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Dietary supplement

Pumpkin Seed Extract Ingredients & Drug Interactions

by BulkSupplements.com

Pumpkin Seed Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pumpkin Seed Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pumpkin Seed Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pumpkin seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pumpkin Seed Extract by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Pumpkin Seed Extract by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pumpkin Seed Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pumpkin seed extract. It's a concentrated form of compounds from pumpkin seeds.

There are no other active ingredients in this formulation.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Pumpkin's overall clinical evidence instead.

Moderate

Some clinical evidence supports Pumpkin for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Benign prostatic hyperplasia (BPH) — rated "Possibly Effective" (Natural Medicines).

The evidence for pumpkin seed extract is mixed. It's rated Possibly Effective for benign prostatic hyperplasia (BPH) — the non-cancerous enlargement of the prostate gland that can affect urination in men.

For other uses — androgenic alopecia (male-pattern hair loss), interstitial cystitis (bladder pain), intestinal parasites, and urinary tract infections — there isn't enough reliable evidence yet to rate whether it works.

The evidence, ingredient by ingredient Pumpkin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pumpkin as a food is generally well tolerated. The concentrated seed supplements in this product are also generally well tolerated in most adults, though the safety data on concentrated extracts is less robust than on whole pumpkin.

The most common side effects reported are mild: abdominal discomfort, diarrhea, nausea, and vomiting. Rarely, anaphylaxis (a severe allergic reaction) has been reported.

There are also rare case reports of transient hair loss and severe gastrointestinal upset linked to high levels of cucurbitacin, a compound found mainly in wild or bitter-tasting pumpkins — not typical in commercial extracts. For pregnancy, there isn't enough data to know whether concentrated pumpkin seed supplements are safe; talk with your doctor or pharmacist about whether it's right for you during pregnancy.

Similarly, safety during breastfeeding isn't well studied — discuss it with your healthcare provider if you're nursing.

Side effects, ingredient by ingredient Pumpkin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pumpkin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main medication to double-check before taking this product is lithium. Pumpkin seed extract may reduce how your body clears lithium, raising its levels — a Moderate-severity concern that could require a dose adjustment from your doctor or pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Pumpkin seed extract may help with benign prostatic hyperplasia, though the evidence for other uses isn't established yet. If you take lithium, you'll need to check with your doctor or pharmacist before starting — the supplement may affect how your body processes it.

For anyone else without that medication, it's generally well tolerated, but run through your full medication list to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pumpkin Seed Extract, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X0018KUMHX
Net contents 1 kg; 35.3 Oz(s)
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 252913
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pumpkin Seed Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
2000
UPC/BARCODE
X0018KUMHX
IngredientAmount% DV
Pumpkin seed extract500 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & Pure Bulk Supplements

Formulation

Color may vary

Free of: added sugar, soy, dairy, yeast, gluten, additives

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 500 mg (about 1/5 tsp) once daily, or as directed by a physician.

Storage

Store in a dry, cool place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pumpkin Seed Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pumpkin Seed Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pumpkin Seed Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container2000 Amounts shown are per serving.

Pumpkin seed extract

Interacts with
1 drug
500 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin seed extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pumpkin Seed Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Pumpkin Seed Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Pumpkin seed extract 1

Individual Drug Interactions

The ingredients in Pumpkin Seed Extract interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Pumpkin Seed Extract interact with drugs. Each result below shows which ingredient is responsible. Pumpkin seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pumpkin Seed Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pumpkin seed extract1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pumpkin Seed Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Pumpkin Seed Extract by BulkSupplements.com: Common Questions

Does Pumpkin Seed Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Pumpkin Seed Extract has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pumpkin Seed Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does pumpkin seed extract actually help with prostate problems?
It's rated Possibly Effective for benign prostatic hyperplasia — the non-cancerous enlargement of the prostate. That means there's some evidence it may help, but it's not conclusive. Talk with your doctor about whether it's a good fit for your situation.
What are the most common side effects?
Most people tolerate it well. The side effects that do show up are usually mild: abdominal discomfort, diarrhea, nausea, or vomiting. Serious reactions like anaphylaxis are rare.
Is it safe to take during pregnancy?
There isn't enough data on concentrated pumpkin seed supplements during pregnancy to say either way. Talk with your doctor or pharmacist for personalized advice.
Can I take this while breastfeeding?
Safety during breastfeeding hasn't been well studied. Discuss it with your doctor or pharmacist to see if it's the right choice for you.
What's cucurbitacin and should I worry about it?
Cucurbitacin is a compound found mainly in wild or bitter-tasting pumpkins — it can cause hair loss, severe nausea, and vomiting at high levels. Commercial pumpkin seed extracts like this one don't typically contain dangerous amounts, but if your extract tastes very bitter, avoid it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pumpkin Seed Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pumpkin Seed Extract label
Go deeper

The Full Monographs Behind Pumpkin Seed Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph →
Sources

Sources & How We Checked

Pumpkin Seed Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
  4. Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
  5. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed

See these in context on the Pumpkin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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