Major interaction on record — check this product against your medications before combining. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

Once-Daily Health Booster Ingredients & Drug Interactions

by Life Extension

Once-Daily Health Booster label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Once-Daily Health Booster against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Once-Daily Health Booster is a dietary supplement by Life Extension with 8 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 1,261 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin E, Saffron Stigma Extract, Chlorophyllin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Once-Daily Health Booster by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Once-Daily Health Booster by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Once-Daily Health Booster by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 10 of its 12 active ingredients.
  • “Blend” is a proprietary blend — the label gives one combined amount (4 mg) without saying how much of each component you get.
  • “Trans-Zeaxanthin” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “MacuGuard Proprietary Blend” is a proprietary blend — the label gives one combined amount (173 mg) without saying how much of each component you get.

Once-Daily Health Booster contains 12 active ingredients spanning vitamins, plant pigments, and botanical extracts. Vitamin E and mixed tocotrienols are fat-soluble antioxidants; vitamin K1 and K2 support blood clotting and bone health.

Lutein, lycopene, and zeaxanthin (trans and meso) are carotenoids — plant pigments that concentrate in the eye and may support vision. Alpha-carotene is another carotenoid we could not fully check.

Saffron stigma extract and chlorophyllin are botanical and semi-synthetic compounds included for their potential health effects. Phospholipids are fatty compounds we have no interaction data for.

The product also contains inactive ingredients — flaxseed oil, gelatin, glycerin, safflower oil, corn oil, beeswax, palm oil, silica, acacia gum, carob, microcrystalline cellulose, soybean oil, maltodextrin, and purified water — which serve as fillers, oils, and capsule materials.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Hemorrhagic disease — rated "Effective" (Vitamin K) (Natural Medicines).
  • On file: Hypoprothrombinemia — rated "Effective" (Vitamin K) (Natural Medicines).
  • On file: Vitamin E deficiency — rated "Effective" (Vitamin E) (Natural Medicines).
  • On file: Warfarin anticoagulation — rated "Effective" (Vitamin K) (Natural Medicines).
  • On file: Ataxia with vitamin E deficiency (AVED) — rated "Effective" (Vitamin E) (Natural Medicines).

The evidence for effectiveness varies by ingredient and condition. Vitamin E is effective for treating vitamin E deficiency and AVED (ataxia with vitamin E deficiency); it's possibly effective for Alzheimer disease, beta-thalassemia, G6PD deficiency, and preventing intracranial hemorrhage.

The vitamin K vitamins are effective for correcting clotting-factor deficiencies and hemorrhagic disease, and possibly effective for osteoporosis. Lutein and zeaxanthin are possibly effective for age-related macular degeneration (AMD) but possibly ineffective for retinitis pigmentosa and several other eye and lung conditions.

Lycopene is possibly effective for prostate cancer but rated as having insufficient evidence for diabetes, high cholesterol, and ALS. Saffron extract is possibly effective for chemotherapy-related nerve pain and Alzheimer disease.

Chlorophyllin and alpha-carotene lack established evidence for their claimed uses in this product.

The evidence, ingredient by ingredient Vitamin E Lycopene Calendula Chlorophyllin Saffron Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E is generally well tolerated at dietary amounts, but high-dose long-term supplements raise the risk of bleeding and, in rare cases, hemorrhagic stroke or cardiovascular problems — caution is especially important if you take blood thinners or have vitamin K deficiency. Vitamin K (K1 and K2) is generally well tolerated; common side effects from oral use are mild and include nausea, stomach upset, and diarrhea.

Lutein and lycopene are generally well tolerated; lycopene may cause gastrointestinal effects like diarrhea or nausea. Zeaxanthin is generally well tolerated.

Saffron is well tolerated at typical doses but can cause drowsiness, nausea, and gastrointestinal effects; high doses can be toxic, and anaphylaxis is rare. Chlorophyllin has limited long-term safety data and may cause photosensitivity or blistering reactions in some people.

For pregnancy, vitamin K is likely safe; vitamin E and zeaxanthin are likely safe but warrant discussion with your doctor; lutein is likely safe; lycopene, saffron, and chlorophyllin lack sufficient safety data and should be discussed with your doctor before use. For breastfeeding, vitamin K and lutein are likely safe; vitamin E requires caution at high doses; zeaxanthin, lycopene, saffron, and chlorophyllin lack sufficient data — speak with your provider.

Side effects, ingredient by ingredient Vitamin E Lycopene Calendula Chlorophyllin Saffron Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Lycopene, Chlorophyllin, Saffron, Vitamin E, Vitamin K, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 1,262 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Warfarin (and other blood thinners like apixaban, rivaroxaban, dabigatran): vitamin K1, K2, and vitamin E all increase bleeding risk or reduce warfarin's effectiveness. Chemotherapy drugs (especially alkylating agents and antitumor antibiotics): vitamin E may reduce their effectiveness.

Blood pressure medications: saffron may lower blood pressure further. Diabetes medications: saffron and zeaxanthin may increase hypoglycemia risk.

Liver-processed medications (CYP3A4 substrates): vitamin E may speed their metabolism. Photosensitizing drugs: chlorophyllin may add to photosensitivity.

Cyclosporine: a specific form of vitamin E may increase its levels. Niacin: vitamin E may reduce its cholesterol benefits.

Caffeine: saffron may alter its metabolism.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This product is designed to support eye health and general antioxidant status with a blend of vitamins and plant pigments. If you take warfarin or any other blood thinner, check with your pharmacist before starting — vitamin K can interfere with warfarin, and vitamin E increases bleeding risk.

If you're on chemotherapy, have diabetes, take blood pressure or diabetes medications, or use photosensitizing drugs, run your exact medications through our interaction checker. Pregnant or breastfeeding?

Talk to your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Once-Daily Health Booster, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870229162
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 328605
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Once-Daily Health Booster by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
737870229162
IngredientAmount% DV
Vitamin E30.2 mg201%
Blend4 mg--
Vitamin K11500 mcg--
Vitamin K21000 mcg--
Lutein10 mg--
Lycopene10 mg--
Phospholipids0 NP--
Trans-Zeaxanthin0 NP--
Meso-Zeaxanthin0 NP--
MacuGuard Proprietary Blend173 mg--
Alpha-Carotene1.24 mg--
Mixed Tocotrienols55 mg--
Marigold Flower Extract0 NP--
Chlorophyllin100 mg--
Saffron Stigma Extract20 mg--
Vitamin K2100 mcg--
Vitamin K Activity2600 mcg2167%

Other ingredients: Flaxseed Oil, Gelatin, Glycerin, Safflower Oil, Corn Oil, Water, Purified, Beeswax, Palm Oil, Silica, Acacia Gum, Carob, Microcrystalline Cellulose, Soybean Oil, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Precautions

Read the entire label and follow the directions carefully.

Caution: If you are taking a vitamin K antagonist (e.g. warfarin), consult your healthcare practitioner before taking this product.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is damaged.

Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) softgel daily, with food, or as recommended by a healthcare practitioner.

1 daily

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

LuteinPlus and Mz are registered trademarks of NutriProducts Ltd., UK, licensed under U.S. Patent 8,623,428

Formulation

Gluten free Non GMO Le certified

Seals/Symbols

Non GMO Le certified

Formula

Get the health benefits of fat-soluble vitamins and phytonutrients

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Once-Daily Health Booster by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Once-Daily Health Booster label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Once-Daily Health Booster by Life Extension

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
764 drugs
30.2 mg per serving Form: D-Alpha-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Lycopene

Interacts with
122 drugs
10 mg per serving Form: Tomato fruit extract

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

MacuGuard Proprietary Blend

173 mg per serving

Mixed Tocotrienols

Interacts with
764 drugs
55 mg per serving

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Mixed Tocotrienols monograph & interactions

Chlorophyllin

Interacts with
335 drugs
100 mg per serving Form: Sodium Magnesium Chlorophyllin

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing....

Chlorophyllin monograph & interactions

Saffron Stigma Extract

Interacts with
521 drugs
20 mg per serving

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research us...

Saffron Stigma Extract monograph & interactions

Vitamin K Activity

Interacts with
2 drugs
2600 mcg per serving

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K Activity monograph & interactions

Other (inactive) ingredients: Flaxseed Oil, Gelatin, Glycerin, Safflower Oil, Corn Oil, Water, Purified, Beeswax, Palm Oil, Silica, Acacia Gum, Carob, Microcrystalline Cellulose, Soybean Oil, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Once-Daily Health Booster by Life Extension Drug Interactions

Want to check YOUR meds against Once-Daily Health Booster?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,261Drugs
2 Major 1,258 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin E 764
Saffron Stigma Extract 521
Chlorophyllin 335
Marigold Flower Extract 248
Lycopene 122

Individual Drug Interactions

The ingredients in Once-Daily Health Booster interact with 1,261 drugs. Click any drug to see the details.

6 of the 8 ingredients in Once-Daily Health Booster interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Saffron Stigma Extract Chlorophyllin Marigold Flower Extract Lycopene Vitamin K Activity

Each ingredient & the kinds of drugs it affects

For each ingredient in Once-Daily Health Booster with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Saffron Stigma Extract4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Saffron Stigma Extract full monograph & interactions

Chlorophyllin1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.

Likelihood Probable Evidence B
Chlorophyllin full monograph & interactions

Marigold Flower Extract1 drug type · 248 drugs

Cns Depressants

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Although some animal research has suggested that a saponoside constituent in calendula may have sedative effects, calendula has been used for over 30 years without reports of sedation in humans.

Likelihood Unlikely Evidence D
Marigold Flower Extract full monograph & interactions

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions

Vitamin K Activity1 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K Activity full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Once-Daily Health Booster, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Once-Daily Health Booster by Life Extension: Common Questions

Does Once-Daily Health Booster by Life Extension interact with any medications?
Yes. Based on its ingredients, Once-Daily Health Booster has a known interaction with 1,261 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Once-Daily Health Booster contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm taking warfarin?
Not without checking with your pharmacist first. This product contains vitamin K1, K2, and vitamin E — all of which can interfere with warfarin's blood-thinning effect. Vitamin K can reverse warfarin's benefits, and vitamin E increases bleeding risk. Talk to your pharmacist before taking it.
Can I take this if I'm on chemotherapy?
Check with your oncologist. The vitamin E in this product may theoretically reduce the effectiveness of certain chemotherapy drugs that rely on free radicals to work, like alkylating agents and antitumor antibiotics. Your doctor needs to know you're considering it.
What is saffron in here supposed to do?
Saffron stigma extract is included for its possible effectiveness in chemotherapy-related nerve pain and Alzheimer disease. It's generally well tolerated in typical supplement doses, though it can cause drowsiness, nausea, or gastrointestinal upset.
Is this safe during pregnancy?
Some ingredients are likely safe — vitamin K and lutein — but others lack sufficient pregnancy safety data, including saffron and chlorophyllin. Talk with your doctor before taking this during pregnancy for personalized advice.
What do lutein and lycopene do?
Lutein and lycopene are plant pigments. Lutein is possibly effective for age-related macular degeneration and cataracts. Lycopene is possibly effective for prostate cancer support but has insufficient evidence for diabetes and high cholesterol.
Does this have any fillers?
Yes. Besides the active ingredients, the softgel contains flaxseed oil, gelatin, glycerin, safflower oil, corn oil, beeswax, palm oil, silica, acacia gum, carob, microcrystalline cellulose, soybean oil, maltodextrin, and purified water as inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Once-Daily Health Booster is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Once-Daily Health Booster label
Go deeper

The Full Monographs Behind Once-Daily Health Booster’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph → Herb & supplement monograph

Calendula

Interacts with 248 drugs

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing. Some early research is promising for ski...

Read the full Calendula monograph → Herb & supplement monograph

Chlorophyllin

Interacts with 335 drugs

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a d...

Read the full Chlorophyllin monograph → Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph → Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Once-Daily Health Booster's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 128 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
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Vitamin K 11 references
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Lutein 2 references
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Lycopene 10 references
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Zeaxanthin 4 references
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Calendula 9 references
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Chlorophyllin 6 references
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Saffron 22 references
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  17. Safarinejad MR, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment. Int J Impo PubMed
  18. Talaei A, Hassanpour Moghadam M, Sajadi Tabassi SA, Mohajeri SA. Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial. J Affect Disord. 2 PubMed
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