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Dietary supplement

Sarsaparilla 2,000 mg Ingredients & Drug Interactions

by Nature's Answer

Sarsaparilla 2,000 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sarsaparilla 2,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sarsaparilla 2,000 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for skin conditions like psoriasis, joint pain and arthritis, general tonic or 'blood purifier'.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sarsaparilla (Smilax sp.) root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sarsaparilla 2,000 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Sarsaparilla 2,000 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sarsaparilla 2,000 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: sarsaparilla (Smilax sp.) root extract at 2,000 mg per dose. The extract is delivered in a liquid base of purified water, vegetable glycerin, and certified organic alcohol (12–15%).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Sarsaparilla product and its label doesn't state a use — see Sarsaparilla's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence on sarsaparilla for cancer, psoriasis, and rheumatoid arthritis is insufficient to rate it — we don't have reliable data showing whether it works for these uses. If you're considering it for one of these conditions, the science hasn't established that it does.

The evidence, ingredient by ingredient Sarsaparilla

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sarsaparilla in food amounts appears to carry low risk, but human safety data for supplement doses are limited. Occupational exposure to sarsaparilla root dust can trigger rhinitis and asthma symptoms, though this is mainly a concern for people handling the raw material.

The safety data advise against use during pregnancy and breastfeeding because there isn't enough information to know whether it's safe. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Sarsaparilla

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sarsaparilla.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take lithium or digoxin (Lanoxin). Both interactions are rated Moderate, and sarsaparilla's diuretic properties may change how your body processes these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sarsaparilla may interest you if you're exploring herbal options, but evidence for its effectiveness isn't established. If you take lithium or digoxin, check with your doctor or pharmacist before starting — this product may affect how your body handles these medications.

A conversation with your own healthcare provider will help you decide whether it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sarsaparilla 2,000 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000004872
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD May 22, 2016
DSLD ID 59313
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sarsaparilla 2,000 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
15
UPC/BARCODE
083000004872
IngredientAmount% DV
Sarsaparilla (Smilax sp.) root extract2000 mg--

Other ingredients: purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Gluten Free

K Parve

Bio-Chelated Cold Extraction Process

Formula

K Parve

Smilax sp.

Low Alcohol

General

9291 Rev. 515 1139

General Statements

Since 1972

Super Concentrated 2,000 mg

Our facility is cGMP certified, organic and kosher certified.

Brand IP Statement(s)

Advanced Botanical Fingerprint

Discover Nature's Answer

Our organic alcohol extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

2015 Nature's Answer

Formulation

Gluten-Free

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1-2 mL (28-56 drops) three (3) times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sarsaparilla 2,000 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sarsaparilla 2,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sarsaparilla 2,000 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Sarsaparilla (Smilax sp.) root extract

Interacts with
2 drugs
2000 mg per serving

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...

Sarsaparilla (Smilax sp.) root extract monograph & interactions

Other (inactive) ingredients: Purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sarsaparilla 2,000 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Sarsaparilla 2,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Sarsaparilla (Smilax sp.) root extract 2

Individual Drug Interactions

The ingredients in Sarsaparilla 2,000 mg interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sarsaparilla 2,000 mg interact with drugs. Each result below shows which ingredient is responsible. Sarsaparilla (Smilax sp.) root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sarsaparilla 2,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sarsaparilla (Smilax sp.) root extract2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Sarsaparilla (Smilax sp.) root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sarsaparilla 2,000 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
City
Hauppauge
State
NY
ZipCode
11788-3943
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Sarsaparilla 2,000 mg by Nature's Answer: Common Questions

Does Sarsaparilla 2,000 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Sarsaparilla 2,000 mg has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sarsaparilla 2,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does sarsaparilla actually work for any of these conditions?
The evidence we hold is insufficient to say. For cancer, psoriasis, and rheumatoid arthritis, reliable data on sarsaparilla's effectiveness haven't been established. If you're considering it for one of these, talk with your doctor about what the current science shows.
Is this product safe to take?
In food amounts, sarsaparilla appears to carry low risk. But human safety data for supplement doses at this strength are limited, so we can't make a full safety claim. Talk with your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or taking other medications.
Can I take this if I'm pregnant or breastfeeding?
The safety data advise against it — there isn't enough information to know whether it's safe in either case. If you're pregnant, planning to become pregnant, or breastfeeding, check with your doctor or pharmacist first.
What's in the liquid base?
The product contains purified water, vegetable glycerin, and certified organic alcohol (12–15%). The alcohol content is part of the extract delivery system.
Can this interact with my heart medications?
If you take digoxin (Lanoxin), yes — there's a documented Moderate interaction. Sarsaparilla's diuretic properties may cause potassium loss, which can increase the risk of heart toxicity with digoxin. Confirm with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sarsaparilla 2,000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sarsaparilla 2,000 mg label
Go deeper

The Full Monographs Behind Sarsaparilla 2,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph →
Sources

Sources & How We Checked

Sarsaparilla 2,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sarsaparilla 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed

See these in context on the Sarsaparilla monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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