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Dietary supplement

Serrapeptase Enzymes Delayed Release Ingredients & Drug Interactions

by Dr. Mercola

Serrapeptase Enzymes Delayed Release label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase Enzymes Delayed Release against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase Enzymes Delayed Release is a dietary supplement by Dr. Mercola with 2 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase Enzymes Delayed Release by Dr. Mercola

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase Enzymes Delayed Release by Dr. Mercola — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Serrapeptase Enzymes Delayed Release by Dr. Mercola

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.

This product contains 2 active ingredients: serrapeptase and protease. Serrapeptase is a proteolytic enzyme—a protein-digesting enzyme derived from the silkworm—that's thought to break down certain proteins in the body.

Protease is another protein-digesting enzyme used similarly. The delayed-release capsule design is meant to help these enzymes survive stomach acid and reach the small intestine intact.

The inactive ingredients are hydroxypropyl methylcellulose, gellan gum, rice, and medium chain triglyceride (all fillers, binders, or capsule materials).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for serrapeptase is limited. For chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis—conditions this type of supplement is often marketed for—the data we hold shows insufficient reliable evidence to rate whether it works.

Protease effectiveness ratings are not available in our data.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally tolerated in the short term, though long-term safety hasn't been well studied. The most common side effects are epigastric pain (pain in the upper abdomen), gastrointestinal upset, and nausea—and these appear to occur at about the same rate as placebo in trials.

A rare serious side effect, bullous pemphigoid (a blistering skin condition), has been reported. Protease is generally well tolerated for most adults but may occasionally cause digestive upset or allergic reactions.

Rarely, people exposed to airborne protease—such as occupational exposure—have developed allergic rhinoconjunctivitis (hay fever-like symptoms) or asthma. During pregnancy, the safety data for serrapeptase advises against use.

For breastfeeding, serrapeptase has no reliable safety information, so it should be avoided. Protease safety data during pregnancy and breastfeeding are also limited, so medical advice is recommended before use in these periods.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners and antiplatelet drugs are the main concern—serrapeptase may increase bruising and bleeding risk with these medications. If you take warfarin, aspirin, clopidogrel, or any similar drug, check it below before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners or antiplatelet drugs, check this product with your pharmacist or using our tool before starting. If you're pregnant or breastfeeding, talk with your doctor or pharmacist first—safety data is limited for both ingredients.

Otherwise, it's generally tolerated short-term, though evidence for its claimed uses is not yet established.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase Enzymes Delayed Release, straight from the product label.

Brand Dr. Mercola
Barcode (UPC) 810094210915
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 308866
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase Enzymes Delayed Release by Dr. Mercola, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
810094210915
IngredientAmount% DV
Protease0 NP--
Serrapeptase0 NP--

Other ingredients: Hydroxypropyl Methylcellulose, Gellan Gum, Rice, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Adults, as a dietary supplement, take one (1) capsule per serving on an empty stomach. This product can be taken one to two times daily.

Precautions

Keep out of reach of children.

Do not use if safety seal is broken.

If you are nursing, pregnant, have a blood coagulation or other medical condition, or are taking medication such as anticoagulants, consult your physician before taking this product.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Dr. Mercola Providing quality products since 2001.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase Enzymes Delayed Release by Dr. Mercola label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase Enzymes Delayed Release label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase Enzymes Delayed Release by Dr. Mercola

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protease

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Serrapeptase

Interacts with
122 drugs
0 NP per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Gellan Gum, Rice, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase Enzymes Delayed Release by Dr. Mercola Drug Interactions

Want to check YOUR meds against Serrapeptase Enzymes Delayed Release?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase Enzymes Delayed Release interact with 122 drugs. Click any drug to see the details.

1 of the 2 ingredients in Serrapeptase Enzymes Delayed Release interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase Enzymes Delayed Release with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase Enzymes Delayed Release, from the product label.

Dr. Mercola

See all Dr. Mercola products
Name
NHP
Street Address
125 SW 3rd Place
City
Cape Coral
State
FL
ZipCode
33991
Phone Number
(877) 985-2696
Pharmacist Counseling Corner

Serrapeptase Enzymes Delayed Release by Dr. Mercola: Common Questions

Does Serrapeptase Enzymes Delayed Release by Dr. Mercola interact with any medications?
Yes. Based on its ingredients, Serrapeptase Enzymes Delayed Release has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase Enzymes Delayed Release contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Safety data for both serrapeptase and protease are limited during pregnancy and breastfeeding. Serrapeptase specifically should be avoided in pregnancy unless prescribed, and during breastfeeding there's not enough reliable information. Talk with your doctor or pharmacist about whether this product is right for you.
What are the most common side effects?
The most common side effects from serrapeptase are epigastric pain (upper belly pain), gastrointestinal upset, and nausea—but these appear to occur at about the same rate as placebo in trials. Protease may occasionally cause digestive upset or allergic reactions.
Is serrapeptase FDA-approved?
Serrapeptase is sold as a dietary supplement in the US, not as a drug. The FDA does not approve supplements the way it approves medications. Our data shows the evidence for its claimed uses is insufficient to rate at this time.
How long can I take this safely?
Short-term use of serrapeptase is generally tolerated, but long-term safety hasn't been well studied. If you're thinking of taking this regularly for weeks or months, check with your pharmacist or doctor first.
Will this help with my chronic bronchitis (or back pain, asthma)?
The evidence we hold does not establish whether serrapeptase works for chronic bronchitis, asthma, atherosclerosis, back pain, or osteoporosis. If you're considering it for one of these conditions, talk with your doctor about whether it's worth trying and what the realistic expectations are.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase Enzymes Delayed Release label
Go deeper

The Full Monographs Behind Serrapeptase Enzymes Delayed Release’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase Enzymes Delayed Release's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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