Ask about any prescription or over-the-counter medication and we check it for interactions with Prima Una de Gato II Liquid by Allergy Research Group — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Prima Una de Gato II Liquid by Allergy Research Group

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 1 of its 2 active ingredients.

Prima Una de Gato II Liquid contains two active ingredients: cat's claw bark extract and concentrated minerals. Cat's claw — a vine native to the Amazon — has been used traditionally in herbal medicine for various conditions.

The liquid form also contains ethanol and distilled water as inactive ingredients.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Cat's claw extract for immune and inflammatory support.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Inflammatory bowel disease (IBD), Inflammation, Joint health.
  • The closest evidence on file: Cat's Claw is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD) (Natural Medicines).
  • Also on file: Cat's Claw is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis, Rheumatoid arthritis (RA).

The evidence we hold on cat's claw doesn't establish that it works for any of the conditions it's marketed for — allergic rhinitis, Alzheimer's disease, asthma, osteoporosis, cancer, and chronic fatigue syndrome all have insufficient reliable evidence to rate. That doesn't mean it doesn't work; it means the research backing it up isn't solid enough yet.

The evidence, ingredient by ingredient Cat's Claw

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cat's claw is generally well tolerated short-term in healthy adults, but we don't know much about long-term safety. The main caution comes from adverse effects noted in one clinical study of patients with advanced tumors: anemia occurred in 12%, and smaller numbers experienced blood cell changes, headache, fatigue, insomnia, and nerve damage — though because these patients had serious illness and no placebo group was used, we can't be sure cat's claw caused them.

A few case reports link cat's claw to kidney injury, though the link isn't certain. The safety data advises against using this product during pregnancy because of its historical use as an abortifacient and lack of safety information.

There isn't enough data on breastfeeding to know whether it's safe, so talk with your doctor or pharmacist about whether to use it if you're nursing.

Side effects, ingredient by ingredient Cat's Claw

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cat's Claw.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 963 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs, blood pressure medications or calcium channel blockers, drugs metabolized by the liver enzyme CYP3A4 (including some statins and antihistamines), immune-suppressing medications, or nirmatrelvir (Paxlovid). All of these have documented theoretical interactions with cat's claw.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for someone interested in cat's claw's traditional uses but willing to accept that strong evidence for its effectiveness isn't there yet. If you take any blood pressure medications, blood thinners, immune-suppressing drugs, or drugs metabolized by CYP3A4 — a huge category — you need to check with your doctor or pharmacist before starting it.

Don't use it if you're pregnant, and breastfeeding safety is unclear.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Prima Una de Gato II Liquid, straight from the product label.

Brand Allergy Research Group
Barcode (UPC) 713947750814
Net contents 30 mL; 1 fl. Oz.
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 258337
Product type Botanical With Nutrients
Supplement form Liquid
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Prima Una de Gato II Liquid by Allergy Research Group, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.05 mL
Maximum serving Sizes:
0.25 mL
Servings per container
120
UPC/BARCODE
713947750814
IngredientAmount% DV
concentrated Minerals0 NP--
Cat's Claw bark extract50 mg--

Other ingredients: Ethanol, distilled Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Cat's claw (Uncaria tomentosa) extract containing 3% total alkaloids. Minerals are added to the formula.

General Statements

Replaces #75080.

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 1 to 5 drops one to three times daily on an empty stomach, or as directed by a healthcare practitioner. Put 1 to 5 drops in a glass, then add 4 ounces of pure water and wait one minute before drinking. Shake well before each use.

Sensitive individuals may need to stay with 1 drop per day for an extended period of time, and increase very gradually.

Precautions

Keep out of reach of children.

Use under medical supervision. Herxheimer reaction may occur.

Not recommended for pregnant or nursing women or organ transplant recipients.

FDA Statement of Identity

Dietary Supplement

Formulation

Hypoallergenic

Storage

Keep in a cool, dry place, tightly capped.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Prima Una de Gato II Liquid by Allergy Research Group label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Prima Una de Gato II Liquid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Prima Una de Gato II Liquid by Allergy Research Group

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.05 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Concentrated Minerals

0 NP per serving

Cat's Claw bark extract

Interacts with
962 drugs
50 mg per serving

Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arth...

Cat's Claw bark extract monograph & interactions

Other (inactive) ingredients: Ethanol, Distilled Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Prima Una de Gato II Liquid by Allergy Research Group Drug Interactions

Want to check YOUR meds against Prima Una de Gato II Liquid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
962Drugs
962 Moderate

Ingredients driving the most interactions

Cat's Claw bark extract 962

Individual Drug Interactions

The ingredients in Prima Una de Gato II Liquid interact with 962 drugs. Click any drug to see the details.

1 of the 2 ingredients in Prima Una de Gato II Liquid interact with drugs. Each result below shows which ingredient is responsible. Cat's Claw bark extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Prima Una de Gato II Liquid with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cat's Claw bark extract6 drug types · 962 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Cat's claw contains rhynchophylline and isorhynchophylline. Animal research suggests that these alkaloids can inhibit platelet aggregation. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.
Cat's claw contains rhynchophylline. In vitro and animal research suggests that rhynchophylline can lower blood pressure. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Calcium Channel Blockers

Theoretically, taking cat's claw with calcium channel blockers might increase the risk of hypotension.
Cat's claw contains various alkaloids, including rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxiene. Animal research suggests that these alkaloids can lower blood pressure by acting as calcium channel blockers. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Cat's claw may affect the clearance of drugs metabolized by CYP3A4. In vitro research shows that cat's claw can inhibit CYP3A4 enzymes. In one case report, a patient taking cat's claw (at an unspecified dose) experienced increased serum levels of atazanavir, ritonavir, and saquinavir, all of which are CYP3A4 substrates. Levels returned to normal 15 days after discontinuation of the cat's claw supplement, suggesting inhibition of CYP3A4 by cat's claw. In contrast, animal research suggests that rhynchophylline, an alkaloid contained in cat's claw, induces CYP3A expression and accelerates the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, cat's claw might interfere with immunosuppressive therapy.
In human and laboratory research, cat's claw has been shown to have immunostimulating activity. It stimulates phagocytosis and increases respiratory cellular activity and the mobility of leukocytes. Theoretically, this could interfere with the activity of immunosuppressant medications.

Likelihood Possible Evidence D
Nirmatrelvir/Ritonavir (Paxlovid)

Theoretically, cat's claw may decrease the levels of nirmatrelvir.
Cat's claw contains rhynchophylline. Animal research suggests that this alkaloid induces CYP3A expression, thereby accelerating the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cat's Claw bark extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Prima Una de Gato II Liquid, from the product label.

Allergy Research Group

See all Allergy Research Group products
Name
Allergy Research Group
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800-545-9960
Web Address
www.allergyresearchgroup.com
Pharmacist Counseling Corner

Prima Una de Gato II Liquid by Allergy Research Group: Common Questions

Does Prima Una de Gato II Liquid by Allergy Research Group interact with any medications?
Yes. Based on its ingredients, Prima Una de Gato II Liquid has a known interaction with 962 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Prima Una de Gato II Liquid contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
No — the safety data advises against it. Cat's claw has a history of use as an abortifacient, and we don't have safety information for pregnancy. Talk with your doctor before using it.
Is cat's claw safe to take long-term?
We know it's generally well tolerated short-term, but long-term safety hasn't been well studied. If you're thinking about using it regularly, discuss that with your doctor or pharmacist.
What is cat's claw, and why is it in this product?
Cat's claw is a vine from the Amazon traditionally used in herbal medicine. This product contains its bark extract, though the evidence that it actually works for the conditions marketed — like allergies, asthma, or osteoporosis — isn't strong enough to rate yet.
Does this product have side effects?
In one study of patients with advanced cancer, anemia occurred in 12%, and smaller numbers had blood cell changes, headache, fatigue, insomnia, and nerve damage. A few case reports also link cat's claw to kidney injury. Because the study patients were very ill and had no placebo group, we can't be certain these were all from cat's claw itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Prima Una de Gato II Liquid is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Prima Una de Gato II Liquid label
Go deeper

The Full Monographs Behind Prima Una de Gato II Liquid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cat's Claw

Interacts with 962 drugs

Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arthritis symptoms, but the overall evidence...

Read the full Cat's Claw monograph →
Sources

Sources & How We Checked

Prima Una de Gato II Liquid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cat's Claw 16 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  3. Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
  4. Müller AC, Kanfer I. Potential pharmacokinetic interactions between antiretrovirals and medicinal plants used as complementary and African traditional medicines. Biopharm Drug Dispos. 2011;32(8):458-70. PubMed
  5. Sheng, Y., Bryngelsson, C., and Pero, R. W. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000;69(2):115-126. PubMed
  6. Lamm, S., Sheng, Y., and Pero, R. W. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine 2001;8(4):267-274.
  7. Sheng, Y., Li, L., Holmgren, K., and Pero, R. W. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001;8(4):275-282.
  8. Chen, C. X., Jin, R. M., Li, Y. K., Zhong, J., Yue, L., Chen, S. C., and Zhou, J. Y. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1992;13(2):126-130.
  9. Flythe, J. E., Rueda, J. F., Riscoe, M. K., and Watnick, S. Silicate nephrolithiasis after ingestion of supplements containing silica dioxide. Am.J.Kidney Dis. 2009;54(1):127-130. PubMed
  10. Zhou, J. and Zhou, S. Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity. J.Ethnopharmacol. 10-28-2010;132(1):15-27. PubMed
  11. Zhou, J. Y. and Zhou, S. W. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia 2012;83(4):617-626. PubMed
  12. Hemingway, S. R. and Phillipson, J. D. Proceedings: Alkaloids from S. American species of Uncaria (Rubiaceae). J.Pharm.Pharmacol. 1974;26 Suppl:113P.
  13. Hilepo, J. N., Bellucci, A. G., and Mossey, R. T. Acute renal failure caused by 'cat's claw' herbal remedy in a patient with systemic lupus erythematosus. Nephron 1997;77(3):361. PubMed
  14. De Paula LCL, Fonseca F, Perazzo F, et al. Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. J Altern Complement Med. 2015;21(1):22-30.
  15. Portalatin G, Shettigar S, Carrion-Rodriguez A, et al. Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis. Case Rep Nephrol Dial 2022;12(3):219-225.
  16. Lei S, Guo A, Lu J, et al. Activation of PXR causes drug interactions with Paxlovid in transgenic mice. Acta Pharm Sin B 2023;13(11):4502-4510. PubMed

See these in context on the Cat's Claw monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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