Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Slumberol Ingredients & Drug Interactions

by NutriCology

Slumberol label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Slumberol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Slumberol is a dietary supplement by NutriCology with 4 active ingredients. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and stress, digestive support.Based on those ingredients, 553 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Jujube (fruit) extract, Sacred Lotus (young leaves) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Slumberol by NutriCology

Ask about any prescription or over-the-counter medication and we check it for interactions with Slumberol by NutriCology — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Slumberol by NutriCology

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (3 Gram(s)) without saying how much of each component you get.

Slumberol contains 4 active ingredients in a proprietary blend: jujube (fruit) extract, sacred lotus (young leaves) extract, Sensitive Plant extract, and Sickle-Pod Senna seed extract. Jujube and sacred lotus are traditional ingredients used in sleep and relaxation formulas.

The product also contains inactive ingredients—hydroxypropyl methylcellulose, microcrystalline cellulose, and L-leucine—which are binders and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Sleep support and relaxation.
  • We looked for evidence on: Insomnia, Anxiety, Sleep quality, Restlessness.
  • The closest evidence on file: Zizyphus is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Zizyphus is rated "Insufficient Reliable Evidence To Rate" for Insomnia.
  • Also on file: Lotus is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.

The evidence we hold doesn't establish that jujube or sacred lotus work for any condition, including insomnia. Both show "Insufficient Reliable Evidence To Rate" across all uses in our data, including anxiety and sleep.

That doesn't mean they don't work, only that the research isn't yet solid enough for us to make a claim. We have no effectiveness data for Sensitive Plant or Sickle-Pod Senna.

The evidence, ingredient by ingredient Zizyphus Lotus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Jujube fruit is eaten as food widely, but concentrated supplements haven't been well studied for safety in humans. A small number of people in trials reported headache, diarrhea, or dry mouth.

Sacred lotus is also common as food, but medicinal supplements lack good safety data; one case report described allergic hives and contact dermatitis in a child after lotus root contact. We don't have enough safety information for Sensitive Plant or Sickle-Pod Senna.

The safety data we hold advises against jujube supplements while breastfeeding, and against sacred lotus supplements in pregnancy and breastfeeding.

Side effects, ingredient by ingredient Zizyphus Lotus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Zizyphus, Lotus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 553 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Slumberol, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel)—lotus may increase bleeding risk. Also flag any diabetes medications, CNS depressants (sedatives, sleep aids, anxiety drugs, narcotic painkillers), or pentobarbital (Nembutal).

Additionally, let them know if you drink alcohol regularly, since lotus and jujube may add to its sedative effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Slumberol might appeal to you if you're looking for a plant-based sleep support, but the evidence for it isn't established in our data. It's not suitable if you take blood thinners, diabetes drugs, or strong sedatives without checking first—and anyone with a lotus allergy should avoid it.

Talk with your doctor or pharmacist before starting, especially if you're pregnant, breastfeeding, or taking any medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Slumberol, straight from the product label.

Brand NutriCology
Barcode (UPC) 713947540606
Net contents 100 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 193273
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Slumberol by NutriCology, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
5 Capsule(s)
Servings per container
20
UPC/BARCODE
713947540606
IngredientAmount% DV
Proprietary Blend3 Gram(s)--
Sensitive Plant (leaves) extract0 NP--
Jujube (fruit) extract0 NP--
Sacred Lotus (young leaves) extract0 NP--
Sickle-Pod Senna (seeds) extract0 NP--

Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

A unique proprietary blend of concentrated Chinese herbal extracts, including sensitive plant (Mimosa pudica), jujube (Ziziphus jujuba), sacred lotus (Nelumbo nucifera), and sickle-pod senna (Senna obtusifolia).

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 2 to 5 capsules at bedtime, 1 capsule for daytime relaxation, or as directed by a healthcare practitioner.

Precautions

Warning: May cause drowsiness and should not be taken before driving or operating machinery.

Not labeled for sale in California.

Storage

Keep in a cool, dry place, tightly capped.

General Statements

Innovative Nutrition

Formulation

Hypoallergenic

FDA Statement of Identity

Dietary Supplement

General

Rev. 005

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Slumberol by NutriCology label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Slumberol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Slumberol by NutriCology

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

3 Gram(s) per serving

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Slumberol by NutriCology Drug Interactions

Want to check YOUR meds against Slumberol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
553Drugs
553 Moderate

Ingredients driving the most interactions

Jujube (fruit) extract 469
Sacred Lotus (young leaves) extract 212

Individual Drug Interactions

The ingredients in Slumberol interact with 553 drugs. Click any drug to see the details.

2 of the 4 ingredients in Slumberol interact with drugs. Each result below shows which ingredient is responsible. Jujube (fruit) extract Sacred Lotus (young leaves) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Slumberol with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Jujube (fruit) extract3 drug types · 469 drugs

Antidiabetes Drugs

Theoretically, zizyphus might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that zizyphus has hypoglycemic activity. However, a small clinical study shows that zizyphus fruit powder does not reduce fasting blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Some animal research has found that various parts of zizyphus have sedative effects. However, other animal research shows that zizyphus plant extract does not alter sleep parameters when used in combination with pentobarbital.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Animal research shows that zizyphus induces CYP1A2 enzymes. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Jujube (fruit) extract full monograph & interactions

Sacred Lotus (young leaves) extract3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concurrent use of lotus with other antiplatelet drugs might reduce platelet aggregation and increase the risk of bleeding.
Neferine and isoliensinine, constituents of lotus, have been shown to inhibit platelet aggregation, in vitro. These constituents can inhibit the production of pro-aggregating factors like prostaglandins.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lotus might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Animal research shows that the ethanolic extract of lotus reduces blood glucose levels and potentiates the effects of injected insulin. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, taking lotus concomitantly with pentobarbital might increase sedation.
Animal research shows that lotus extract increases pentobarbitone-induced sleeping time. It is not known if this occurs in humans or if this effect occurs with other barbiturates or sedatives.

Likelihood Possible Evidence D
Sacred Lotus (young leaves) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Slumberol, from the product label.

NutriCology

See all NutriCology products
Name
NutriCology
City
Alameda
State
CA
ZipCode
94502
Phone Number
510.263.2000
Web Address
www.nutricology.com
Pharmacist Counseling Corner

Slumberol by NutriCology: Common Questions

Does Slumberol by NutriCology interact with any medications?
Yes. Based on its ingredients, Slumberol has a known interaction with 553 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Slumberol contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Slumberol if I'm pregnant?
The data we hold rates jujube as "Likely Safe" in pregnancy, but we don't have a pregnancy rating for sacred lotus—the safety data advises against it. Since this is a blend and we can't check all ingredients, talk with your doctor or pharmacist for personalized guidance before starting.
Can I take Slumberol while breastfeeding?
No. The safety data advises against both jujube and sacred lotus supplements while breastfeeding because there isn't enough information to know they're safe. Talk with your doctor or pharmacist about alternatives if you're nursing.
What side effects might I notice?
In small clinical trials, jujube was linked to headache, diarrhea, and dry mouth; lotus was associated with allergic hives or contact dermatitis, especially if you're sensitive to it. Most people who use these plants as food don't report problems, but concentrated supplements are less well studied.
Does this actually help with sleep?
We don't have reliable evidence that jujube or sacred lotus improve insomnia. Both ingredients show "Insufficient Reliable Evidence To Rate" for sleep support in our data, so we can't claim they work for that purpose.
What's in the proprietary blend?
The label lists jujube (fruit) extract, sacred lotus (young leaves) extract, Sensitive Plant extract, and Sickle-Pod Senna seed extract, but the exact amounts of each aren't disclosed—that's typical of proprietary blends.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Slumberol label
Go deeper

The Full Monographs Behind Slumberol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zizyphus

Interacts with 469 drugs

Zizyphus (jujube) is an edible fruit and traditional remedy used mainly for sleep, anxiety, and digestion. The fruit is a nutritious food, but human evidence for its medicinal benefits is li...

Read the full Zizyphus monograph → Herb & supplement monograph

Lotus

Interacts with 212 drugs

Lotus is an edible aquatic plant used in food and traditional medicine across Asia, with parts like the seeds, leaves, and flowers taken for digestion, calm, and overall wellness. Most healt...

Read the full Lotus monograph →
Sources

Sources & How We Checked

Slumberol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zizyphus 15 references
  1. Adzu, B., Amos, S., Dzarma, S., Wambebe, C., and Gamaniel, K. Effect of Zizyphus spina-christi Willd aqueous extract on the central nervous system in mice. J Ethnopharmacol. 2002;79(1):13-16.
  2. Cisse, A., Ndiaye, A., Lopez-Sall, P., Seck, F., Faye, B., and Faye, B. [Antidiabetic activity of Zizyphus mauritiana Lam (Rhamnaceae)]. Dakar Med 2000;45(2):105-107.
  3. Abdel-Zaher, A. O., Salim, S. Y., Assaf, M. H., and Abdel-Hady, R. H. Antidiabetic activity and toxicity of Zizyphus spina-christi leaves. J Ethnopharmacol. 10-3-2005;101(1-3):129-138. PubMed
  4. Nesseem, D. I., Michel, C. G., Sleem, A. A., and El-Alfy, T. S. Formulation and evaluation of antihyperglycemic leaf extracts of Zizyphus spina-christi (L.) Willd. Pharmazie 2009;64(2):104-109. DOI
  5. Anand, K. K., Singh, B., Chand, D., Chandan, B. K., and Gupta, V. N. Effect of Zizyphus sativa leaves on blood glucose levels in normal and alloxan-diabetic rats. J Ethnopharmacol. 1989;27(1-2):121-127. PubMed
  6. Morishita, S., Mishima, Y., Hirai, Y., Saito, T., and Shoji, M. Pharmacological studies of water extract of the Zizyphus seed and the Zizyphus seed containing drug. Gen Pharmacol 1987;18(6):637-641. PubMed
  7. Watanabe, I., Saito, H., and Takagi, K. Pharmacological studies of Zizyphus seeds. Jpn J Pharmacol 1973;23(4):563-571. DOI
  8. Wu, S. X., Zhang, J. X., Xu, T., Li, L. F., Zhao, S. Y., and Lan, M. Y. [Effects of seeds, leaves and fruits of Ziziphus spinosa and jujuboside A on central nervous system function]. Zhongguo Zhong Yao Za Zhi 1993;18(11):685-4.
  9. Glombitza, K. W., Mahran, G. H., Mirhom, Y. W., Michel, K. G., and Motawi, T. K. Hypoglycemic and antihyperglycemic effects of Zizyphus spina-christi in rats. Planta Med 1994;60(3):244-247.
  10. Jarald, E. E., Joshi, S. B., and Jain, D. C. Antidiabetic activity of extracts and fraction of <it>Zizyphus mauritiana. Pharmaceutical Biology 2009;47:328-334.
  11. Ebrahimimd S, Ashkani-Esfahani S, Poormahmudibs A. Investigating the efficacy of zizyphus jujuba on neonatal jaundice. Iran J Pediatr. 2011 Sep;21(3):320-4.
  12. Hajhashemi V, Safaei A. Hypnotic effect of Coriandrum sativum, Ziziphus jujuba, Lavandula angustifolia and Melissa officinalis extracts in mice. Res Pharm Sci. 2015 Nov-Dec;10(6):477-84.
  13. Jing XY, Peng YR, Wang XM, Duan JA. Effects of Ziziphus jujuba fruit extracts on cytochrome P450 (CYP1A2) activity in rats. Chin J Nat Med. 2015 Aug;13(8):588-94. PubMed
  14. Irannejad Niri Z, Shidfar F, Jabbari M, et al. The effect of dried Ziziphus vulgaris on glycemic control, lipid profile, apo-proteins and hs-CRP in patients with type 2 diabetes mellitus: a randomized controlled clinical trial. J Food Biochem 2020; Mar 30
  15. Shergis JL, Hyde A, Meaklim H, Varma P, Da Costa C, Jackson ML. Medicinal seeds Ziziphus spinosa for insomnia: a randomized, placebo-controlled, cross-over, feasibility clinical trial. Complement Ther Med 2021;57:102657. PubMed

See these in context on the Zizyphus monograph →

Lotus 5 references
  1. Yu, J. and Hu, W. S. [Effects of neferine on platelet aggregation in rabbits]. Yao Xue.Xue.Bao. 1997;32(1):1-4.
  2. Yang, J. and Zhou, K. NMR spectroscopic analysis of neferine and isoliensinine. Magn Reson.Chem 2004;42(11):994-997. PubMed
  3. Mukherjee, P. K., Saha, K., Balasubramanian, R., Pal, M., and Saha, B. P. Studies on psychopharmacological effects of Nelumbo nucifera Gaertn. rhizome extract. J Ethnopharmacol. 1996;54(2-3):63-67. PubMed
  4. Mukherjee, P. K., Saha, K., Pal, M., and Saha, B. P. Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats. J Ethnopharmacol. 1997;58(3):207-213. PubMed
  5. Hiraguchi Y, Tokuda R, Gen M, et al. Identification of a novel food allergen in lotus root. Allergol Int. 2018;67(1):141-143. PubMed

See these in context on the Lotus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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