Smilax Supreme Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Smilax Supreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Smilax Supreme is a dietary supplement by Supreme Nutrition with 1 active ingredient. Its ingredients are commonly taken for skin conditions like psoriasis, joint pain and arthritis, general tonic or 'blood purifier'.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Smilax officinalis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Smilax Supreme by Supreme Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with Smilax Supreme by Supreme Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Smilax Supreme by Supreme Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Smilax Supreme contains one active ingredient: Smilax officinalis, commonly called sarsaparilla. This is the whole formulation — no fillers or other inactive ingredients are included.
Does it work?
Couldn't assess
The evidence for sarsaparilla is not established in our data. We hold insufficient reliable evidence to rate it for cancer, psoriasis, or rheumatoid arthritis — the three uses shown in our records.
If you're considering this product for a specific condition, talk with your pharmacist or doctor about what the science actually supports.
How safe is it?
Well-documented data
Sarsaparilla appears to be low-risk at food doses, but human safety data for supplement-strength doses are limited, so use caution. The safety information we hold advises against use during pregnancy and breastfeeding due to insufficient data — there isn't enough evidence to know whether it's safe at those times.
Occupational exposure to sarsaparilla root dust can trigger rhinitis and asthma symptoms, though this is mainly a workplace concern rather than a consumer supplement risk.
Meds to double-check
Moderate interaction found
Before you start Smilax Supreme, double-check whether you take lithium or digoxin (Lanoxin). Both are affected by sarsaparilla, and both changes are Moderate in severity.
Use the medication checker on this page to confirm your exact drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Smilax Supreme is a single-ingredient sarsaparilla supplement. If you take lithium or digoxin, check with your pharmacist before starting — this product could affect how those drugs work.
For other people, the main question is whether the evidence supports its use for your goal; talk that through with your pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Smilax Supreme, straight from the product label.
| Brand | Supreme Nutrition |
|---|---|
| Net contents | 90 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 24, 2017 |
| DSLD ID | 73681 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | No Claim |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Smilax Supreme by Supreme Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Smilax officinalis | 460 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Smilax Supreme is packaged in a bottle containing 90 veggie capsules, each containing approximately 460 mg of Smilax officinalis without fillers, binders or excipients.
Formulation
Smilax Supreme is packaged in a bottle containing 90 veggie capsules, each containing approximately 460 mg of Smilax officinalis without fillers, binders or excipients.
General Statements
Smilax Supreme comes from the root of the plant Smilax officinalis which is a small vine that grows throughout Central and South America. This herb has been used for centuries for many purposes. Over the years it has been traditionally prescribed for the following conditions: psoriasis, arthritis, autoimmune diseases, detoxification, hormone regulation, and as a general tonic and blood purifier. It has historically been used to treat syphilis, gonorrhea, and other STD’s since at least the early 1800’s as well as for leptospirosis. Back in 1942 the New England Journal of Medicine reported on Smilax’s effectiveness in treating psoriasis. Psoriasis as well as many other diseases such as inflammatory bowel disease, various liver disorders, pancreatitis, periodontal disease, coronary artery disease, arthritis and asthma are believed to have endotoxins as a possible causative component according to many researchers. One of the main components of Smilax is sarsaponin which has been found to be an effective endotoxin binder which is very possibly the reason it has been so helpful in treating psoriasis as well as so many other symptoms/conditions. Since endotoxins can alter the manufacture of cytokines and eicosanoids, endotoxins can be very pro-inflammatory and have a vast number of effects, mostly negative. Other components of Smilax, specifically some of the flavinoids have been shown to be hepato-protective. We see Smilax filling an important niche in our work. Many alternative medicine physicians find that many of our chronic patients suffer from a variety of sub-clinical “infections” of bacterial, fungal, parasitic, viral, and spirochete origins. These “infections” can cause many symptoms effecting the derma, gastro-intestinal tract, respiratory system, etc. etc. Many of the symptoms can arise from the endotoxins, mycotoxins, etc. produced by these microbes. An herb with the potential to bind many of these toxins can be of much benefit to speed up resolution of the patients complaints. We already know of a number of natural plants that have strong anti-microbial properties but few that are noted for their endotoxin and possibly mycotoxin binding properties. As with most of our products, we test this on most if not all patients. It may show up initially or it also may not show up until dysbiosis is resolved so the body can focus more on endotoxin reduction. We see its greatest uses as: 1) A endotoxin binder and potentially a mycotoxin binder to accompany the antimicrobials you prescribe. 2) As a broad spectrum antimicrobial itself, including as a possible anti-spirochete agent (borrelia, babsesia, etc.) While the research hasn’t been done yet, its effects in treating syphilis suggest its possible usage for other spirochetes as well. 3) Immune modulator especially in people with suspected auto-immune responses. 4) It has been traditionally used to increase libido and hormone balancing so you might want to investigate it in those areas. 5) It is also theorized that it increases GI absorption of other herbs and acts as an aid to the bioavailability of
Country of manufacture: United States
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Smilax Supreme by Supreme Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Smilax Supreme by Supreme Nutrition
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0 Not Present Dosage formCapsule Amounts shown are per serving.
Smilax officinalis
Interacts with2 drugs
Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...
Smilax officinalis monograph & interactionsSmilax Supreme by Supreme Nutrition Drug Interactions
HelloPharmacist Interaction Report
Smilax Supreme by Supreme Nutrition does interact with a small number of medications, both at Moderate severity.
Read the full breakdown — every affected drug type, severity by severity
The main concern is lithium (used for mood disorders). Sarsaparilla, the product's single ingredient, has diuretic properties — it makes you urinate more — and may reduce how your body clears lithium.
That could raise lithium levels in your blood and increase both its effects and side effects. If you take lithium, your dose might need adjustment.
Digoxin (Lanoxin), a heart medication, is also affected. Sarsaparilla's diuretic action can lower potassium levels, and low potassium combined with digoxin raises the risk of heart rhythm problems (cardiac toxicity).
Altogether, these interactions span 2 individual medications. Use the medication checker below to see if you take either of these drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Smilax Supreme?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Smilax Supreme interact with 2 drugs. Click any drug to see the details.
1 of the 1 ingredient in Smilax Supreme interact with drugs. Each result below shows which ingredient is responsible. Smilax officinalis
DigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Smilax Supreme — through 1 ingredient. Tap an ingredient for the detail:
Smilax OfficinalisDigoxin (lanoxin) Moderate
Interaction Summary
Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Read the full Smilax Officinalis + Digoxin interactionLithium Carbonate (prescription Drug)Eskalith, Lithium Carbonate
How Lithium Carbonate (prescription Drug) interacts with Smilax Supreme — through 1 ingredient. Tap an ingredient for the detail:
Smilax OfficinalisLithium Moderate
Interaction Summary
Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Read the full Smilax Officinalis + Lithium Carbonate (prescription Drug) interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Smilax Supreme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Smilax officinalis
Digoxin (Lanoxin)
Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.
Lithium
Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Smilax Supreme, from the product label.
Smilax Supreme by Supreme Nutrition: Common Questions
Does Smilax Supreme by Supreme Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Smilax Supreme if I'm pregnant or breastfeeding?
Does sarsaparilla actually work for arthritis or psoriasis?
Are there any side effects from taking sarsaparilla?
What does sarsaparilla do in the body?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Smilax Supreme is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Smilax Supreme’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Smilax Supreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sarsaparilla 3 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC