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Dietary supplement

Sarsaparilla Root 850 mg Ingredients & Drug Interactions

by Nature's Way

Sarsaparilla Root 850 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sarsaparilla Root 850 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sarsaparilla Root 850 mg is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for skin conditions like psoriasis, joint pain and arthritis, general tonic or 'blood purifier'.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sarsaparilla. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sarsaparilla Root 850 mg by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Sarsaparilla Root 850 mg by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sarsaparilla Root 850 mg by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: sarsaparilla root at 850 mg per capsule. Sarsaparilla has been used traditionally and is believed to have diuretic properties — meaning it may increase urine output.

The capsule itself is plant-derived, and the formula also contains magnesium stearate as an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Sarsaparilla product and its label doesn't state a use — see Sarsaparilla's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The data we hold shows insufficient reliable evidence to rate sarsaparilla for cancer, psoriasis, or rheumatoid arthritis. That doesn't mean it doesn't work — it means the research hasn't established its effectiveness for these uses in a way we can confidently report.

If you're considering it for another purpose, talk it over with your doctor.

The evidence, ingredient by ingredient Sarsaparilla

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sarsaparilla is likely low-risk at food amounts, but human safety data for supplement doses like this one are limited. The safety information isn't strong enough to recommend it during pregnancy or while breastfeeding — if you're pregnant, nursing, or planning to be, chat with your doctor or pharmacist before taking it.

Occupational exposure to sarsaparilla root dust can cause nasal inflammation (rhinitis) and asthma symptoms, though that's unlikely from taking a capsule.

Side effects, ingredient by ingredient Sarsaparilla

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sarsaparilla.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this product, double-check with your doctor or pharmacist if you take lithium or digoxin. Both carry Moderate-severity interactions tied to sarsaparilla's diuretic effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sarsaparilla Root may appeal to folks looking to support general wellness, but if you take lithium or digoxin, it's not a good fit without your doctor's say-so. The evidence for specific health conditions isn't established yet.

Check with your own doctor or pharmacist before starting, especially if you're on any heart or mood medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sarsaparilla Root 850 mg, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674167007
Net contents 100 Vegan Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2019
DSLD ID 205157
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sarsaparilla Root 850 mg by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
033674167007
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Sarsaparilla850 mg--

Other ingredients: plant-derived Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Traditional herbal remedy At Nature's Way, we believe nature knows best. That's why our mission is to seek out the best herbs the earth has to give. We will go to any continent or country to find where herbs grow best, so we can bring you the purest botanicals possible. It's the way we deliver uncompromising quality and the way to help you live healthier. It's not just our way, it's Nature's Way.

Quality global sourcing Bottled & tested in the USA

Since 1969

Formulation

Gluten free. No sugar, salt, yeast, wheat, soy, corn, dairy products, or artificial colors, flavors, or preservatives.

Vegan

Non GMO

Seals/Symbols

Vegan

Certified Authentic Tru-ID Non GMO Project Verified Nongmoproject.org

Formula

Sarsaparilla Root 850 mg per Serving

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 2 capsules daily.

Precautions

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

Brand IP Statement(s)

2019 Nature's Way Brands, LLC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sarsaparilla Root 850 mg by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sarsaparilla Root 850 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sarsaparilla Root 850 mg by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Sarsaparilla

Interacts with
2 drugs
850 mg per serving

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...

Sarsaparilla monograph & interactions

Other (inactive) ingredients: Plant-derived Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sarsaparilla Root 850 mg by Nature's Way Drug Interactions

Want to check YOUR meds against Sarsaparilla Root 850 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Sarsaparilla 2

Individual Drug Interactions

The ingredients in Sarsaparilla Root 850 mg interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sarsaparilla Root 850 mg interact with drugs. Each result below shows which ingredient is responsible. Sarsaparilla

Each ingredient & the kinds of drugs it affects

For each ingredient in Sarsaparilla Root 850 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sarsaparilla2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Sarsaparilla full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sarsaparilla Root 850 mg, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Sarsaparilla Root 850 mg by Nature's Way: Common Questions

Does Sarsaparilla Root 850 mg by Nature's Way interact with any medications?
Yes. Based on its ingredients, Sarsaparilla Root 850 mg has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sarsaparilla Root 850 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety information to recommend sarsaparilla during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you.
What is sarsaparilla supposed to do?
Sarsaparilla is believed to have diuretic properties — it may increase urine output. It's been used traditionally for various purposes, but the evidence we have doesn't reliably support its use for cancer, psoriasis, or rheumatoid arthritis.
Are there any side effects from taking this supplement?
Human safety data for supplement doses are limited, so we don't have a clear picture of common side effects. Occupational exposure to sarsaparilla root dust can cause nasal and asthma symptoms, though that's not the same as taking a capsule by mouth.
Why do I need to be careful with lithium or digoxin?
Sarsaparilla acts as a diuretic. With lithium, it may slow the drug's removal from your body, raising lithium levels and side effects. With digoxin, it can lower potassium, which increases your risk of heart problems while on that drug.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sarsaparilla Root 850 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sarsaparilla Root 850 mg label
Go deeper

The Full Monographs Behind Sarsaparilla Root 850 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph →
Sources

Sources & How We Checked

Sarsaparilla Root 850 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sarsaparilla 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed

See these in context on the Sarsaparilla monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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