Pure Glycine 500 Milligrams Ingredients & Drug Interactions
by Montiff
What is this page for?
First and foremost: checking Pure Glycine 500 Milligrams against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pure Glycine 500 Milligrams is a dietary supplement by Montiff with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pure Glycine 500 Milligrams by Montiff
Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Glycine 500 Milligrams by Montiff — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pure Glycine 500 Milligrams by Montiff
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Montiff Pure Glycine contains one active ingredient: glycine, an amino acid your body produces naturally and uses in protein building and nervous system function. Each capsule delivers 500 milligrams.
The capsule itself is made from gelatin, microcrystalline cellulose (a plant-based filler), silicon dioxide, and stearic acid.
Does it work?
Moderate evidence
Glycine is possibly effective for schizophrenia, meaning some evidence supports its use. For other conditions listed—3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, attention deficit-hyperactivity disorder (ADHD), benign prostatic hyperplasia (BPH)—and cystic fibrosis, there isn't enough reliable evidence in our data to say whether it works.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, but long-term safety data are limited. Mild sedation has occurred rarely and resolves quickly if you stop taking it.
A small number of users have reported irritability, insomnia, fatigue, memory problems, headache, or sensory changes, though it's unclear whether glycine caused these. Digestive symptoms—soft stools, nausea, vomiting, stomach discomfort—have also been rare and resolve rapidly upon discontinuation.
Dry mouth has been reported but isn't clearly linked to glycine. Pregnancy and lactation safety data are not established, so the safety data advises against use in pregnancy and caution while breastfeeding.
Talk with your doctor or pharmacist about whether this product is right for you in these situations.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril) for schizophrenia, check with your doctor or pharmacist before starting this supplement. Glycine may reduce its effectiveness and worsen schizophrenia symptoms.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Montiff Pure Glycine may be worth considering if you're exploring amino acid support and are interested in evidence for schizophrenia—though effectiveness for other conditions listed hasn't been established in our data. If you take clozapine, you'll need to check with your doctor or pharmacist before starting.
Pregnant or breastfeeding? Discuss this product with your healthcare provider, since safety data aren't complete.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pure Glycine 500 Milligrams, straight from the product label.
| Brand | Montiff |
|---|---|
| Barcode (UPC) | 683268104811 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2015 |
| DSLD ID | 42027 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pure Glycine 500 Milligrams by Montiff, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Glycine | 500 mg | -- |
Other ingredients: Gelatin, Microcrystalline Cellulose, Silicon Dioxide, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one (1) to three (3) capsules daily, or as recommended by a health care professional. To be used as a dietary supplement in a normal food program. It is recommended that this product be taken with vitamins and minerals.*
FDA Disclaimer Statement
* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Storage
DO NOT REFRIGERATE.
STORE IN A COOL, DRY PLACE.
Precautions
KEEP OUT OF REACH OF CHILDREN.
General
Product#10481
Brand IP Statement(s)
(C) 1999 MONTIFF, INC. ALL RIGHTS RESERVED.
General Statements
MONTIFF - A DON TYSON COMPANY
Highest Quality Available
FDA Statement of Identity
Dietary Supplement
Formulation
Certified free of: Starch, corn, milk, wheat, yeast, sugar, eggs, salt, artificial colors, binders, flavors, preservatives and fish derivaties.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pure Glycine 500 Milligrams by Montiff label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pure Glycine 500 Milligrams by Montiff
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
Glycine monograph & interactionsOther (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Silicon Dioxide, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
Pure Glycine 500 Milligrams by Montiff Drug Interactions
HelloPharmacist Interaction Report
Montiff Pure Glycine 500 Milligrams interacts with one medication.
The single documented interaction is with clozapine (Clozaril), an antipsychotic used for schizophrenia. Glycine may worsen schizophrenia symptoms when added to clozapine therapy, and it might reduce clozapine's effectiveness, though the exact mechanism is unclear.
Read the full breakdown — every affected drug type, severity by severity
Although only one medication is documented to interact with this product, if you take clozapine, talk with your doctor or pharmacist before starting glycine. You'll want to discuss whether this combination makes sense for your situation.
Use the medication checker on this page to search for your exact medications and see whether any others are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pure Glycine 500 Milligrams?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pure Glycine 500 Milligrams interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Pure Glycine 500 Milligrams interact with drugs. Each result below shows which ingredient is responsible. Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with Pure Glycine 500 Milligrams — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pure Glycine 500 Milligrams with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Pure Glycine 500 Milligrams, from the product label.
Pure Glycine 500 Milligrams by Montiff: Common Questions
Does Pure Glycine 500 Milligrams by Montiff interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I experience?
How long is it safe to take this supplement?
Is glycine something my body makes naturally?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pure Glycine 500 Milligrams is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pure Glycine 500 Milligrams’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pure Glycine 500 Milligrams's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC