Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Slim 700 Ingredients & Drug Interactions

by S4L Slim4Life

Slim 700 label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Slim 700 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Slim 700 is a dietary supplement by S4L Slim4Life with 4 active ingredients. Its ingredients are commonly taken for blood sugar support, digestive upset, antioxidant support.Based on those ingredients, 1,007 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema, Cinnamon, Mulberry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Slim 700 by S4L Slim4Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Slim 700 by S4L Slim4Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Slim 700 by S4L Slim4Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (375 mg) without saying how much of each component you get.

Slim 700 contains 4 active ingredients in a proprietary blend: cinnamon, salacia oblonga, mulberry leaf extract, and gymnema. These are combined with inactive ingredients—corn starch, cellulose, stearic acid, magnesium stearate, silicon dioxide, hydroxypropyl-methylcellulose, and riboflavin—that serve as binders and fillers in the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Sugar and starch blocker for carbohydrate control.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Obesity, Dyslipidemia, Metabolic syndrome, postprandial glucose spike — and 2 related terms.
  • The closest evidence on file: Black Mulberry is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Obesity, Impaired glucose tolerance (prediabetes), Metabolic syndrome.
  • Also on file: Cassia Cinnamon is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Dyslipidemia.

The evidence for how well these ingredients work isn't established in our data. For all of them—cinnamon, salacia, mulberry, and gymnema—the available research shows insufficient reliable evidence to confidently rate their effectiveness for diabetes, obesity, blood sugar control, or the other conditions they're marketed for.

That doesn't mean they don't work; it means the clinical trial data we have isn't strong enough to say.

The evidence, ingredient by ingredient Cassia Cinnamon Salacia Black Mulberry Gymnema

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cinnamon is likely safe in the amounts found in food, but supplement doses high in coumarin (a compound in cassia cinnamon) may stress the liver over time; avoid high-dose supplement amounts in pregnancy, and stick to food amounts if you're breastfeeding. Salacia appears generally well tolerated short-term but lacks long-term safety data; it should be avoided in pregnancy and breastfeeding.

Mulberry fruit as food is safe, but concentrated supplement doses are less studied; the fruit is likely fine while nursing, but supplements aren't established as safe. Gymnema is generally well tolerated short-term and can lower blood sugar, but quality varies between products; it should be avoided in pregnancy and breastfeeding.

Rare adverse effects include rash, allergic contact dermatitis from cinnamon, low blood sugar seizures, and in one case, drug-induced hepatitis (liver inflammation) from gymnema tea. Salacia commonly causes stomach upset—abdominal pain, diarrhea, gas, nausea, and bloating—especially at higher doses.

Side effects, ingredient by ingredient Cassia Cinnamon Salacia Black Mulberry Gymnema

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Black Mulberry, Gymnema, Cassia Cinnamon, Salacia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 1,008 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Slim 700, double-check with your doctor or pharmacist if you're on antidiabetes drugs (like metformin, insulin, sulfonylureas, or glinides)—all four ingredients may lower your blood sugar and could cause hypoglycemia. Also flag medications that stress the liver, midazolam or other sedatives, phenacetin, tolbutamide, and any drugs metabolized through the liver enzymes CYP1A2, CYP2C9, or CYP3A4—gymnema and other ingredients in this blend may alter how your body clears them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Slim 700 is built around ingredients that may help with blood sugar and weight, but the clinical evidence for them is limited and not yet strong. If you take diabetes medications, blood pressure drugs, sedatives, or any other prescription, you need to clear this with your doctor or pharmacist first—the interactions are real.

Pregnant or breastfeeding? Skip salacia and gymnema entirely, and talk with your healthcare provider about cinnamon and mulberry at supplement doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Slim 700, straight from the product label.

Brand S4L Slim4Life
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62115
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Slim 700 by S4L Slim4Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
IngredientAmount% DV
Proprietary Blend375 mg--
Cinnamon0 NP--
Salacia oblonga0 NP--
Mulberry0 NP--
Gymnema0 NP--

Other ingredients: Corn Starch, Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Hydroxypropyl-Methylcellulose, Riboflavin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Sugar & starch blocker

Mulberry (Morus alba) leaves contain the substance 1-deoxynojirimycin, and Salacia oblonga contains salacinol and kotanolo. All these substance are inhibitors of alpha-glucosidase, an enzyme that promotes the breakdown of carbohydrates containing alpha-glucoside links between the component sugar molecule. Ingestion of the inhibitors, which also inhibit alpha-amylase, can reduce the digestion of sugars and starches in foods so that less absorbable monosaccharides are formed, thus reducing available caloric content of some foods. Gymnema (Gymnema sylvestre) modulates sugar metabolism and may help reduce cravings for sweet foods by blunting sense of taste for sweetness.

FDA Statement of Identity

Herbal Supplement

General

PLS2307090957V1

Suggested/Recommended/Usage/Directions

Directions: Take one (1) tablet with 8 oz (240 mL) water 10 minutes before meals. Do not exceed a maximum of 4 tablets per day.

Precautions

Do not exceed a maximum of 4 tablets per day. Cautions and Warnings: Use of alpha-amylase and alpha-glucosidase inhibitors can result in quantities of undigested starch and sugars passing int he large intestine, where they may be broken down but gut microflora. This can result in production of gas and occasionally abdominal discomfort. If the product is taken regularly as per instructions, these symptoms generally subside after a few days, because the gut microflora adapts.

Sale to, or use by, persons under the age of 18 must have parent approval. Keep out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Slim 700 by S4L Slim4Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Slim 700 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Slim 700 by S4L Slim4Life

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

375 mg per serving

Other (inactive) ingredients: Corn Starch, Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Hydroxypropyl-Methylcellulose, Riboflavin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Slim 700 by S4L Slim4Life Drug Interactions

Want to check YOUR meds against Slim 700?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,007Drugs
590 Moderate 417 Minor

Ingredients driving the most interactions

Gymnema 851
Cinnamon 442
Mulberry 87
Salacia oblonga 86

Individual Drug Interactions

The ingredients in Slim 700 interact with 1,007 drugs. Click any drug to see the details.

4 of the 4 ingredients in Slim 700 interact with drugs. Each result below shows which ingredient is responsible. Gymnema Cinnamon Mulberry Salacia oblonga

Each ingredient & the kinds of drugs it affects

For each ingredient in Slim 700 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gymnema6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
Gymnema full monograph & interactions

Cinnamon2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon full monograph & interactions

Mulberry2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
One small clinical study shows that black mulberry leaf extract has hypoglycemic effects. This is supported by in vitro research which also suggests that constituents in black mulberry twigs and leaves might have hypoglycemic effects.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, black mulberry might inhibit the metabolism of midazolam.
In vitro research shows that black mulberry juice can inhibit midazolam 1'-hydroxylation, a reaction that is catalyzed by cytochrome P450 3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Mulberry full monograph & interactions

Salacia oblonga1 drug type · 86 drugs

Antidiabetes Drugs

Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research suggests that salacia might lower blood glucose levels.

Likelihood Probable Evidence D
Salacia oblonga full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Slim 700, from the product label.

S4L Slim4Life

See all S4L Slim4Life products
Name
4Life TM Holdings, LLC
Street Address
17470 North Pacesetter Way
City
Scottsdale
State
AZ
ZipCode
85255
Pharmacist Counseling Corner

Slim 700 by S4L Slim4Life: Common Questions

Does Slim 700 by S4L Slim4Life interact with any medications?
Yes. Based on its ingredients, Slim 700 has a known interaction with 1,007 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Slim 700 contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Slim 700 if I'm pregnant or breastfeeding?
Cinnamon at food amounts is likely safe during pregnancy and breastfeeding, but don't use high-dose cinnamon supplements. Salacia and gymnema lack enough safety data—they should be avoided entirely during pregnancy and breastfeeding. Mulberry as fruit is fine, but there isn't reliable safety information for concentrated supplement doses while nursing. Talk with your doctor or pharmacist before taking this product if you're pregnant or breastfeeding.
What stomach side effects might I experience?
Salacia commonly causes gas, bloating, abdominal pain, diarrhea, and nausea, especially at higher doses. These are dose-dependent and happen because undigested carbohydrates ferment in your bowel. If you're sensitive to stomach upset, start low and see how you tolerate it.
Does Slim 700 actually work for weight loss or blood sugar control?
The evidence isn't strong enough to say. For all four active ingredients—cinnamon, salacia, mulberry, and gymnema—we have insufficient reliable evidence to rate how well they work for diabetes, obesity, or prediabetes. That's not a guarantee they don't; it means the clinical trial data we have isn't solid yet.
Can Slim 700 hurt my liver?
Cinnamon in high supplement doses contains coumarin, which may stress the liver with long-term use. Gymnema has one rare case report of drug-induced hepatitis (liver inflammation) in someone who drank gymnema tea heavily for 10 days, though this is unusual. If you have liver disease or take medications that affect the liver, check with your doctor or pharmacist.
Why does the product have so many medication interactions?
Gymnema interacts with many drugs because it can inhibit or speed up liver enzymes (CYP1A2, CYP2C9, CYP3A4) that break down a large number of medications. All four ingredients also share an interaction with diabetes drugs because they all appear to lower blood sugar. The total count spans over 1,000 individual medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Slim 700 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Slim 700 label
Go deeper

The Full Monographs Behind Slim 700’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Salacia

Interacts with 86 drugs

Salacia is a plant used in Ayurvedic medicine, mostly studied for lowering blood sugar after meals. Some small human studies suggest it may modestly blunt blood sugar spikes, but the evidenc...

Read the full Salacia monograph → Herb & supplement monograph

Black Mulberry

Interacts with 87 drugs

Black mulberry is a nutritious fruit rich in antioxidants and vitamins, and it is generally safe to enjoy as a food. Some early research on its leaf and fruit extracts hints at benefits for...

Read the full Black Mulberry monograph → Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph →
Sources

Sources & How We Checked

Slim 700's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 42 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
  17. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
  20. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed

See these in context on the Cassia Cinnamon monograph →

Salacia 5 references
  1. Heacock PM, Hertzler SR, Williams JA, Wolf BW. Effects of a medical food containing an herbal alpha-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults. J Am Diet Assoc 2005;105:65-71.
  2. Collene AL, Hertzler SR, Williams JA, Wolf BW. Effects of a nutritional supplement containing Salacia oblonga extract and insulinogenic amino acids on postprandial glycemia, insulinemia, and breath hydrogen responses in healthy adults. Nutrition 2005;21:8 PubMed
  3. Jayawardena MH, de Alwis NM, Hettigoda V, Fernando DJ. A double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes. J Ethnopharmacol 2005;97:215-8. PubMed
  4. Williams JA, Choe YS, Noss MJ, et al. Extract of Salacia oblonga lowers acute glycemia in patients with type 2 diabetes. Am J Clin Nutr 2007;86:124-30. PubMed
  5. Kajimoto O, Kawamori S, Shimoda H, et al. Effects of a Diet Containing Salacia reticulata on Mild Type 2 Diabetes in Humans. A Placebo-controlled, Cross-over Trial. Nippon Eiyo Shokuryo Gakkaishi 2000;53(5):199-205. DOI

See these in context on the Salacia monograph →

Black Mulberry 5 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Kim, H., Yoon, Y. J., Shon, J. H., Cha, I. J., Shin, J. G., and Liu, K. H. Inhibitory effects of fruit juices on CYP3A activity. Drug Metab Dispos. 2006;34(4):521-523. PubMed
  3. Xu LJ, Yu MH, Huang CY, et al. Isoprenylated flavonoids from Morus nigra and their PPAR ? agonistic activities. Fitoterapia 2018;127:109-14. PubMed
  4. Momeni H, Salehi A, Absalan A, Akbari M. Hydro-alcoholic extract of Morus nigra reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and in silic
  5. Navarro-Triviño FJ, Jadczak P, Llamas-Molina JM, Ruiz-Villaverde R. Lichenoid contact dermatitis caused by Morus nigra L. Contact Dermatitis 2021;84(6):484-486.

See these in context on the Black Mulberry monograph →

Gymnema 12 references
  1. Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
  2. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
  3. Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
  4. Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
  5. Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
  6. Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
  7. Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
  8. Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
  9. Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
  10. Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
  11. Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
  12. Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed

See these in context on the Gymnema monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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