Sarsaparilla Root 425 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Sarsaparilla Root 425 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sarsaparilla Root 425 mg is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for skin conditions like psoriasis, joint pain and arthritis, general tonic or 'blood purifier'.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sarsaparilla. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sarsaparilla Root 425 mg by The Vitamin Shoppe
Ask about any prescription or over-the-counter medication and we check it for interactions with Sarsaparilla Root 425 mg by The Vitamin Shoppe — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sarsaparilla Root 425 mg by The Vitamin Shoppe
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: sarsaparilla root at 425 mg per capsule. Sarsaparilla is a plant root used traditionally in herbal medicine.
The capsule itself is made from gelatin, microcrystalline cellulose, and magnesium stearate — standard inactive ingredients that form and stabilize the supplement.
Does it work?
Couldn't assess
The evidence for sarsaparilla's effectiveness isn't established in our data. There isn't reliable information available to rate it for cancer, psoriasis, or rheumatoid arthritis (RA).
If you're considering this supplement for a specific condition, talk it over with your doctor about whether the evidence supports its use.
How safe is it?
Well-documented data
Sarsaparilla is likely low-risk at the doses found in food, but human safety data for supplement doses are limited. The data advises against use during pregnancy and while breastfeeding because there isn't enough safety information.
Inhaling sarsaparilla root dust (mainly an occupational concern) can cause rhinitis and asthma symptoms, but oral supplement use at normal doses isn't expected to cause that.
Meds to double-check
Moderate interaction found
Check before taking this product if you're on lithium or digoxin (Lanoxin). Both are Moderate-severity interactions related to sarsaparilla's diuretic effects.
Your doctor or pharmacist can assess whether the combination is safe for you or if dosing adjustments are needed.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Sarsaparilla Root is a single-ingredient herbal supplement with documented interactions with heart and psychiatric medications. If you take lithium or digoxin, you'll want to clear this with your doctor or pharmacist first.
For most other people without those medications, the main question is whether the evidence for your intended use is strong enough — and that's a conversation worth having with your healthcare provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sarsaparilla Root 425 mg, straight from the product label.
| Brand | The Vitamin Shoppe |
|---|---|
| Barcode (UPC) | 766536020522 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2014 |
| DSLD ID | 32604 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sarsaparilla Root 425 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Sarsaparilla | 425 mg | -- |
Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
herb
a traditional herb
{capsule} actual size
This natural product may vary in color.
Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.
{QRC} learn more at vsquality.net
FDA Statement of Identity
dietary supplement
Formulation
gluten free dairy free soy free nut free
Does not contain: Yeast, Corn, Wheat, Gluten, Sugar, Salt, Soy, Starch, Dairy, Citrus, Fish, Preservatives, Artificial Colors or Flavors.
Suggested/Recommended/Usage/Directions
DIRECTIONS: As a dietary supplement, take one (1) to three (3) capsules daily, preferably with meals.
Precautions
WARNING: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.
KEEP OUT OF REACH OF CHILDREN.
TAMPER EVIDENT Do not use if outer seal is broken or missing.
Storage
STORE IN A COOL, DRY PLACE.
General
Item No. VS-2052 1071364 BO 1
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sarsaparilla Root 425 mg by The Vitamin Shoppe label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sarsaparilla Root 425 mg by The Vitamin Shoppe
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Sarsaparilla
Interacts with2 drugs
Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...
Sarsaparilla monograph & interactionsOther (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Sarsaparilla Root 425 mg by The Vitamin Shoppe Drug Interactions
HelloPharmacist Interaction Report
Sarsaparilla Root 425 mg by The Vitamin Shoppe does interact with certain medications — specifically, lithium and digoxin (Lanoxin).
Because sarsaparilla is thought to have diuretic properties (it makes your body shed more fluid), it may reduce how your kidneys clear lithium from your system, raising lithium levels and increasing both its effects and side effects. Your lithium dose might need adjustment.
Read the full breakdown — every affected drug type, severity by severity
Digoxin, a heart medication, carries similar concerns. Diuretic effects can cause potassium loss, and low potassium combined with digoxin therapy increases the risk of heart rhythm problems (cardiac toxicity).
Altogether, these interactions span 2 individual medications. If you take either of these drugs, check with your doctor or pharmacist before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sarsaparilla Root 425 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sarsaparilla Root 425 mg interact with 2 drugs. Click any drug to see the details.
1 of the 1 ingredient in Sarsaparilla Root 425 mg interact with drugs. Each result below shows which ingredient is responsible. Sarsaparilla
DigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Sarsaparilla Root 425 mg — through 1 ingredient. Tap an ingredient for the detail:
SarsaparillaDigoxin (lanoxin) Moderate
Interaction Summary
Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Read the full Sarsaparilla + Digoxin interactionLithium Carbonate (prescription Drug)Eskalith, Lithium Carbonate
How Lithium Carbonate (prescription Drug) interacts with Sarsaparilla Root 425 mg — through 1 ingredient. Tap an ingredient for the detail:
SarsaparillaLithium Moderate
Interaction Summary
Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Read the full Sarsaparilla + Lithium Carbonate (prescription Drug) interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sarsaparilla Root 425 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Sarsaparilla
Digoxin (Lanoxin)
Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.
Lithium
Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Sarsaparilla Root 425 mg, from the product label.
The Vitamin Shoppe
See all The Vitamin Shoppe products- Name
- Vitamin Shoppe, Inc.
- City
- Secaucus
- State
- NJ
- ZipCode
- 07094
- Phone Number
- 1-800-223-1216
- Web Address
- www.vitaminshoppe.com
Sarsaparilla Root 425 mg by The Vitamin Shoppe: Common Questions
Does Sarsaparilla Root 425 mg by The Vitamin Shoppe interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while pregnant or breastfeeding?
Does sarsaparilla actually work for psoriasis or arthritis?
What's the diuretic effect it mentions?
Are there any side effects from taking this supplement itself?
What's in the capsule besides sarsaparilla?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Sarsaparilla Root 425 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sarsaparilla Root 425 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Sarsaparilla Root 425 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sarsaparilla 3 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC