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Dietary supplement

Probio-Daily Ingredients & Drug Interactions

by Higher Nature

Probio-Daily label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probio-Daily against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probio-Daily is a dietary supplement by Higher Nature with 2 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus coagulans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probio-Daily by Higher Nature

Ask about any prescription or over-the-counter medication and we check it for interactions with Probio-Daily by Higher Nature — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probio-Daily by Higher Nature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Probio-Daily contains 2 active ingredients. The first is Bacillus coagulans, a spore-forming probiotic bacterium — basically a beneficial microorganism that supports digestive health.

The second is fructo-oligosaccharides (FOS), a type of fiber that acts as a prebiotic, meaning it feeds the good bacteria already in your gut. Together, they're designed to promote a healthier gut environment.

The product also contains several inactive ingredients (binders and fillers) including hydroxypropyl methylcellulose, magnesium stearate, vanilla flavor, and glycerine.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and gut health support.
  • We looked for evidence on: Constipation, Irritable bowel syndrome (IBS), Dyspepsia, Flatulence, Antibiotic-associated diarrhea, Clostridioides difficile infection — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Fructo-oligosaccharides (fos) is rated "Insufficient Reliable Evidence To Rate" for Constipation, Travelers' diarrhea.

For constipation and irritable bowel syndrome (IBS), Bacillus coagulans is possibly effective based on the evidence we have — it may help, but the research isn't conclusive. For antibiotic-associated diarrhea, athletic performance, cancer support, and nonalcoholic fatty liver disease (NAFLD), there isn't enough reliable evidence yet to say whether B. coagulans works.

For FOS, the evidence on constipation, diabetes, travelers' diarrhea, and high cholesterol falls short of what we need to make a solid claim.

The evidence, ingredient by ingredient Bacillus Coagulans Fructo-oligosaccharides (fos)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, but safety data varies across products and is limited overall — talk to your doctor before using. There's a theoretical risk that live probiotics could cause serious infection (bacteremia or sepsis) in people with weakened immune systems, central lines, or severe illness, though this is rare in otherwise healthy people with intact immunity.

FOS is generally well tolerated at food amounts but can cause gas, bloating, flatulence, and abdominal pain, especially at higher doses — research shows that doses under 10 grams daily are usually mild, though individual responses vary. Neither ingredient has enough pregnancy and lactation data on file, so talk to your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Bacillus Coagulans Fructo-oligosaccharides (fos)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotics are the main concern — they can reduce how well Bacillus coagulans works by killing the live organisms in the product. Time them at least a few hours apart.

Check your exact medications with the search tool on this page, and talk to your doctor or pharmacist before combining this supplement with any prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Probio-Daily may be worth considering if you're dealing with constipation or IBS and want a probiotic boost. If you take antibiotics, time them several hours apart from this product so the good bacteria survive.

Check your full medication list — especially antibiotics — with your doctor or pharmacist before starting, and mention any immune system concerns or recent severe illness.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probio-Daily, straight from the product label.

Brand Higher Nature
Barcode (UPC) 5031013107061
Net contents 6 Tablet(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 41422
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probio-Daily by Higher Nature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
UPC/BARCODE
5031013107061
IngredientAmount% DV
Bacillus coagulans150000000 {Unit(s)}--
Fructo-Oligosaccharides100 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Magnesium Stearate, Vanilla Flavour, Glycerine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

TRIAL SIZE

This product is not tested on animals.

Charitable organisations policy: supplements regularly donated

This bottle has a UV filter.

Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Formulation

DAIRY FREE

DOES NOT CONTAIN: soya, wheat, gluten, yeast, lactose, dairy products, artificial preservatives, colours or flavourings.

Suitable for vegetarians and vegans.

VEGAN

Storage

Ensure lid is tight and store in a cool, dry, steam-free environment as damp conditions can affect the product quality.

No refrigeration required if stored at room temperature. Exposure to excessive heat should be avoided.

Bacillus coagulans, unlike many probiotics, survives stomach acids well because it is in 'spore' form, and is ideal for travel because it does not need to be refrigerated.

General

PRD006 102 PRD-046-04

Formula

*At the time of manufacture each tablet contains 150 million Bacillus coagulans.

Hypo-allergenic formula.

Bacillus coagulans probiotic formula

Contains sulphur dioxide (at maximum 13.5 parts per million).

Seals/Symbols

Jar {Recycle} 1 PET Lid {Recycle} 5 PP

FDA Statement of Identity

FOOD SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take 1 tablet up to 3 times a day (children over 8 years, 1-2 tablets a day), with meals, or as your health professional advises. Do not exceed recommended daily intake.

Suggested uses: - especially during and after taking antibiotics.

Precautions

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probio-Daily by Higher Nature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probio-Daily label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probio-Daily by Higher Nature

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bacillus coagulans

Interacts with
182 drugs
150000000 {Unit(s)} per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Bacillus coagulans monograph & interactions

Fructo-Oligosaccharides

No known
interactions
100 mg per serving

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are gener...

Fructo-Oligosaccharides monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Magnesium Stearate, Vanilla Flavour, Glycerine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probio-Daily by Higher Nature Drug Interactions

Want to check YOUR meds against Probio-Daily?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus coagulans 182

Individual Drug Interactions

The ingredients in Probio-Daily interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Probio-Daily interact with drugs. Each result below shows which ingredient is responsible. Bacillus coagulans

Each ingredient & the kinds of drugs it affects

For each ingredient in Probio-Daily with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probio-Daily, from the product label.

Higher Nature

See all Higher Nature products
Name
Higher Nature
City
Burwash Common
State
East Sussex
ZipCode
TN19 7LX
Web Address
www.highernature.com
Pharmacist Counseling Corner

Probio-Daily by Higher Nature: Common Questions

Does Probio-Daily by Higher Nature interact with any medications?
Yes. Based on its ingredients, Probio-Daily has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probio-Daily contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my constipation?
Bacillus coagulans in this product is possibly effective for constipation, meaning it may help based on available evidence, but it's not a sure thing. How well it works varies from person to person. If you don't see improvement after a couple of weeks, let your doctor know.
Can I take this while I'm on an antibiotic?
Yes, but timing matters. Antibiotics can kill the live bacteria in this product and make it less effective. Separate them by a few hours — your pharmacist can suggest the best schedule for your specific antibiotic.
What's FOS and why is it in here?
FOS (fructo-oligosaccharides) is a type of fiber that acts as food for the good bacteria already in your gut, helping them thrive. It's designed to work alongside the Bacillus coagulans probiotic.
Does this have a lot of fillers?
The product contains a few inactive ingredients — hydroxypropyl methylcellulose, magnesium stearate, vanilla flavor, and glycerine — which are standard binders and flavorings used in tablets. They're present in modest amounts.
Could this cause side effects?
Bacillus coagulans is generally well tolerated, though reports of infection are possible in people with very weak immune systems. FOS commonly causes gas, bloating, or mild abdominal discomfort, especially at higher doses, though studies show this is usually mild below 10 grams a day.
Is it safe to use if I'm pregnant or breastfeeding?
There isn't enough data on file about either ingredient during pregnancy or lactation to know either way. Talk to your doctor or pharmacist for personalized advice before using it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probio-Daily is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probio-Daily label
Go deeper

The Full Monographs Behind Probio-Daily’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph → Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph →
Sources

Sources & How We Checked

Probio-Daily's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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