Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Probiotic Ingredients & Drug Interactions

by Nutrition Essentials

Probiotic label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic is a dietary supplement by Nutrition Essentials with 3 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uni-BactCF-15. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic by Nutrition Essentials

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic by Nutrition Essentials — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic by Nutrition Essentials

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Super Probiotic Blend” is a proprietary blend — the label gives one combined amount (75 mg) without saying how much of each component you get.

This tablet or pill contains 3 active ingredients. Lactase is an enzyme that helps break down lactose, the natural sugar in dairy products.

Bacillus coagulans (listed here as Uni-BactCF-15) is a probiotic — a live microorganism intended to support gut health. The Super Probiotic Blend is a mix of additional beneficial microorganisms.

The product also contains inactive ingredients (microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silicon dioxide, vegetable magnesium stearate, and hydroxypropyl methylcellulose) that help hold the tablet together and aid in its release.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive health support and healthy bacterial balance.
  • We looked for evidence on: Constipation, Flatulence, Irritable bowel syndrome (IBS), Lactose intolerance, Dyspepsia, bloating — and 2 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation, Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Flatulence.

Lactase is effective for lactose intolerance — the inability to digest lactose in milk and dairy. Evidence is insufficient to rate it for colic or premature infant care.

Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome (IBS), though evidence remains preliminary. For antibiotic-associated diarrhea, athletic performance, cancer, and nonalcoholic fatty liver disease, the evidence isn't established in the data we hold.

The evidence, ingredient by ingredient Lactase Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase is generally well tolerated when used as directed, though a rare case of allergic reactions has been reported in someone exposed to powdered lactase in a workplace setting. Bacillus coagulans is generally well tolerated in healthy adults, but product quality and safety data vary.

Because it contains live organisms, there is theoretical concern it could cause infection in severely ill or immunocompromised patients, including those with central lines or indwelling catheters, though such reports remain uncommon in people with intact immune systems. For pregnancy and lactation, lactase is rated likely safe; for Bacillus coagulans, safety data is limited.

Talk with your doctor or pharmacist before regular use during pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Lactase Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before combining this product with antibiotic drugs — taking them at the same time may reduce how well the probiotic works. Separate the doses according to your healthcare provider's guidance.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with lactose intolerance and possibly with constipation or IBS symptoms. If you take antibiotics, you'll need to time them separately from this probiotic — ask your pharmacist for the best schedule.

Anyone with a weakened immune system, central line, or severe illness should check with their doctor first. Before starting, confirm with your own doctor or pharmacist that it fits your health and medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic, straight from the product label.

Brand Nutrition Essentials
Barcode (UPC) X000SA9DUB
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 240438
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic by Nutrition Essentials, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
UPC/BARCODE
X000SA9DUB
IngredientAmount% DV
Lactase----
Nutri-Fructo B-88500 mg--
Super Probiotic Blend75 mg--
Uni-BactCF-150 NP--

Other ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Croscarmellose Sodium, Silicon Dioxide, Vegetable Magnesium Stearate, Hydroxypropyl Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: For adults only. Take two (2) tablets per day on an empty stomach. Do not exceed 2 tablets per day.

Precautions

Caution: Women who are pregnant or lactating and anyone taking medications or other dietary supplements should consult a health care professional before using any nutritional product.

If any adverse reactions occur, discontinue use and consult a health care professional.

Not for use by children under the age of 18. Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Digestive health support formula Supports healthy digestive balance Helps replenish healthy bacteria Promotes immune system health

Seals/Symbols

GMP Followed

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Uni-Bact CF-15 is a trademark of Union Biotech Sciences Nutri-Fructo B-88 is a trademark of Avexyl Pharma, LLC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic by Nutrition Essentials label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic by Nutrition Essentials

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Nutri-Fructo B-88

500 mg per serving Form: Fructooligosaccharide

Super Probiotic Blend

75 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Croscarmellose Sodium, Silicon Dioxide, Vegetable Magnesium Stearate, Hydroxypropyl Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic by Nutrition Essentials Drug Interactions

Want to check YOUR meds against Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Uni-BactCF-15 182

Individual Drug Interactions

The ingredients in Probiotic interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Probiotic interact with drugs. Each result below shows which ingredient is responsible. Uni-BactCF-15

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Uni-BactCF-151 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Uni-BactCF-15 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic, from the product label.

Nutrition Essentials

See all Nutrition Essentials products
Name
Boost Marketing Group LLC
Street Address
PO Box 998
City
Ada
State
MI
ZipCode
49301
Phone Number
616-421-3093
Pharmacist Counseling Corner

Probiotic by Nutrition Essentials: Common Questions

Does Probiotic by Nutrition Essentials interact with any medications?
Yes. Based on its ingredients, Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does lactase help if I'm lactose intolerant?
Yes, lactase is effective for lactose intolerance. It's an enzyme that breaks down lactose so you can digest dairy more easily.
What is Bacillus coagulans and what's it for?
It's a probiotic — a live microorganism that may help with constipation and irritable bowel syndrome. The evidence is preliminary, but it's possibly effective for those conditions.
Can I take this while I'm on antibiotics?
You shouldn't take them at the same time. Antibiotics can kill the live organisms in this product, making it less effective. Ask your pharmacist to help you space them out — usually several hours apart.
Is this safe during pregnancy?
Lactase is rated likely safe in pregnancy. For the Bacillus coagulans, safety data is limited, so talk with your doctor or pharmacist first to get personalized advice.
What are the inactive ingredients, and is this free of fillers?
The inactive ingredients are microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silicon dioxide, vegetable magnesium stearate, and hydroxypropyl methylcellulose. These help the tablet hold together and release properly — they're standard in tablet formulations.
Are there any reported side effects?
Lactase is generally well tolerated; a rare allergic reaction in a factory worker exposed to powdered lactase has been reported. Bacillus coagulans is generally well tolerated in healthy people, though live microorganisms carry a theoretical risk of infection in severely ill or immunocompromised patients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic label
Go deeper

The Full Monographs Behind Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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