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Dietary supplement

Pro-Rite Ingredients & Drug Interactions

by Carlson

Pro-Rite label
See full label image
Capsule Category: Amino Acid/protein
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pro-Rite against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Pro-Rite is a dietary supplement by Carlson with 2 active ingredients. Its ingredients are commonly taken for joint and connective tissue support, skin health and wound healing, collagen production.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pro-Rite by Carlson

Ask about any prescription or over-the-counter medication and we check it for interactions with Pro-Rite by Carlson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pro-Rite by Carlson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Pro-Rite contains 2 active ingredients: L-proline and L-lysine. Both are amino acids (the building blocks your body uses to make protein and other compounds).

The product also contains hypromellose, an inactive ingredient used as a capsule material. L-proline is a component of collagen, the structural protein in skin, bone, and connective tissue.

L-lysine is an essential amino acid your body cannot make on its own — you get it from food sources like meat, cheese, and legumes.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: healthy collagen formation and connective tissue support.
  • We looked for evidence on: Fractures, Osteoporosis, Osteopenia, Wound healing, Pressure ulcers, Joint health — and 3 related terms.
  • The closest evidence on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Pressure ulcers (Natural Medicines).
  • Also on file: Proline is rated "Insufficient Reliable Evidence To Rate" for Osteoporosis, Fractures, Wound healing, Osteopenia.

The evidence behind L-proline for athletic performance, osteoporosis, fractures, wound healing, and osteopenia is insufficient — we don't have reliable data to say whether it works for these uses. L-lysine is possibly effective for cold sores (herpes labialis).

For child growth, pressure ulcers, and diabetic foot ulcers, the evidence is insufficient to rate its effectiveness.

The evidence, ingredient by ingredient Proline Lysine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-lysine is generally well tolerated at typical doses, though high amounts may cause stomach upset (abdominal pain, diarrhea, indigestion). Long-term safety of high-dose supplements hasn't been well studied.

A rare case report linked oral lysine to a kidney inflammation that progressed to chronic kidney failure, but this is not established as a common risk. L-proline from food is considered low-risk, but supplement safety at higher doses hasn't been thoroughly studied.

There isn't enough reliable data on supplemental doses of either ingredient during pregnancy or breastfeeding — talk with your doctor or pharmacist for personalized advice before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Proline Lysine

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lysine.
  • The most serious interaction on file is rated Minor.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take a 5-HT4 agonist (a drug that stimulates serotonin receptor 4, used for stomach motility) — L-lysine may reduce its effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

If you're taking a 5-HT4 agonist, check with us before starting Pro-Rite — L-lysine may reduce how well that drug works. Otherwise, both ingredients are generally well tolerated at typical doses.

Pregnancy, breastfeeding, or kidney concerns? Talk to your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pro-Rite, straight from the product label.

Brand Carlson
Barcode (UPC) 088395687105
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 337616
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pro-Rite by Carlson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
088395687105
IngredientAmount% DV
L-Proline500 mg--
L-Lysine500 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Pro-Rite combines free-form L-proline and L-lysine, essential components for healthy collagen formation.

Free-form L-Proline & L-Lysine

Formulation

Collagen is a structural component that helps form the connective tissues for healthy ligaments, blood vessels, and bones. Natural color variation may occur. Potency & quality guaranteed An FDA regulated facility

Gluten-free No artificial preservatives

Cardiovascular health Joint support Collagen formation

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place after opening.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults: take two capsules daily at mealtime.

Precautions

Warning: Consult a physician before taking if pregnant or lactating, taking medication or have a medical condition.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pro-Rite by Carlson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pro-Rite label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pro-Rite by Carlson

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Proline

No known
interactions
500 mg per serving

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of...

L-Proline monograph & interactions

L-Lysine

Interacts with
1 drug
500 mg per serving Form: Lysine Monohydrochloride

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...

L-Lysine monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pro-Rite by Carlson Drug Interactions

Want to check YOUR meds against Pro-Rite?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Minor

Ingredients driving the most interactions

L-Lysine 1

Individual Drug Interactions

The ingredients in Pro-Rite interact with 1 drug. Click any drug to see the details.

1 of the 2 ingredients in Pro-Rite interact with drugs. Each result below shows which ingredient is responsible. L-Lysine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pro-Rite with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Lysine1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pro-Rite, from the product label.

Carlson

See all Carlson products
Name
Carlson Div. of J.R. Carlson Laboratories, Inc.
City
Lincolnshire
State
IL
ZipCode
60069
Phone Number
888-234-5656
Web Address
carsonlabs.com
Pharmacist Counseling Corner

Pro-Rite by Carlson: Common Questions

Does Pro-Rite by Carlson interact with any medications?
Yes. Based on its ingredients, Pro-Rite has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pro-Rite contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does L-lysine really help cold sores?
L-lysine is possibly effective for cold sores (herpes labialis) based on available evidence. That's the strongest evidence claim we have for either ingredient in this product, though more research would help clarify how well it works.
What are the most common side effects?
L-lysine may cause abdominal pain, diarrhea, or indigestion — especially at high doses. L-proline has no reported adverse effects in the data we hold. Both are generally well tolerated at typical supplement doses.
Is it safe to take while pregnant?
There isn't enough reliable data on supplement use of either ingredient during pregnancy. Lysine from food is fine, but check with your doctor or pharmacist before taking this supplement if you're pregnant.
What is L-proline used for in this product?
L-proline is a component of collagen, which makes up skin, bone, and connective tissue. The product markets it for bone and joint support, but reliable evidence that it works for osteoporosis, fractures, wound healing, or athletic performance is insufficient at this time.
Can I take this if I have kidney problems?
There is one case report of oral L-lysine linked to kidney inflammation that progressed to chronic kidney failure — though this is rare and not a proven common risk. If you have kidney concerns, talk to your pharmacist or doctor before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pro-Rite label
Go deeper

The Full Monographs Behind Pro-Rite’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proline

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of collagen, but strong human evidence that...

Read the full Proline monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph →
Sources

Sources & How We Checked

Pro-Rite's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proline 4 references
  1. Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
  2. Gracia-Marco L, Bel-Serrat S, Cuenca-Garcia M, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49(6):1041-1052. PubMed
  3. Jamdar J, Rao B, Netke S, et al. Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid, lysine, and proline. J Altern Complement Med. 2004;10(6):915-6.
  4. Mehl AA, Damião AO, Viana SD, Andretta CP. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care 2021;30(1):26-31. PubMed

See these in context on the Proline monograph →

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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