Pure L-Lysine 500 Milligrams Ingredients & Drug Interactions
by Montiff
What is this page for?
First and foremost: checking Pure L-Lysine 500 Milligrams against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pure L-Lysine 500 Milligrams is a dietary supplement by Montiff with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pure L-Lysine 500 Milligrams by Montiff
Ask about any prescription or over-the-counter medication and we check it for interactions with Pure L-Lysine 500 Milligrams by Montiff — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Pure L-Lysine 500 Milligrams by Montiff
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-lysine, an amino acid your body uses for protein synthesis and immune function. The capsule also holds three inactive ingredients — gelatin, microcrystalline cellulose, and magnesium stearate — which are standard binders and fillers that help form and stabilize the capsule.
Does it work?
Moderate evidence
L-lysine is possibly effective for herpes labialis (cold sores). For other uses — child growth, pressure ulcers, and diabetic foot ulcers — the evidence isn't established in the data we hold.
How safe is it?
Well-documented data
Lysine is generally well tolerated at typical doses, though high amounts may cause stomach upset, and long-term safety at supplemental levels isn't well studied. The most commonly reported side effects from oral use are abdominal pain, diarrhea, and indigestion.
There's one case report linking high-dose oral lysine to kidney inflammation that progressed to chronic kidney failure, though this is rare. Safety data for lysine supplements during pregnancy and breastfeeding is limited.
Lysine from food is fine, but if you're pregnant or nursing, talk with your doctor or pharmacist about whether a supplement is right for you, since we don't have enough reliable information to know either way.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist (a medication that works on serotonin receptors in the gut or brain), check with your doctor or pharmacist before using this product — L-lysine may reduce its effectiveness.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.
L-lysine may help with cold sores, though the evidence is modest. If you take a 5-HT4 agonist, check with your doctor or pharmacist first — this supplement could reduce how well that drug works.
At typical doses, lysine is generally well tolerated, though very high amounts might upset your stomach. If you're pregnant, nursing, or have kidney concerns, talk it over with your own healthcare provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pure L-Lysine 500 Milligrams, straight from the product label.
| Brand | Montiff |
|---|---|
| Barcode (UPC) | 683268104200 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2015 |
| DSLD ID | 42031 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pure L-Lysine 500 Milligrams by Montiff, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Lysine | 500 mg | -- |
Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one (1) to three (3) capsules daily, or as recommended by a health care professional. To be used as a dietary supplement in a normal food program. It is recommended that this product be taken with vitamins and minerals.
FDA Disclaimer Statement
* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Storage
DO NOT REFRIGERATE.
STORE IN A COOL, DRY PLACE.
Precautions
KEEP OUT OF REACH OF CHILDREN.
General
Product#10420
Brand IP Statement(s)
(C) 1999 MONTIFF, INC. ALL RIGHTS RESERVED.
General Statements
MONTIFF - A DON TYSON COMPANY
Highest Quality Available
FDA Statement of Identity
Dietary Supplement
Formulation
Certified free of: Starch, corn, milk, wheat, yeast, sugar, eggs, salt, artificial colors, binders, flavors, preservatives and fish derivatives.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pure L-Lysine 500 Milligrams by Montiff label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pure L-Lysine 500 Milligrams by Montiff
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
L-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Pure L-Lysine 500 Milligrams by Montiff Drug Interactions
HelloPharmacist Interaction Report
Pure L-Lysine 500 Milligrams by Montiff contains one active ingredient — L-lysine — which has one documented interaction.
L-lysine may reduce the effects of 5-HT4 agonists (drugs that boost a specific serotonin receptor to treat certain GI or other conditions). The interaction is rated Minor in severity.
Animal research suggests lysine acts as a partial antagonist to this receptor, which could theoretically blunt how these medications work.
Read the full breakdown — every affected drug type, severity by severity
Additionally, the interaction spans just one individual medication type. If you take a 5-HT4 agonist, run it through the search tool below or check with your doctor or pharmacist before starting this supplement to confirm there's no concern for your specific situation.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pure L-Lysine 500 Milligrams?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pure L-Lysine 500 Milligrams interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Pure L-Lysine 500 Milligrams interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with Pure L-Lysine 500 Milligrams — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pure L-Lysine 500 Milligrams with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for Pure L-Lysine 500 Milligrams, from the product label.
Pure L-Lysine 500 Milligrams by Montiff: Common Questions
Does Pure L-Lysine 500 Milligrams by Montiff interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will L-lysine help my cold sores?
What are the side effects of L-lysine?
Is L-lysine safe to take if I'm pregnant?
Can I take L-lysine while breastfeeding?
What is L-lysine used for in the body?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pure L-Lysine 500 Milligrams is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pure L-Lysine 500 Milligrams’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pure L-Lysine 500 Milligrams's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC