Probiotic GX Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Probiotic GX against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Probiotic GX is a dietary supplement by Nature's Bounty with 4 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Probiotic GX by Nature's Bounty
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Probiotic GX contains four active ingredients: amylase, protease, lipase, and Lactobacillus plantarum Lp299v. The first three are digestive enzymes that help break down different types of food—amylase works on starches, protease on proteins, and lipase on fats.
Lactobacillus plantarum Lp299v is a probiotic bacterial strain meant to support gut health. The capsule also contains inactive ingredients including vegetable cellulose, gelatin, and maltodextrin.
Does it work?
Not established
The evidence for lipase and protease in supporting digestion or bowel health is insufficient to establish their effectiveness—we don't have reliable data showing they work for their intended purposes. We hold no effectiveness data for amylase or Lactobacillus plantarum Lp299v in our files.
If you're considering this product for a specific digestive concern, talk with your doctor or pharmacist about whether the evidence supports it for your situation.
How safe is it?
Well-documented data
Protease and lipase are generally well tolerated in adults, but both can occasionally cause digestive upset. Protease, in rare cases, has been linked to allergic reactions—occupational exposure to airborne protease enzymes has rarely triggered allergic rhinitis or asthma.
Lipase has not been thoroughly studied for safety, and in premature infants receiving a recombinant form added to formula or breast milk, gastrointestinal side effects and a slightly higher rate of necrotizing enterocolitis (a serious bowel condition) were reported—though this product is not intended for infants. For pregnancy, the safety data on protease advises against use unless prescribed.
Lipase has little safety data in pregnancy and should be used only if your doctor recommends it. During breastfeeding, protease is not recommended without medical guidance, and lipase safety has not been well studied.
We hold no pregnancy or breastfeeding safety data for amylase or the probiotic strain. If you are pregnant, planning pregnancy, or breastfeeding, check with your doctor or pharmacist before taking this product.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, we cannot verify amylase or Lactobacillus plantarum Lp299v for drug interactions, so check with your doctor or pharmacist if you take any prescription medications.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
Probiotic GX may appeal to someone looking for enzyme and probiotic support for digestion, though the evidence for whether it works is not yet established in our data. If you have a serious digestive condition or are pregnant or breastfeeding, talk with your doctor or pharmacist first—some ingredients have limited safety data in those situations.
No interactions are documented for the ingredients we checked, but run your exact medications through our tool to be sure.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Probiotic GX, straight from the product label.
| Brand | Nature's Bounty |
|---|---|
| Barcode (UPC) | 074312552717 |
| Net contents | 25 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2021 |
| DSLD ID | 242572 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Probiotic GX by Nature's Bounty, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Enzyme Blend | 350 mg | -- |
| Lactobacillus plantarum Lp299v | 30 mg | -- |
Other ingredients: Vegetable Cellulose, Gelatin, Maltodextrin, Contains less than 2% of
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Nearly 50 years of trusted quality At Nature’s Bounty, we are committed to your health. For nearly 50 years we have been making trusted products, backed by science, and made with only the purest ingredients...guaranteed. So you can get the most out of life every day.
Nutrition Questions or Comments? Call 1-800-433-2990 Mon. - Sat. 9 AM - 7 PM ET Sign Up for News and Offers at NaturesBounty.com
Patent pending strain studied by gastroenterologists
Formulation
Guaranteed Quality Laboratory Tested
Non-GMO, no artificial color, no artificial flavor, no artificial sweetener, no sugar, no starch, no milk, no lactose, no yeast, no fish. Sodium free.
Made In The USA with select ingredients from around the world
Gas and bloating formula
Advanced support for gas & bloating to help with abdominal discomfort. Digestive health
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
Copyright 2020 Nature’s Bounty, Inc.
Lp299v and Probi Digestis are registered trademarks of Probi
Formula
20 Billion live cultures
20 billion active cultures per serving
Patent Pending Lp299v Strain
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: For adults, take one (1) capsule daily, with or without a meal.
Precautions
Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Do not use if seal under cap is broken or missing.
Contains wheat and soy ingredients.
Storage
Guaranteed quality and CFU through expiration when continuously stored in the original packaging as directed. Store in a cool, dry place away from direct sunlight.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Probiotic GX by Nature's Bounty label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Probiotic GX by Nature's Bounty
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Vegetable Cellulose, Gelatin, Maltodextrin, Contains less than 2% of. These complete the product’s ingredient list but are not active constituents.
Probiotic GX by Nature's Bounty Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Probiotic GX. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Probiotic GX, from the product label.
Nature's Bounty
See all Nature's Bounty products- Name
- Nature's Bounty, Inc.
- City
- Bohemia
- State
- NY
- ZipCode
- 11716
- Phone Number
- 1-800-433-2990
- Web Address
- www.NaturesBounty.com
Probiotic GX by Nature's Bounty: Common Questions
Does Probiotic GX by Nature's Bounty interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does each enzyme in this product do?
Can I take this if I'm pregnant?
Can I take this while breastfeeding?
What side effects might I have?
What is Lactobacillus plantarum Lp299v?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Probiotic GX is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Probiotic GX’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
Probiotic GX's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC