Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Elderberry Sambucus 630 mg Ingredients & Drug Interactions

by Nature's Bounty

Elderberry Sambucus 630 mg label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Elderberry Sambucus 630 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Elderberry Sambucus 630 mg is a dietary supplement by Nature's Bounty with 1 active ingredient. Its ingredients are commonly taken for colds, flu (influenza), other respiratory infections.Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Elderberry Juice Concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Elderberry Sambucus 630 mg by Nature's Bounty

Ask about any prescription or over-the-counter medication and we check it for interactions with Elderberry Sambucus 630 mg by Nature's Bounty — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Elderberry Sambucus 630 mg by Nature's Bounty

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: elderberry juice concentrate at 630 mg per softgel. Elderberry is made from the fruit of the elder tree and is traditionally used to support respiratory and immune health, though the evidence for specific conditions remains limited.

The capsule also contains several inactive ingredients — soybean oil, maltodextrin, gelatin, glycerin, soy lecithin, and natural caramel — which serve as the carrier, binder, and shell but play no active role in the supplement.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: immune support and respiratory health.
  • We looked for evidence on: Upper respiratory tract infection (URTI), Lower respiratory tract infections, Respiratory tract infections, Rhinosinusitis, Influenza, Common cold — and 1 related terms.
  • The closest evidence on file: Elderberry is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections (Natural Medicines).
  • Also on file: Elderberry is rated "Insufficient Reliable Evidence To Rate" for Rhinosinusitis, Upper respiratory tract infection (URTI), Lower respiratory tract infections.

The evidence we hold doesn't establish that elderberry relieves hay fever, supports heart health, eases chronic fatigue, helps COPD, sharpens thinking, or prevents respiratory infections. All six conditions listed in our data show insufficient reliable evidence to rate elderberry's effectiveness.

That doesn't mean it doesn't work — it means large, rigorous trials haven't been completed. If you're considering elderberry for one of these reasons, talk with your pharmacist or doctor about what the current research really shows.

The evidence, ingredient by ingredient Elderberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Properly prepared elderberry products — like this juice concentrate — are generally well tolerated. The main risk comes from raw or unripe berries, seeds, leaves, or bark, which can contain toxins that cause nausea, vomiting, diarrhea, weakness, dizziness, or numbness.

Cooking eliminates these toxins, and commercial extracts like this one are safe from that standpoint. One case report documented liver injury in a woman who took elderberry for years while also managing an autoimmune disease.

Avoid elderberry if you're pregnant or breastfeeding, since there isn't enough safety data in those situations. If you have an autoimmune or liver condition, check with your pharmacist before starting.

Side effects, ingredient by ingredient Elderberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Elderberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on immunosuppressants (drugs that weaken your immune system after transplant or for severe autoimmune conditions) — elderberry may interfere with how well they work. Also check if you take pazopanib (Votrient), a cancer drug, as a case of serious liver injury has been reported.

Use the medication search tool above to verify your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Elderberry Sambucus may be worth trying if you're looking for general immune or respiratory support and have no major health conditions or medications — but the evidence for specific benefits is thin. Stay away from it if you take immunosuppressants or pazopanib, and avoid it during pregnancy or breastfeeding.

Always run your exact medications through the checker on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Elderberry Sambucus 630 mg, straight from the product label.

Brand Nature's Bounty
Barcode (UPC) 074312009761
Net contents 120 Rapid Release Softgel(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 308196
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Elderberry Sambucus 630 mg by Nature's Bounty, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
40
UPC/BARCODE
074312009761
IngredientAmount% DV
Elderberry Juice Concentrate630 mg--

Other ingredients: Soybean Oil, Maltodextrin, Gelatin, Glycerin, Soy Lecithin, natural Caramel

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

50 years of trusted quality At Nature's Bounty, we are committed to your health. For 50 years we have been making trusted products, backed by science, and made with only the purest ingredients...guaranteed. So you can get the most out of life every day.

Nutrition questions or comments? Call 1-800-433-2990 Mon. - Sat. 9AM - 7 PM ET Sign up for news and offers at NaturesBounty.com #1 herbal supplement brand Source: IRI Total US-Multi Outlet: Latest 52 weeks ending 12/27/2020.

Formulation

Guaranteed quality Laboratory tested

Non-GMO, no artificial flavor, no artificial sweetener, no sugar, no starch, no milk, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

Made in the USA with select ingredients from around the world

Formula

Elderberry Sambucus 630 mg per serving Contains plant-based antioxidants

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take three (3) softgels daily, preferably with a meal.

Precautions

Contains soy ingredients.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

Brand IP Statement(s)

Copyright 2021 Nature's Bounty, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Elderberry Sambucus 630 mg by Nature's Bounty label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Elderberry Sambucus 630 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Elderberry Sambucus 630 mg by Nature's Bounty

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container40 Amounts shown are per serving.

Elderberry Juice Concentrate

Interacts with
121 drugs
630 mg per serving Form: Sambucus nigra

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Elderberry Juice Concentrate monograph & interactions

Other (inactive) ingredients: Soybean Oil, Maltodextrin, Gelatin, Glycerin, Soy Lecithin, Natural Caramel. These complete the product’s ingredient list but are not active constituents.

Interaction report

Elderberry Sambucus 630 mg by Nature's Bounty Drug Interactions

Want to check YOUR meds against Elderberry Sambucus 630 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Elderberry Juice Concentrate 121

Individual Drug Interactions

The ingredients in Elderberry Sambucus 630 mg interact with 121 drugs. Click any drug to see the details.

1 of the 1 ingredient in Elderberry Sambucus 630 mg interact with drugs. Each result below shows which ingredient is responsible. Elderberry Juice Concentrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Elderberry Sambucus 630 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Elderberry Juice Concentrate2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
Elderberry Juice Concentrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Elderberry Sambucus 630 mg, from the product label.

Nature's Bounty

See all Nature's Bounty products
Name
Nature's Bounty (NY), Inc.
City
Bohemia
State
NY
ZipCode
11716
Phone Number
1-800-433-2990
Web Address
NaturesBounty.com
Pharmacist Counseling Corner

Elderberry Sambucus 630 mg by Nature's Bounty: Common Questions

Does Elderberry Sambucus 630 mg by Nature's Bounty interact with any medications?
Yes. Based on its ingredients, Elderberry Sambucus 630 mg has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Elderberry Sambucus 630 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
There isn't enough reliable safety information about elderberry in pregnancy or breastfeeding, so the safety data advises against it. Talk with your doctor or pharmacist for personalized advice based on your situation.
What side effects might I notice?
When prepared properly (like this juice concentrate), elderberry extracts are generally well tolerated with few side effects. Nausea and vomiting are rare and usually linked to raw or unripe berries or other plant parts, not quality commercial products. One case tied nausea and vomiting to an elderberry-and-echinacea combo product, though it's unclear which ingredient caused it.
Does this actually work for colds or the flu?
The evidence we hold shows insufficient reliable data to say whether elderberry prevents or eases respiratory infections. That means large rigorous studies haven't been done yet, not that it doesn't help — just that we can't confirm it from the research available.
Is this safe if I have liver problems?
A case report documented liver injury in a woman who took elderberry for years with an underlying autoimmune disease. If you have liver disease or an autoimmune condition, talk with your pharmacist before starting, since elderberry may not be the right choice for you.
What's the difference between this and raw elderberries?
Raw or unripe elderberries, seeds, and leaves contain toxins that can cause nausea, vomiting, severe diarrhea, and other symptoms. This product is a prepared juice concentrate from ripe fruit, which eliminates those toxins through processing, making it safe — unlike eating raw berries straight off the tree.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Elderberry Sambucus 630 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Elderberry Sambucus 630 mg label
Go deeper

The Full Monographs Behind Elderberry Sambucus 630 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph →
Sources

Sources & How We Checked

Elderberry Sambucus 630 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Elderberry 6 references
  1. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
  2. Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
  3. European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
  4. Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
  5. Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
  6. Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed

See these in context on the Elderberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team