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Dietary supplement

Pure L-Methionine 500 Milligrams Ingredients & Drug Interactions

by Montiff

Pure L-Methionine 500 Milligrams label
See full label image
Capsule Category: Amino Acid/protein
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure L-Methionine 500 Milligrams against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Pure L-Methionine 500 Milligrams is a dietary supplement by Montiff with 1 active ingredient. Its ingredients are commonly taken for acetaminophen (tylenol) overdose support, liver health, urinary tract acidification.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Pure L-Methionine 500 Milligrams by Montiff

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: L-methionine, an amino acid your body needs to make proteins and other compounds. The capsule itself is filled with inactive ingredients—microcrystalline cellulose (a binder), magnesium stearate (a lubricant), and gelatin (the capsule material).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Methionine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Methionine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Neural tube birth defects — rated "Possibly Effective" (Natural Medicines).

The evidence for L-methionine's usefulness is limited. It's rated possibly effective for preventing neural tube birth defects (spinal and brain defects in early pregnancy), though the data isn't conclusive.

For acetaminophen poisoning, hay fever, asthma, breast cancer, the evidence is too thin to rate it one way or another — we simply don't have enough reliable studies to say whether it works.

The evidence, ingredient by ingredient Methionine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Methionine from food is generally well tolerated. As a high-dose supplement, though, the picture changes: it should be used only with medical guidance.

Common side effects include dizziness, drowsiness, low blood pressure, irritability, vomiting, headache, and increased calcium loss in urine. Rare but serious effects include brain swelling and liver-related confusion.

High-dose methionine (75–100 mg per kilogram of body weight daily) may raise homocysteine, a marker linked to heart and vessel disease; however, not all studies confirm this effect. During pregnancy, food amounts are fine, but supplement doses have not been proven safe — talk with your doctor before taking it if you're pregnant.

For breastfeeding, safety data on supplement doses is limited; check with your pharmacist or doctor first.

Side effects, ingredient by ingredient Methionine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for L-methionine with the medications we could check. That said, because this supplement can lower blood pressure, confirm with your doctor or pharmacist before taking it alongside blood pressure medications or if you have heart or vessel disease.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

L-methionine is an amino acid with limited proven uses; it's possibly effective for neural tube defects in pregnancy but lacks strong evidence for other conditions listed. It's generally well tolerated in food amounts, but supplement doses require medical oversight, especially if you have blood pressure or heart concerns.

Talk with your doctor or pharmacist before starting, and don't take it during pregnancy or breastfeeding without their input.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure L-Methionine 500 Milligrams, straight from the product label.

Brand Montiff
Barcode (UPC) 683268106006
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42067
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure L-Methionine 500 Milligrams by Montiff, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
UPC/BARCODE
683268106006
IngredientAmount% DV
L-Methionine500 mg--

Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one to three capsules daily, or as recommended by a health care professional. To be used as a Dietary supplement in a normal food program. It is recommended that this product be taken with vitamins and minerals.

Formulation

Contains no Starch, Corn, Milk, Wheat, Yeast, Sugar, Eggs, Salt, Artificial Colors, Binders, Flavors, Preservatives or fish derivatives.

Storage

Do Not Refrigerate.

Store in a cool, dry place.

Precautions

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

Product#10600

Brand IP Statement(s)

(C) 2001 MONTIFF, INC. ALL RIGHTS RESERVED.

General Statements

MONTIFF

Highest Quality Available

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure L-Methionine 500 Milligrams by Montiff label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure L-Methionine 500 Milligrams label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure L-Methionine 500 Milligrams by Montiff

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

L-Methionine

No known
interactions
500 mg per serving

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...

L-Methionine monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure L-Methionine 500 Milligrams by Montiff Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Pure L-Methionine 500 Milligrams. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Pure L-Methionine 500 Milligrams, from the product label.

Montiff

See all Montiff products
Name
Montiff, Inc.
City
Santa Monica
State
CA
ZipCode
90404
Pharmacist Counseling Corner

Pure L-Methionine 500 Milligrams by Montiff: Common Questions

Does Pure L-Methionine 500 Milligrams by Montiff interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Pure L-Methionine 500 Milligrams. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Pure L-Methionine 500 Milligrams contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my allergies or asthma?
The evidence isn't strong enough to say. L-methionine is rated as having insufficient reliable evidence for hay fever and asthma, meaning we don't have enough solid studies to know whether it actually helps with these conditions.
What's methionine supposed to do in my body?
Methionine is an amino acid—a building block your body uses to make proteins and other compounds. It's in many foods, and your body makes some on its own. As a supplement at high doses, it needs medical guidance to use safely.
What are the most common side effects I might feel?
Dizziness, drowsiness, low blood pressure, irritability, and vomiting are the most common. Headache, increased calcium loss in urine, and raised white blood cell counts have also been reported. Serious effects like brain swelling are rare.
Is this safe to take while I'm pregnant?
Food amounts of methionine are fine during pregnancy. However, supplement doses have not been proven safe, so do not take this without talking to your doctor first.
Can I take this while breastfeeding?
Safety data on supplement doses while breastfeeding is not well studied. Talk with your pharmacist or doctor before using it to get personalized advice.
Could this raise my cholesterol or heart risk?
High doses of methionine may increase homocysteine levels, a marker linked to heart and vessel disease risk. However, not all studies confirm this happens, and some research in people with type 2 diabetes found no such effect. Check with your doctor, especially if you have heart concerns.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure L-Methionine 500 Milligrams is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure L-Methionine 500 Milligrams label
Go deeper

The Full Monographs Behind Pure L-Methionine 500 Milligrams’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph →
Sources

Sources & How We Checked

Pure L-Methionine 500 Milligrams's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
  4. Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
  7. Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
  10. Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
  12. Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed

See these in context on the Methionine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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