Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Small Intestine Detox Ingredients & Drug Interactions

by Nature's Sunshine

Small Intestine Detox label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Small Intestine Detox against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Small Intestine Detox is a dietary supplement by Nature's Sunshine with 2 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 2,040 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Marshmallow. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Small Intestine Detox by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Small Intestine Detox by Nature's Sunshine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Small Intestine Detox by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (840 mg) without saying how much of each component you get.

This product contains 2 active ingredients: pepsin and marshmallow, packaged in a capsule. Pepsin is a proteolytic enzyme (a protein-digesting enzyme) — the body naturally makes it to break down food in the stomach.

Marshmallow is a plant extract that has been used traditionally for digestive and skin support, though the evidence for its effectiveness is limited.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive system support and intestinal cleansing.
  • We looked for evidence on: intestinal health, bowel function, digestive wellness, gastrointestinal cleansing.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold does not establish that marshmallow is effective for any of the conditions it's been studied for — including diarrhea, skin problems like eczema, respiratory infections, or vaginal yeast infections. All ratings are insufficient reliable evidence.

We also have no established effectiveness data for pepsin in this product.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Marshmallow

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pepsin is generally well tolerated in adults but may cause digestive upset or allergic reactions in some people. Rarely, occupational exposure to airborne pepsin has caused allergic rhinitis or asthma; dietary supplements pose a much lower risk.

Marshmallow is generally well tolerated for short-term use, though long-term human safety data are limited. During pregnancy, marshmallow safety has not been established and is best avoided unless your doctor prescribes it.

Pepsin safety in pregnancy also has not been established — talk with your doctor or pharmacist for personalized guidance. While breastfeeding, marshmallow should not be used without medical advice due to insufficient data; the same applies to pepsin.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Marshmallow

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Marshmallow.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 2,041 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your doctor or pharmacist if you take lithium — marshmallow might raise your lithium levels dangerously. Also flag any oral medications (a spacing rule applies) and any blood thinners or antiplatelet drugs, which may be affected by marshmallow's properties.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Small Intestine Detox may appeal to people seeking digestive support, but the evidence for its active ingredients is not yet established. If you take lithium, oral medications, or blood thinners, you'll want to discuss this product with your doctor or pharmacist before starting — the marshmallow content carries real interaction risks that may need adjustment to your regimen.

Pregnancy and breastfeeding are times to check with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Small Intestine Detox, straight from the product label.

Brand Nature's Sunshine
Barcode (UPC) 099904008489
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 278212
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Small Intestine Detox by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
099904008489
IngredientAmount% DV
Proprietary Blend840 mg--
Pepsin0 NP--
Marshmallow0 NP--

Other ingredients: Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Bottle made from 100% post consumer recycled material. We are committed to you and our planet. Scan to learn more.

We source the world's purest ingredients, no matter where they are grown, to ensure the active nutrients are delivered just as nature intended.

New look! Same great product

Precautions

Contains milk.

Formulation

Digestive system support Traditionally used for intestinal cleansing

Guaranteed pure

FDA Statement of Identity

Dietary Support

Suggested/Recommended/Usage/Directions

Recommended use: Take 2 capsules with a meal three times daily.

Brand IP Statement(s)

Natures Sunshine Herbal experts since 1972

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Small Intestine Detox by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Small Intestine Detox label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Small Intestine Detox by Nature's Sunshine

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

840 mg per serving

Other (inactive) ingredients: Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Small Intestine Detox by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Small Intestine Detox?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,040Drugs
1 Moderate 2,039 Minor

Ingredients driving the most interactions

Marshmallow 2,040

Individual Drug Interactions

The ingredients in Small Intestine Detox interact with 2,040 drugs. Click any drug to see the details.

1 of the 2 ingredients in Small Intestine Detox interact with drugs. Each result below shows which ingredient is responsible. Marshmallow

Each ingredient & the kinds of drugs it affects

For each ingredient in Small Intestine Detox with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Marshmallow3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Marshmallow full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Small Intestine Detox, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc.
City
Spanish Fork
State
UT
ZipCode
84660
Phone Number
(800) 223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Small Intestine Detox by Nature's Sunshine: Common Questions

Does Small Intestine Detox by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Small Intestine Detox has a known interaction with 2,040 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Small Intestine Detox contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does pepsin actually help digestion?
Pepsin is an enzyme your stomach makes naturally to break down protein — it's a real part of digestion. However, we don't have effectiveness data on file for pepsin as a supplement ingredient, so we can't say whether adding it helps beyond what your body already does.
Can I take this if I'm pregnant or breastfeeding?
The safety data for both marshmallow and pepsin in pregnancy and breastfeeding are too limited to recommend use. Talk with your doctor or pharmacist before taking this product if you're pregnant or nursing — they can weigh the unknowns for your situation.
What are the side effects?
Pepsin may cause digestive upset or allergic reactions in some people. Marshmallow is generally well tolerated short-term, though long-term human safety data are limited. In rare cases, exposure to pepsin dust has caused allergic rhinitis or asthma, but dietary supplements pose much lower risk.
I take blood thinners — is this safe?
Marshmallow flower has theoretical antiplatelet effects, which raises a minor concern. However, most marshmallow supplements use the root and leaf, not the flower, so the risk is lower — but it's still worth confirming with your doctor or pharmacist before you start.
I'm on oral medications. Does this interfere?
Yes, potentially. Marshmallow contains mucilage that can reduce how well your body absorbs oral drugs. To avoid this, space this supplement 30–60 minutes away from your other medications. Your pharmacist can help you find the right timing for your specific drugs.
What exactly is in this product?
Small Intestine Detox contains pepsin (a digestive enzyme) and marshmallow extract, plus an inactive capsule. The product has a proprietary blend, meaning the exact amounts of each ingredient aren't listed separately on the label.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Small Intestine Detox is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Small Intestine Detox label
Go deeper

The Full Monographs Behind Small Intestine Detox’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Marshmallow

Interacts with 2,040 drugs

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...

Read the full Marshmallow monograph →
Sources

Sources & How We Checked

Small Intestine Detox's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Marshmallow 5 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Hage-Sleiman R, Mroueh M, Daher CF. Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharm Biol 2011;49(3):327-33.

See these in context on the Marshmallow monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team