Similase Jr Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Similase Jr against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Similase Jr is a dietary supplement by Integrative Therapeutics with 8 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Similase Jr by Integrative Therapeutics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Similase Jr contains 11 active ingredients, all digestive enzymes that help break down different types of food. Lipase breaks down fats, lactase breaks down milk sugar (lactose), and phytase breaks down plant compounds.
The blend also includes amylase and maltase for carbohydrates, protease enzymes for protein, cellulase for plant fiber, and several others — dipeptidyl peptidase-IV, sucrase, endopeptidase, exopeptidase, and peptide hydrolase — that target specific protein and carbohydrate fragments. The capsule itself is made from vegetable material, with cellulose and ascorbyl palmitate (a form of vitamin C) as inactive ingredients.
Does it work?
Strong evidence
The evidence for these enzymes is mixed and often limited. Lactase is considered effective for lactose intolerance — that's its strongest rating.
For the other active ingredients and the conditions they've been studied for — like inflammatory bowel disease (IBD), dyspepsia (indigestion), and various deficiencies — the available evidence is insufficient to rate them reliably. That doesn't mean they don't work; it means good-quality research backing them up isn't yet on file in our data.
How safe is it?
Well-documented data
Lipase, lactase, and phytase are generally well tolerated when used as directed. Lactase has caused rare allergic reactions in people exposed to powdered forms (contact dermatitis and allergic rhinoconjunctivitis), though this risk appears low for oral supplementation.
Phytase exposure in occupational settings has triggered allergic responses like occupational asthma and hypersensitivity pneumonitis, but human supplement safety data are limited. Anyone with serious digestive conditions should use these enzymes only under medical guidance.
For pregnancy, lactase is rated likely safe; lipase and phytase have limited or absent safety data in pregnancy — talk with your doctor before regular use. Breastfeeding safety data are similarly sparse for lipase and phytase — check with your healthcare provider first.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check in Similase Jr. That said, we don't hold interaction data for amylase, cellulase, dipeptidyl peptidase-IV, sucrase, endopeptidase, exopeptidase, maltase, and peptide hydrolase — so if you take any medications, use the search tool on this page to verify your exact drugs.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Similase Jr is a multi-enzyme blend aimed at supporting digestion, with lactase being its best-supported ingredient for lactose intolerance and the others having limited evidence. If you have a serious digestive condition or are pregnant or breastfeeding, talk with your doctor or pharmacist before starting it.
No drug interactions are documented for the ingredients we checked, but several ingredients couldn't be reviewed — run your medications through the checker on this page to be sure.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Similase Jr, straight from the product label.
| Brand | Integrative Therapeutics |
|---|---|
| Barcode (UPC) | 871791001947 |
| Net contents | 90 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Sep 21, 2017 |
| DSLD ID | 78551 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Children (All), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Similase Jr by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Dipeptidyl Peptidase-IV | 0 NP | -- |
| Sucrase | 0 NP | -- |
| Endopeptidase | 0 NP | -- |
| Exopeptidase | 0 NP | -- |
| Maltase | 0 NP | -- |
| Microbial Enzymes | 252 mg | -- |
| Peptide Hydrolase | 0 NP | -- |
Other ingredients: Vegetable Capsule, Cellulose, Ascorbyl Palmitate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Contains no sugar, salt, yeast, wheat, corn, soy, dairy products, artificial colors, flavors, preservatives or ingredients of animal origin.
Brand IP Statement(s)
2015 Distributed by Integrative Therapeutics, LLC
General
LZ106009.B01 B050167B
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formula
Children's digestive enzymes
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommendation: Take 1 or 2 capsules at the beginning of each meal, or as recommended by your healthcare professional.
Precautions
Not recommended for use if peptic ulcer, gastritis or heartburn is present.
If pregnant, nursing, or taking prescription drugs, consult your healthcare professional prior to use.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Similase Jr by Integrative Therapeutics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Similase Jr by Integrative Therapeutics
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Vegetable Capsule, Cellulose, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.
Similase Jr by Integrative Therapeutics Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Similase Jr. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Similase Jr, from the product label.
Integrative Therapeutics
See all Integrative Therapeutics products- Name
- Integrative Therapeutics, LLC
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 800.931.1709
- Web Address
- integrativepro.com
Similase Jr by Integrative Therapeutics: Common Questions
Does Similase Jr by Integrative Therapeutics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is Similase Jr safe to take if I'm pregnant?
Can I take this while breastfeeding?
What is lactase, and why is it in here?
Are there any reported side effects?
Does this product actually work for digestion?
What are the inactive ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Similase Jr is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Similase Jr’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph →Sources & How We Checked
Similase Jr's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC