Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Liver Care Ingredients & Drug Interactions

by Exir USA

Liver Care label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Liver Care against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Liver Care is a dietary supplement by Exir USA with 5 active ingredients. Its ingredients are commonly taken for immune support, fever, blood sugar support.Based on those ingredients, 612 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guduchi. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Liver Care by Exir USA

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HelloPharmacist Scorecard of Liver Care by Exir USA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (425 mg) without saying how much of each component you get.

Liver Care contains 5 active ingredients in a proprietary blend: guduchi, phyllanthus, bringaraj, tephrosia purpurea, and nirgundi. Guduchi (Tinospora cordifolia) is a traditional herb used to support liver and immune function.

The other four are traditional Ayurvedic botanicals chosen for liver support, though their roles are grouped in the proprietary blend formula. The capsule itself is made from vegetable cellulose with rice concentrate as a filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Tinospora Cordifolia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Optimal liver health and function.
  • We looked for evidence on: Hepatitis, Hyperlipidemia, Hypertriglyceridemia, Liver cirrhosis, Non-alcoholic fatty liver disease, Liver fibrosis.
  • The closest evidence on file: Tinospora Cordifolia is rated "Insufficient Reliable Evidence To Rate" for Hepatitis (Natural Medicines).
  • Also on file: Tinospora Cordifolia is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertriglyceridemia.

Guduchi has clinical evidence showing it is possibly effective for type 2 diabetes — studies show it can reduce fasting blood glucose and glycated hemoglobin (a measure of long-term blood sugar control). For hay fever, asthma, athletic performance, cancer, and hepatitis, the evidence we hold is insufficient to rate how well it works.

No effectiveness data is available for the other ingredients in this product.

The evidence, ingredient by ingredient Tinospora Cordifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, guduchi is generally well tolerated. The most common side effects in trials are headache and nasal pain.

However, rare but serious liver injury has been reported — in case series, 49 patients developed autoimmune hepatitis, acute hepatitis, worsening of chronic liver disease, or acute liver failure after 42–90 days of use, sometimes as part of combination supplements; 2 required transplant and 4 died. Because of these reports, guduchi should be used carefully and ideally under guidance, especially if you have existing liver problems.

Safety has not been established in pregnancy, so it is best avoided. There is not enough reliable safety information for breastfeeding, so avoid use while nursing.

No adverse-effect data is on file for the other ingredients in this blend.

Side effects, ingredient by ingredient Tinospora Cordifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tinospora Cordifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 612 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take diabetes medications, check with your doctor or pharmacist first — guduchi can lower blood sugar, and combining it with diabetes drugs raises the risk of low blood sugar (hypoglycemia). Also double-check if you take immunosuppressants (such as after organ transplant or for autoimmune conditions) or any medications metabolized by the liver enzymes CYP2D6, CYP2C19, CYP1A2, or CYP2C9, since guduchi may raise their levels.

Your pharmacist can help you sort through your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Liver Care is built around guduchi, which has evidence for possibly helping type 2 diabetes but carries theoretical risks with several medication types — most notably diabetes drugs and immunosuppressants — and rare but serious liver injury reports. If you take diabetes medications, immunosuppressants, or any prescription drug your liver metabolizes, talk with your doctor or pharmacist before starting this product.

Do not use in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Liver Care, straight from the product label.

Brand Exir USA
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214300
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Liver Care by Exir USA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Proprietary Blend425 mg--
Guduchi0 NP--
Phyllanthus0 NP--
Bringaraj0 NP--
Tephrosia purpurea0 NP--
Nirgundi0 NP--

Other ingredients: Vegetable Cellulose, Rice concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Made in the USA in FDA Registered Facility

Gluten Free No GMO Allergen Free

Vegan

Optimal Liver Health & Function

Liver, Kidney, Heart + Immune Support

No artificial coloring or preservatives

Artificial Excipient Free

Seals/Symbols

Good Manufacturing Practice

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure and prevent any disease.

Formula

Kosher Certified

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: 1 capsule 2-3 times daily

Storage

Keep tightly closed in a cool, dry, place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Liver Care by Exir USA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Liver Care label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Liver Care by Exir USA

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

425 mg per serving
  • › Guduchi
  • › Phyllanthus
  • › Bringaraj
  • › Tephrosia purpurea
  • › Nirgundi

Other (inactive) ingredients: Vegetable Cellulose, Rice concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Liver Care by Exir USA Drug Interactions

Want to check YOUR meds against Liver Care?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
612Drugs
612 Moderate

Ingredients driving the most interactions

Guduchi 612

Individual Drug Interactions

The ingredients in Liver Care interact with 612 drugs. Click any drug to see the details.

1 of the 5 ingredients in Liver Care interact with drugs. Each result below shows which ingredient is responsible. Guduchi

Each ingredient & the kinds of drugs it affects

For each ingredient in Liver Care with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Guduchi6 drug types · 612 drugs

Antidiabetes Drugs

Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research in adults with type 2 diabetes shows that Tinospora cordifolia can reduce fasting blood glucose and glycated hemoglobin. Additionally, animal research shows that Tinospora cordifolia has hypoglycemic effects.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that Tinospora cordifolia extract inhibits CYP1A2 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C19 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2C9. Animal research shows that Tinospora cordifolia extract 400 mg/kg twice daily for 14 days reduces the clearance and increases plasma levels of glyburide, a CYP2C9 substrate. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
In vitro research shows that Tinospora cordifolia extract inhibits CYP2D6 at high concentrations. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Tinospora cordifolia might reduce the effectiveness of immunosuppressants.
In vitro and animal research shows that Tinospora cordifolia has immunostimulant effects.

Likelihood Possible Evidence D
Guduchi full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Liver Care, from the product label.

Exir USA

See all Exir USA products
Name
Epicure Garden
Phone Number
1-888-381-0106
Web Address
www.exirsaffron.com
Pharmacist Counseling Corner

Liver Care by Exir USA: Common Questions

Does Liver Care by Exir USA interact with any medications?
Yes. Based on its ingredients, Liver Care has a known interaction with 612 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Liver Care contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually help the liver?
The ingredients are traditional Ayurvedic botanicals chosen for liver support, but we don't have clinical evidence data on file showing how well this specific combination works for liver health. Guduchi has evidence for blood sugar control in diabetes, not liver disease. Talk with your doctor if you have liver concerns and want to know whether this product is right for you.
Can I take it if I'm pregnant or breastfeeding?
No. Safety has not been established in pregnancy, so it is best avoided. There is not enough reliable safety information for breastfeeding either, so avoid use while nursing. Talk with your doctor or pharmacist about safer options if you're in either situation.
What are the side effects?
Most people tolerate guduchi well. The most common side effects in trials are headache and nasal pain. Rare but serious liver injury has been reported in case series — some patients developed acute or autoimmune hepatitis after 42–90 days of use. If you have existing liver problems, use this product carefully and under guidance, and watch for yellowing of skin or eyes, dark urine, or unusual tiredness.
Is this safe if I take diabetes medication?
Guduchi can lower blood glucose on its own. Taking it with diabetes drugs raises the theoretical risk of low blood sugar (hypoglycemia). Talk with your doctor or pharmacist before combining this product with any diabetes medication.
What is guduchi?
Guduchi (Tinospora cordifolia) is a traditional herb used in Ayurvedic medicine to support liver and immune function. Clinical research shows it can reduce blood glucose, but it also has documented theoretical interactions with how your liver clears certain medications.
What are the other ingredients?
Phyllanthus, bringaraj, tephrosia purpurea, and nirgundi are traditional Ayurvedic botanicals grouped in the proprietary blend for liver support. We hold no interaction data for these ingredients, so we cannot check their safety with your medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Liver Care label
Go deeper

The Full Monographs Behind Liver Care’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tinospora Cordifolia

Interacts with 612 drugs

Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat fevers. Early laboratory and small human studies s...

Read the full Tinospora Cordifolia monograph →
Sources

Sources & How We Checked

Liver Care's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tinospora Cordifolia 16 references
  1. Stanely Mainzen Prince P, Menon VP. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res 2003;17:410-3.
  2. Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461-70. PubMed
  3. Manjrekar PN, Jolly CI, Narayanan S. Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000;71:254-7. PubMed
  4. Prince PS, Menon VP. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J Ethnopharmacol 1999;65:277-81. PubMed
  5. Stanely Mainzen Prince P, Menon VP, Gunasekaran G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol 1999;64:53-7. PubMed
  6. Badar VA, Thawani VR, Wakode PT, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol 2005;96:445-9. PubMed
  7. Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997;58:89-95. PubMed
  8. Nair PK, Rodriguez S, Ramachandran R, et al. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int Immunopharmacol 2004;4:1645-59. PubMed
  9. Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF. Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial. J Pharmacol Pharmacother. 2 PubMed
  10. Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. PubMed
  11. Patial V, Katoch S, Chhimwal J, Singh PP, Suresh PS, Padwad Y. Tinospora cordifolia activates PPAR? pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease. Phytomedicine 2021;91:153663. PubMed
  12. Kulkarni AV, Hanchanale P, Prakash V, et al. Tinospora Cordifolia (Giloy)-Induced Liver Injury During the COVID-19 Pandemic-Multicenter Nationwide Study From India. Hepatol Commun 2022;6(6):1289-1300. PubMed
  13. Nagral A, Adhyaru K, Rudra OS, Gharat A, Bhandare S. Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series. J Clin Exp Hepatol. 2021;11(6):732-738. PubMed
  14. Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
  15. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed
  16. May K, Jeitler M, Murthy V, Stapelfeldt E, Kessler CS. A Case Report of Acute Hepatitis Involving the Medicinal Herb Tinospora cordifolia Along with Other Variables. J Integr Complement Med 2023;29(5):327-333.

See these in context on the Tinospora Cordifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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