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Dietary supplement

Saffron Extract Ingredients & Drug Interactions

by Lake Avenue Nutrition

Saffron Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Saffron Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Saffron Extract is a dietary supplement by Lake Avenue Nutrition with 1 active ingredient. Its ingredients are commonly taken for depression and low mood, anxiety, pms symptoms.Based on those ingredients, 521 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Saffron Stigma Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Saffron Extract by Lake Avenue Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Saffron Extract by Lake Avenue Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Saffron Extract by Lake Avenue Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Saffron Stigma Extract. Saffron is the dried stigma (the female reproductive part) of the saffron crocus flower, traditionally used in cooking and folk medicine.

The inactive ingredients — magnesium stearate, modified cellulose, and silicon dioxide — are fillers and capsule materials that help hold the supplement together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Saffron's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: stress management support.
  • We looked for evidence on: Anxiety, Postpartum depression, Premenstrual syndrome (PMS), Premenstrual dysphoric disorder (PMDD), depression, mood — and 1 related terms.
  • The closest evidence on file: Saffron is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Saffron is rated "Insufficient Reliable Evidence To Rate" for Postpartum depression, Premenstrual dysphoric disorder (PMDD), Premenstrual syndrome (PMS).

Saffron extract is rated possibly effective for chemotherapy-induced peripheral neuropathy (nerve pain caused by cancer drugs) and for Alzheimer disease based on the data we hold. This means there's some promising clinical evidence, but more research is needed before we can say how well it works in practice.

For other uses, the evidence isn't established in our data.

The evidence, ingredient by ingredient Saffron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saffron extract is generally well tolerated when taken by mouth. The most common side effects are gastrointestinal complaints, nausea, sedation, and vomiting.

Rare but serious reactions include anaphylaxis (a severe allergic reaction). Some people have reported anxiety and mood changes at higher doses.

Because saffron may stimulate the uterus, the safety data advises against medicinal or supplement amounts during pregnancy. For breastfeeding, there isn't enough reliable safety information — talk with your doctor or pharmacist about whether it's right for you.

Side effects, ingredient by ingredient Saffron

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saffron.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 521 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this supplement, double-check with your doctor or pharmacist if you take CNS depressants (sleep aids, anxiety medications, opioids, or anything that makes you drowsy), blood pressure medications, diabetes medications, or consume significant caffeine. Saffron has documented Moderate-severity interactions with all of these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Saffron extract may help with nerve pain from chemotherapy or Alzheimer disease symptoms, but the evidence is still developing. If you take blood pressure medications, diabetes drugs, sleep aids, anxiety medications, or consume a lot of caffeine, you'll want to check with your doctor or pharmacist first — saffron can interact with all of these.

Pregnant people should avoid it. It's generally well tolerated, but gastrointestinal side effects and sedation do occur.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Saffron Extract, straight from the product label.

Brand Lake Avenue Nutrition
Barcode (UPC) 898220018789
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 272670
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Saffron Extract by Lake Avenue Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
898220018789
IngredientAmount% DV
Saffron Stigma Extract88.5 mg--

Other ingredients: Magnesium Stearate, Modified Cellulose, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule daily with food, or as recommended by a healthcare practitioner.

Formulation

Formulated without: GMOs, gluten or soy.

Stress management support

Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, or gluten.

Precautions

Warnings: Keep out of reach of children.

As with all dietary supplements, it is recommended to consult with a healthcare professional before adding something new to your health and wellness regimen. Sealed for your protection, do not use if seal is missing or broken.

Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, or gluten. Produced in a third-party, GMP facility that may process other products that contain these allergens or ingredients.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Lake Avenue Nutrition is a registered trademark of Madre Labs, LLC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Saffron Extract by Lake Avenue Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Saffron Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Saffron Extract by Lake Avenue Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Saffron Stigma Extract

Interacts with
521 drugs
88.5 mg per serving Form: Crocus sativus Stigma Extract

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research us...

Saffron Stigma Extract monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Modified Cellulose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Saffron Extract by Lake Avenue Nutrition Drug Interactions

Want to check YOUR meds against Saffron Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
521Drugs
521 Moderate

Ingredients driving the most interactions

Saffron Stigma Extract 521

Individual Drug Interactions

The ingredients in Saffron Extract interact with 521 drugs. Click any drug to see the details.

1 of the 1 ingredient in Saffron Extract interact with drugs. Each result below shows which ingredient is responsible. Saffron Stigma Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Saffron Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saffron Stigma Extract4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Saffron Stigma Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Saffron Extract, from the product label.

Lake Avenue Nutrition

See all Lake Avenue Nutrition products
Name
Madre Labs, LLC
Street Address
301 N. Lake Ave., Ste. 600
City
Pasadena
State
CA
ZipCode
91101
Web Address
LakeAvenueNutrition.com
Pharmacist Counseling Corner

Saffron Extract by Lake Avenue Nutrition: Common Questions

Does Saffron Extract by Lake Avenue Nutrition interact with any medications?
Yes. Based on its ingredients, Saffron Extract has a known interaction with 521 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Saffron Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No — the safety data advises against medicinal or supplement amounts of saffron during pregnancy because it may stimulate the uterus. Talk with your doctor or pharmacist if you're pregnant or planning to become pregnant.
Can I take this if I'm breastfeeding?
There isn't enough reliable safety information to know either way. Talk with your doctor or pharmacist to decide whether it's right for you.
What are the most common side effects?
Gastrointestinal complaints, nausea, sedation, and vomiting. Most people tolerate saffron extract well, but these effects do occur in some users.
Will this make me drowsy?
Clinical research shows that saffron extract at 60 mg daily can cause drowsiness and sedation. If you're sensitive to sedating effects or take medications that make you drowsy, this is especially important to discuss with your doctor or pharmacist.
What is saffron extract supposed to help with?
Based on our data, saffron extract is possibly effective for chemotherapy-induced peripheral neuropathy (nerve pain from cancer drugs) and Alzheimer disease. The evidence is promising but still developing.
Is this safe at high doses?
No — saffron is likely safe in food amounts, but supplement doses should be used carefully because high doses can be toxic. Stick to the dose on the label and talk with your pharmacist if you're unsure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Saffron Extract label
Go deeper

The Full Monographs Behind Saffron Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph →
Sources

Sources & How We Checked

Saffron Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saffron 22 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Feo F, Martinez J, Martinez A, et al. Occupational allergy in saffron workers. Allergy 1997;52:633-41. PubMed
  5. Wuthrich B, Schmid-Grendelmeyer P, Lundberg M. Anaphylaxis to saffron. Allergy 1997;52:476-7. PubMed
  6. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 2005;19:148-51.
  7. Safarinejad MR, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasth
  8. Fatehi, M., Rashidabady, T., and Fatehi-Hassanabad, Z. Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J Ethnopharmacol. 2003; PubMed
  9. Modaghegh, M. H., Shahabian, M., Esmaeili, H. A., Rajbai, O., and Hosseinzadeh, H. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine. 2008;15(12):1032-1037. PubMed
  10. Imenshahidi, M., Hosseinzadeh, H., and Javadpour, Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother.Res 12-9-2009;
  11. Zhang, Y., Shoyama, Y., Sugiura, M., and Saito, H. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol.Pharm Bull. 1994;17(2):217-221. PubMed
  12. Wuthrich, B., Schmid-Grendelmeyer, P., and Lundberg, M. Anaphylaxis to saffron. Allergy 1997;52(4):476-477. PubMed
  13. Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and plac
  14. Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, Foroughifar T, Salimi S, Akhondzadeh S. Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial. Ph PubMed
  15. Kianbakht S, Ghazavi A. Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial. Phytother Res. 2011 Dec;25(12):1801-5. PubMed
  16. Mazidi M, Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Mokhber N, Ghayour-Mobarhan M, Ferns GA. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J C
  17. Safarinejad MR, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment. Int J Impo PubMed
  18. Talaei A, Hassanpour Moghadam M, Sajadi Tabassi SA, Mohajeri SA. Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial. J Affect Disord. 2 PubMed
  19. Azimi P, Ghiasvand R Feizi A, Hariri M, Abbasi B. Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes. Rev Diabet Stud. 2014 Fall-Winter;11(3-4
  20. Begas E, Bounitsi M, Kilindris T, et al. Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers. Food Chem Toxicol. 2019;130:32-43. PubMed
  21. Moravej Aleali A, Amani R, Shahbazian H, Namjooyan F, Latifi SM, Cheraghian B. The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabet
  22. Abbaszadeh-Mashkani S, Hoque SS, Banafshe HR, Ghaderi A. The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment. Phytother Res. 2021; PubMed

See these in context on the Saffron monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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