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Dietary supplement

Rho Nutrition Liposomal DIM+ Liquid Ingredients & Drug Interactions

by Rho Nutrition

Rho Nutrition Liposomal DIM+ Liquid label
See full label image
Liquid Category: Dietary Supplement
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Jul 29, 2026 · Label data verified by our pharmacy team
What is this page for?

First and foremost: checking Rho Nutrition Liposomal DIM+ Liquid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rho Nutrition Liposomal DIM+ Liquid is a dietary supplement by Rho Nutrition with 2 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 270 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Diindolylmethane, Broccoli seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Rho Nutrition Liposomal DIM+ Liquid by Rho Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Rho Nutrition Liposomal DIM+ Liquid by Rho Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Rho Nutrition Liposomal DIM+ Liquid by Rho Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 29, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.

This liquid contains 2 active ingredients: diindolylmethane (a compound from cruciferous vegetables like broccoli and cabbage) and broccoli seed extract. These are combined with inactive ingredients including purified shilajit, glycerin, pineapple fruit powder, sunflower lecithin, orange juice powder, citric acid, and potassium sorbate.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: estrogen metabolism and hormone balance support.
  • We looked for evidence on: Premenstrual syndrome (PMS), Mastalgia, Benign prostatic hyperplasia (BPH), menopause symptoms, perimenopause, hormonal acne.
  • The closest evidence on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Mastalgia, Premenstrual syndrome (PMS).

The evidence we hold doesn't establish that this product works for any condition. Diindolylmethane has insufficient reliable evidence for benign prostatic hyperplasia, breast cancer, uterine cancer, cervical dysplasia, colorectal cancer, and mastalgia.

Broccoli seed extract shows possibly effective evidence for colorectal cancer, but insufficient evidence for bladder cancer, breast cancer, prostate cancer, fibromyalgia, and gastric cancer. If you're considering this for a specific health goal, talk with your doctor or pharmacist about what the current evidence shows.

The evidence, ingredient by ingredient Diindolylmethane Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients are rated likely safe in pregnancy and lactation based on the data we hold. Diindolylmethane is generally well tolerated in short-term studies, though long-term safety isn't well established.

Common side effects include diarrhea, gas, headache, nausea, rash, and vomiting. A rare serious reaction called DRESS (drug rash with eosinophilia and systemic symptoms) has been reported.

Broccoli seed extract, as a concentrated supplement, is less studied than broccoli as food; loose stools, diarrhea, abdominal pain, and cramping have been reported, especially at high doses. Because diindolylmethane may affect hormones, the safety data advises against use during pregnancy—discuss this with your doctor or pharmacist before taking it if you're pregnant or planning to be.

Side effects, ingredient by ingredient Diindolylmethane Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Diindolylmethane, Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 270 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check any medications you're on that are metabolized by CYP2A6 (severity: Moderate), estrogens or hormone therapies (Moderate), sodium-depleting water pills or diuretics (Moderate), or CYP1A2 substrates (Minor). No interactions are documented for the inactive ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines two ingredients with documented interactions, most seriously with blood pressure and water-retention medications and with enzyme-dependent drugs. Evidence for its effectiveness isn't established in our data.

If you take any prescription medication—especially hormonal birth control, hormone replacement therapy, water pills, or drugs your doctor told you are enzyme-sensitive—check your medications on this page and talk with your own doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 29, 2026.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rho Nutrition Liposomal DIM+ Liquid, straight from the product label.

Brand Rho Nutrition
Barcode (UPC) 850060096341
Net contents 6 fl oz | 180 mL
Market status On market
Added to our catalog Jul 29, 2026
Product type Dietary Supplement
Supplement form Liquid
Dietary claims / uses Estrogen metabolism support, Hormone balance, Detox pathway support, Mood regulation support, Perimenopause/menopause wellness support, Balanced estrogen-to-androgen ratio in men
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rho Nutrition Liposomal DIM+ Liquid by Rho Nutrition, compiled by our pharmacy team from the manufacturer's label.

Supplement Facts

Daily Value (DV) Target Group(s):
N/A
Minimum serving Sizes:
6 mL
Maximum serving Sizes:
6 mL
Servings per container
30
UPC/BARCODE
850060096341
IngredientAmount% DV
Diindolylmethane----
Broccoli seed extract----

Other ingredients: purified Shilajit, Glycerin, Pineapple fruit powder, non-GMO Sunflower Lecithin, Orange juice powder, Citric Acid, Potassium Sorbate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested Use

Take 6 milliliters (just over one teaspoon) once daily. Can be taken anytime with or without food.

Marketing

Hormonal Balance Support

Supports Estrogen Metabolism, Hormone Balance & Detox Pathways – Men & Women

Ultra High Absorption Liposomal DIM Delivery

Enhanced with Sulforaphane Glucosinolate (SGS) – Supports Phase II detoxification enzymes that complement DIM's role in estrogen metabolism pathways.

Other

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rho Nutrition Liposomal DIM+ Liquid by Rho Nutrition label

The product's label imagery, on file with our pharmacy team. Tap to enlarge.

Rho Nutrition Liposomal DIM+ Liquid label

Label images reflect the product version on file with our pharmacy team. Always read your actual product label.

What’s inside

The Ingredients in Rho Nutrition Liposomal DIM+ Liquid by Rho Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Diindolylmethane

Interacts with
269 drugs
Form: Liposomal

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolylmethane monograph & interactions

Broccoli seed extract

Interacts with
187 drugs
Form: from broccoli seed extract

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli seed extract monograph & interactions

Other (inactive) ingredients: Purified Shilajit, Glycerin, Pineapple fruit powder, Non-GMO Sunflower Lecithin, Orange juice powder, Citric Acid, Potassium Sorbate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rho Nutrition Liposomal DIM+ Liquid by Rho Nutrition Drug Interactions

Want to check YOUR meds against Rho Nutrition Liposomal DIM+ Liquid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
270Drugs
270 Moderate

Ingredients driving the most interactions

Diindolylmethane 269
Broccoli seed extract 187

Individual Drug Interactions

The ingredients in Rho Nutrition Liposomal DIM+ Liquid interact with 270 drugs. Click any drug to see the details.

2 of the 2 ingredients in Rho Nutrition Liposomal DIM+ Liquid interact with drugs. Each result below shows which ingredient is responsible. Diindolylmethane Broccoli seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Rho Nutrition Liposomal DIM+ Liquid with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions

Broccoli seed extract2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rho Nutrition Liposomal DIM+ Liquid, from the product label.

Rho Nutrition

See all Rho Nutrition products
Pharmacist Counseling Corner

Rho Nutrition Liposomal DIM+ Liquid by Rho Nutrition: Common Questions

Does Rho Nutrition Liposomal DIM+ Liquid by Rho Nutrition interact with any medications?
Yes. Based on its ingredients, Rho Nutrition Liposomal DIM+ Liquid has a known interaction with 270 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rho Nutrition Liposomal DIM+ Liquid contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this work for prostate or cancer concerns?
The evidence in our data doesn't establish that it does. Broccoli seed extract shows possibly effective evidence only for colorectal cancer; diindolylmethane has insufficient evidence for all the conditions listed. Talk with your doctor about what the research actually supports for your situation.
Is it safe during pregnancy?
Both ingredients are rated likely safe in pregnancy based on the data we hold. However, because diindolylmethane may affect hormones, the safety data advises against use in pregnancy. Discuss this with your own doctor or pharmacist—they know your full health picture and can give you personalized guidance.
What are the most common side effects?
Diindolylmethane commonly causes diarrhea, gas, headache, nausea, rash, and vomiting. Broccoli seed extract commonly causes loose stools, diarrhea, abdominal pain, and cramping, especially at higher doses. These are generally mild and short-term.
Why do I need to check my medications?
Both ingredients speed up how your liver breaks down certain drug categories, which can lower how well those medications work. Estrogen hormones and water pills also interact with diindolylmethane in ways that might reduce their effects. Your doctor or pharmacist can tell you if any of your drugs fall into these groups.
Is broccoli seed extract the same as eating broccoli?
No. Eating broccoli as food is generally fine; a concentrated seed extract is much more potent and less studied. The safety data advises caution with concentrated extracts unless your doctor approves.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rho Nutrition Liposomal DIM+ Liquid label
Go deeper

The Full Monographs Behind Rho Nutrition Liposomal DIM+ Liquid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

Rho Nutrition Liposomal DIM+ Liquid's label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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