Resveratrol Plus+ Ingredients & Drug Interactions
by Member's Mark
What is this page for?
First and foremost: checking Resveratrol Plus+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Resveratrol Plus+ is a dietary supplement by Member's Mark with 2 active ingredients. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, anti-aging.Based on those ingredients, 822 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Resveratrol Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Resveratrol Plus+ by Member's Mark
Ask about any prescription or over-the-counter medication and we check it for interactions with Resveratrol Plus+ by Member's Mark — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Resveratrol Plus+ by Member's Mark
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
Member's Mark Resveratrol Plus+ contains three active ingredients: trans-resveratrol, trans-pterostilbene, and a resveratrol complex with various glycosides. Trans-resveratrol is a naturally occurring polyphenol found in grapes and red wine; the other ingredients are related compounds thought to support similar functions in your body.
The product also contains several inactive ingredients—gelatin (capsule shell), rice concentrate, magnesium stearate, silica, titanium dioxide, and colorants (FD&C Red #3 and FD&C Blue #1)—to hold the capsule together and keep it stable on the shelf.
Does it work?
Leans against
For obesity and allergic rhinitis (hay fever), trans-resveratrol is rated possibly effective based on available evidence. For cardiovascular disease and high cholesterol, the evidence currently suggests it is possibly ineffective.
We do not hold effectiveness data for trans-pterostilbene or the glycoside blend in isolation, so those components' benefits are not established in our records.
How safe is it?
Well-documented data
Trans-resveratrol is generally well tolerated at typical supplement doses. At higher doses, it can cause digestive upset—diarrhea, gastrointestinal discomfort, and loose stools are the most common side effects.
There are isolated reports of headache, fatigue, memory loss, and skin rash in clinical use, though causality hasn't been confirmed. Long-term safety at high doses isn't fully known.
The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to confirm it's safe in those situations. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel)—resveratrol may increase bleeding risk. Also confirm if you take medications broken down by your liver's CYP2C19, CYP1A2, CYP3A4, or CYP2E1 enzymes, as resveratrol may raise their levels in your blood.
Muscle relaxants like chlorzoxazone showed a significant increase in blood levels in one study.
The bottom line
Scorecard at a glancePartially disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Resveratrol Plus+ may help with obesity and allergic rhinitis, but evidence is limited. The main concern is interaction with blood thinners and drugs metabolized by certain liver enzymes—especially if you take high doses.
If you're on any prescription medications, particularly anticoagulants or muscle relaxants, confirm with your doctor or pharmacist before starting this supplement. Pregnant and breastfeeding people should also check with their healthcare provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Resveratrol Plus+, straight from the product label.
| Brand | Member's Mark |
|---|---|
| Barcode (UPC) | 078742195698 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Sep 22, 2022 |
| DSLD ID | 277367 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Resveratrol Plus+ by Member's Mark, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Trans-Resveratrol | 100 mg | -- |
| Trans-Pterostilbene | 40 mcg | -- |
| Resveratrol Complex | 300 mg | -- |
| Glycosides | 0 NP | -- |
Other ingredients: Gelatin, Rice Concentrate, Magnesium Stearate, Silica, Titanium Dioxide, FD&C Red #3, FD&C Blue #1
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Now 50% more pills
100% Money back guarantee Superior quality and performance
We would like to hear from you with any comments or suggestions. In the continental U.S. or Canada, you can call us toll-free at 1-800-352-8674 from 8 a.m. to 5 p.m. EST Monday-Friday. You can also send us an email using the feedback icon at SamsClub.com.
Why is this formula superior? The amount of active trans-resveratrol is key.
Formulation
Supports heart health Cardiovascular/antioxidant The secret of red wine for total heart health
Member's Mark Resveratol Plus+ has been formulated to promote cardiovascular health and to provide superior antioxidant protection. Made famous by the studies on red wine, Resveratrol has been discovered to be of important benefit to your health.
This product is not derived from, nor does it contain, red wine.
Gluten free
Formula
Provides 100 mg trans-resveratrol With active form of trans-resveratrol With pterostilbene for superior antioxidant protection
1 capsule = 100 glasses of red wine (resveratrol content) and 200 blueberries (pterostilbene content)
Ours: contains a clinical dose, 100 mg of active trans-resveratrol. Others: typically contain low or trace amounts and often do not specifically state the amount of active trans-resveratrol. Our formula contains Pterostilbene, an antioxidant naturally found in blueberries. Pterostilbene has been shown in laboratory tests to work synergistically with trans-resveratrol to provide enhanced antioxidant properties for anti-aging benefits.
Member's Mark Resveratol Plus+ contains Polygonum cuspidatum and Vitis vinifera, in order to provide you with the benefits of Resveratrol in a small, concentrated dosage.
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Laboratory Tested Quality Assured
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take one capsule daily with a meal.
Precautions
For adults only. Consult your doctor before taking any supplement.
Warning: If you are pregnant, nursing or taking any prescription medications, consult your doctor before using this product.
Discontinue use and consult a doctor if any adverse reactions occur.
Keep out of the reach of children.
For your protection do not use if seal under cap is broken or missing.
Storage
Keep in a cool, dry place, with cap tightly closed and avoid excessive heat.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Resveratrol Plus+ by Member's Mark label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Resveratrol Plus+ by Member's Mark
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Trans-Pterostilbene
Resveratrol Complex
Interacts with822 drugs
Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...
Resveratrol Complex monograph & interactions- › Trans-Resveratrol
- › Glycosides
Other (inactive) ingredients: Gelatin, Rice Concentrate, Magnesium Stearate, Silica, Titanium Dioxide, FD&C Red #3, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.
Resveratrol Plus+ by Member's Mark Drug Interactions
HelloPharmacist Interaction Report
Member's Mark Resveratrol Plus+ contains trans-resveratrol, which interacts with several medication types.
The most serious concern is with blood thinners and antiplatelet drugs (like warfarin, aspirin, or clopidogrel): resveratrol may increase bleeding risk if you're already taking these medications.
Read the full breakdown — every affected drug type, severity by severity
Resveratrol can also theoretically increase blood levels of drugs broken down by your liver's CYP enzymes—specifically CYP2C19, CYP1A2, CYP3A4, and CYP2E1. These are moderate-severity interactions based on lab research, though clinical evidence in humans is limited.
A clinical study at high doses (3000 mg daily) showed no dose adjustment was needed for CYP3A4 drugs, but the interaction remains theoretically possible at supplement doses. One pharmacokinetic study did show resveratrol increased chlorzoxazone (a muscle relaxant) levels by about 54%.
Additionally, we could not check trans-pterostilbene, glycosides, or their component ingredients—no interaction data is on file for them. Altogether, these interactions span 823 individual medications.
Before you start this product, check your exact medications with the search tool on this page or confirm with your doctor or pharmacist, especially if you take blood thinners, antiplatelet drugs, or medications metabolized by those liver enzymes.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Resveratrol Plus+?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Resveratrol Plus+ interact with 822 drugs. Click any drug to see the details.
1 of the 2 ingredients in Resveratrol Plus+ interact with drugs. Each result below shows which ingredient is responsible. Resveratrol Complex
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol Complex + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Resveratrol Complex + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol Complex + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol Complex + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol Complex + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Resveratrol Complex + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol Complex + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Resveratrol Complex + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol Complex + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Resveratrol Complex + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol Complex + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol Complex + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Resveratrol Complex + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol Complex + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol Complex + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol Complex + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Resveratrol Complex + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol Complex + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol Complex + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol Complex + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol Complex + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol Complex + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol Complex + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol Complex + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol Complex + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Resveratrol Complex + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol Complex + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Resveratrol Complex + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Resveratrol Complex + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Resveratrol Plus+ — through 1 ingredient. Tap an ingredient for the detail:
Resveratrol ComplexCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol Complex + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Resveratrol Plus+ with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Resveratrol Complex
Anticoagulant/Antiplatelet Drugs
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.
Brand information
Manufacturer and brand details for Resveratrol Plus+, from the product label.
Member's Mark
- Name
- Sam's West, Inc.
- City
- Bentonville
- State
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Resveratrol Plus+ by Member's Mark: Common Questions
Does Resveratrol Plus+ by Member's Mark interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does trans-resveratrol do?
Will this product make me bleed if I'm on a blood thinner?
What are the most common side effects?
Is it safe to take during pregnancy or breastfeeding?
Does this product interact with liver enzyme medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Resveratrol Plus+’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Resveratrol Plus+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 24 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Resveratrol 24 references
- Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113.
- Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
- Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
- Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
- Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
- Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
- Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
- Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
- Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
- Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
- Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
- Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
- Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
- Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
- la, Porte C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D., Singhal, N., and Cameron, D. W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Cli PubMed
- Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive
- Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
- Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
- Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
- Lin CT, Sun XY, Lin AX. Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study. Ren Fail. 2016;38(2):214-21. PubMed
- Li Q, Yang G, Xu H, Tang S, Lee WY. Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther 2021;21(1):214. PubMed
- McCreary MR, Schnell PM, Rhoda DA. Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19). Sci Rep 2022;12(1):10978. PubMed
- Abdelhaleem IA, Brakat AM, Adayel HM, Asla MM, Rizk MA, Aboalfetoh AY. The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis. Med Clin (Barc) 2022;158(12):576-585. PubMed
- Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Contact Dermatitis 2022.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC