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Dietary supplement

Saffron 30 mg Ingredients & Drug Interactions

by Exir USA

Saffron 30 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Saffron 30 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Saffron 30 mg is a dietary supplement by Exir USA with 2 active ingredients. Its ingredients are commonly taken for depression and low mood, anxiety, pms symptoms.Based on those ingredients, 521 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Saffron. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Saffron 30 mg by Exir USA

Ask about any prescription or over-the-counter medication and we check it for interactions with Saffron 30 mg by Exir USA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Saffron 30 mg by Exir USA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This tablet contains two active ingredients: saffron and saffron extract, delivering a combined 30 mg dose. Both forms come from the same spice and work the same way in your body.

The product also includes inactive ingredients—vegetable cellulose, rice extract blend, and rice bran—which serve as fillers and binders to hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Saffron's overall clinical evidence instead.

Moderate

Some clinical evidence supports Saffron for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Alzheimer disease — rated "Possibly Effective" (Natural Medicines).
  • On file: Chemotherapy-induced peripheral neuropathy — rated "Possibly Effective" (Natural Medicines).

The data we hold shows saffron is possibly effective for two conditions: chemotherapy-induced peripheral neuropathy (nerve damage from cancer drugs) and Alzheimer disease. "Possibly effective" means there's clinical evidence supporting it, but it's not yet conclusive. For other uses, the evidence isn't established in our data.

The evidence, ingredient by ingredient Saffron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saffron extract is generally well tolerated at supplement doses. The most common side effects are gastrointestinal complaints, nausea, sedation, and vomiting.

Rarely, anaphylaxis (a severe allergic reaction) has been reported; if you've ever had an allergy to saffron, avoid this product. At this 30 mg daily dose for 6 weeks, mood changes like anxiety or agitation occurred at rates similar to placebo, but at higher doses (30 mg twice daily over 26 weeks) those effects were reported.

One isolated case of agitation was tied to a saffron compound, though it's unclear if it was related to treatment. The safety data advises against saffron in medicinal or supplement amounts during pregnancy, as it may stimulate the uterus.

There isn't enough reliable safety information for breastfeeding, so talk with your doctor or pharmacist before using it if you're nursing. High doses can be toxic, so stick to the label dose.

Side effects, ingredient by ingredient Saffron

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saffron.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 521 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your own doctor or pharmacist if you use CNS depressants (sleeping pills, anti-anxiety drugs, opioids), blood pressure medications (antihypertensive drugs), diabetes medications, or caffeine regularly. Saffron has Moderate interactions with all of these and could change how they work in your body.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Consider saffron if you're interested in possibly effective support for chemotherapy-related nerve pain or Alzheimer disease and you don't take blood pressure, diabetes, or sedating medications or use caffeine regularly. If you do take any of those, talk with your doctor or pharmacist before adding this product — it could affect how those drugs work.

Avoid it if you're pregnant, nursing, or allergic to saffron.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Saffron 30 mg, straight from the product label.

Brand Exir USA
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214271
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Saffron 30 mg by Exir USA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
120
IngredientAmount% DV
Saffron15 mg--
Saffron extract15 mg--

Other ingredients: Vegetable Cellulose, Rice extract Blend, Rice Bran

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Made in the USA in a FDA Registered Facility

Vegan

Allergen Free

Made With No GMO Ingredients

Exotic Spice Incredible Benefits

No artificial coloring or preservatives.

Artificial Excipient Free

Seals/Symbols

GMP Good Manufacturing Practice Consistent Quality

FDA Statement of Identity

Dietary Supplement

Formula

30mg High Potency

Suggested/Recommended/Usage/Directions

Recommendation: 1 Tablet 2-3 times daily

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure and prevent any disease.

Storage

Keep tightly closed in a cool, dry, place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Saffron 30 mg by Exir USA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Saffron 30 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Saffron 30 mg by Exir USA

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Saffron

Interacts with
521 drugs
15 mg per serving

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research us...

Saffron monograph & interactions

Saffron extract

Interacts with
521 drugs
15 mg per serving Form: Crocin, Crocus sativus L. stigma powder, Safranal

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research us...

Saffron extract monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Rice extract Blend, Rice Bran. These complete the product’s ingredient list but are not active constituents.

Interaction report

Saffron 30 mg by Exir USA Drug Interactions

Want to check YOUR meds against Saffron 30 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
521Drugs
521 Moderate

Ingredients driving the most interactions

Saffron 521

Individual Drug Interactions

The ingredients in Saffron 30 mg interact with 521 drugs. Click any drug to see the details.

1 of the 2 ingredients in Saffron 30 mg interact with drugs. Each result below shows which ingredient is responsible. Saffron

Each ingredient & the kinds of drugs it affects

For each ingredient in Saffron 30 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saffron4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Saffron full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Saffron 30 mg, from the product label.

Exir USA

See all Exir USA products
Name
Epicure Garden
Phone Number
1-888-381-0106
Web Address
www.exirsaffron.com
Pharmacist Counseling Corner

Saffron 30 mg by Exir USA: Common Questions

Does Saffron 30 mg by Exir USA interact with any medications?
Yes. Based on its ingredients, Saffron 30 mg has a known interaction with 521 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Saffron 30 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is saffron safe to take if I'm pregnant or breastfeeding?
The safety data advises against saffron at medicinal or supplement doses during pregnancy because it may stimulate the uterus. For breastfeeding, there isn't enough reliable safety information. Talk with your doctor or pharmacist before using it if you're pregnant or nursing.
What are the most common side effects?
Most common are gastrointestinal complaints, nausea, sedation, and vomiting. Serious allergic reactions like anaphylaxis are rare but have been reported. If you've ever had an allergy to saffron or saffron-containing foods, avoid this product.
Can this cause mood changes?
At this 30 mg daily dose for 6 weeks, mood effects like anxiety or agitation occurred at rates similar to placebo. At twice this dose over a longer period, anxiety and hypomania were reported. One case of agitation was reported, though it's unclear if it was directly caused by the saffron.
Does saffron actually work for anything?
The data we hold shows saffron is possibly effective for chemotherapy-induced peripheral neuropathy (nerve damage from cancer drugs) and Alzheimer disease. "Possibly effective" means clinical evidence supports it, but it's not yet conclusive.
What's the difference between saffron and saffron extract in this product?
Both come from the same spice and work the same way in your body. This product contains both forms to deliver 30 mg total. They carry the same interaction warnings and side effect profile.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Saffron 30 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Saffron 30 mg label
Go deeper

The Full Monographs Behind Saffron 30 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph →
Sources

Sources & How We Checked

Saffron 30 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saffron 22 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Feo F, Martinez J, Martinez A, et al. Occupational allergy in saffron workers. Allergy 1997;52:633-41. PubMed
  5. Wuthrich B, Schmid-Grendelmeyer P, Lundberg M. Anaphylaxis to saffron. Allergy 1997;52:476-7. PubMed
  6. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 2005;19:148-51.
  7. Safarinejad MR, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasth
  8. Fatehi, M., Rashidabady, T., and Fatehi-Hassanabad, Z. Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J Ethnopharmacol. 2003; PubMed
  9. Modaghegh, M. H., Shahabian, M., Esmaeili, H. A., Rajbai, O., and Hosseinzadeh, H. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine. 2008;15(12):1032-1037. PubMed
  10. Imenshahidi, M., Hosseinzadeh, H., and Javadpour, Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother.Res 12-9-2009;
  11. Zhang, Y., Shoyama, Y., Sugiura, M., and Saito, H. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol.Pharm Bull. 1994;17(2):217-221. PubMed
  12. Wuthrich, B., Schmid-Grendelmeyer, P., and Lundberg, M. Anaphylaxis to saffron. Allergy 1997;52(4):476-477. PubMed
  13. Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and plac
  14. Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, Foroughifar T, Salimi S, Akhondzadeh S. Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial. Ph PubMed
  15. Kianbakht S, Ghazavi A. Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial. Phytother Res. 2011 Dec;25(12):1801-5. PubMed
  16. Mazidi M, Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Mokhber N, Ghayour-Mobarhan M, Ferns GA. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J C
  17. Safarinejad MR, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment. Int J Impo PubMed
  18. Talaei A, Hassanpour Moghadam M, Sajadi Tabassi SA, Mohajeri SA. Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial. J Affect Disord. 2 PubMed
  19. Azimi P, Ghiasvand R Feizi A, Hariri M, Abbasi B. Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes. Rev Diabet Stud. 2014 Fall-Winter;11(3-4
  20. Begas E, Bounitsi M, Kilindris T, et al. Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers. Food Chem Toxicol. 2019;130:32-43. PubMed
  21. Moravej Aleali A, Amani R, Shahbazian H, Namjooyan F, Latifi SM, Cheraghian B. The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabet
  22. Abbaszadeh-Mashkani S, Hoque SS, Banafshe HR, Ghaderi A. The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment. Phytother Res. 2021; PubMed

See these in context on the Saffron monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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