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Dietary supplement

Sarsaparilla Ingredients & Drug Interactions

by Hawaii Pharm

Sarsaparilla label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sarsaparilla against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sarsaparilla is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for skin conditions like psoriasis, joint pain and arthritis, general tonic or 'blood purifier'.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Sarsaparilla extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sarsaparilla by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Sarsaparilla by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sarsaparilla by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: certified organic sarsaparilla extract. The extract is delivered in a liquid form using vegetable palm glycerin and pharmaceutical-grade alcohol as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Sarsaparilla product and its label doesn't state a use — see Sarsaparilla's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for sarsaparilla's effectiveness isn't established in our data. We hold insufficient reliable evidence to rate it for cancer, psoriasis, or rheumatoid arthritis.

If you're considering it for a specific condition, talk with your doctor or pharmacist about what the research actually supports.

The evidence, ingredient by ingredient Sarsaparilla

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sarsaparilla is likely low-risk in food amounts, but human safety data for supplement doses are limited. Occupational exposure to sarsaparilla root dust can trigger rhinitis and asthma symptoms in some people.

The safety data advises against use during pregnancy and while breastfeeding due to insufficient information.

Side effects, ingredient by ingredient Sarsaparilla

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sarsaparilla.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this sarsaparilla liquid, double-check with your doctor or pharmacist if you take digoxin (Lanoxin) for your heart or lithium for mood stability. Both interactions are rated Moderate severity.

No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Hawaii Pharm's Sarsaparilla Liquid is a single-ingredient extract that carries potential interactions with heart and mood medications. If you take digoxin or lithium, or any other prescription medication, check with your doctor or pharmacist before adding this supplement.

Pregnant or breastfeeding individuals should avoid it unless their healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sarsaparilla, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 0787699238807
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Oct 23, 2020
DSLD ID 237594
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sarsaparilla by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
0787699238807
IngredientAmount% DV
certified organic Sarsaparilla extract970 mg--

Other ingredients: Vegetable Palm Glycerin, pharmaceutical grade Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Hawaii Pharm Herbal Extract Highest quality since 2008

Made with Aloha!

Formulation

Contains no GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers.

Super concentrated liquid herbal extract. Dry herb/menstruum ratio: 1:3.

Manufactured in an FDA registered facility.

Non GMO Gluten free

Made in USA, Hawaii

Suggested/Recommended/Usage/Directions

Directions for use: Shake well before using. Take about 20-30 drops (0.7-1 ml, one full squeeze of the dropper bulb) to 2-4 oz of juice or water up to 4 times per day.

Precautions

Warning: Keep out of the reach of children.

May have contraindications. We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing or taking any medications.

Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

Formula

(Smilax medica)

FDA Statement of Identity

Herbal Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

FDA Registered Facility Made in United States of America USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sarsaparilla by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sarsaparilla label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sarsaparilla by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Certified organic Sarsaparilla extract

Interacts with
2 drugs
970 mg per serving

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...

Certified organic Sarsaparilla extract monograph & interactions

Other (inactive) ingredients: Vegetable Palm Glycerin, Pharmaceutical grade Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sarsaparilla by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Sarsaparilla?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

certified organic Sarsaparilla extract 2

Individual Drug Interactions

The ingredients in Sarsaparilla interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sarsaparilla interact with drugs. Each result below shows which ingredient is responsible. certified organic Sarsaparilla extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sarsaparilla with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Sarsaparilla extract2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
certified organic Sarsaparilla extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sarsaparilla, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
City
Honolulu
State
HI
ZipCode
96815
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Sarsaparilla by Hawaii Pharm: Common Questions

Does Sarsaparilla by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Sarsaparilla has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sarsaparilla contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this sarsaparilla if I'm on digoxin?
Not without checking with your doctor first. Sarsaparilla's diuretic properties may lower your potassium levels, which combined with digoxin increases the risk of heart toxicity. Your doctor may need to adjust your dose or monitor you more closely.
What about if I take lithium?
You'll want to talk with your doctor before starting. Sarsaparilla may reduce how your body clears lithium, raising its levels and side effects. Your lithium dose might need adjustment.
Is this safe to take during pregnancy?
No. There isn't enough safety information, so it's best avoided during pregnancy. Talk with your doctor or pharmacist if you're pregnant or planning to become pregnant.
Can I take it while breastfeeding?
The safety data advises against it — there's not enough information to know it's safe while breastfeeding. Discuss this with your doctor or pharmacist for personalized advice.
Does sarsaparilla actually work for anything?
The evidence we hold is insufficient to rate it for cancer, psoriasis, or rheumatoid arthritis. If you're thinking of it for a specific health goal, your doctor or pharmacist can help you understand what the research actually shows.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sarsaparilla is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sarsaparilla label
Go deeper

The Full Monographs Behind Sarsaparilla’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph →
Sources

Sources & How We Checked

Sarsaparilla's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sarsaparilla 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed

See these in context on the Sarsaparilla monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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