Soursop Guanabana Extract Powder 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Soursop Guanabana Extract Powder 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Soursop Guanabana Extract Powder 500 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guanabana Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Soursop Guanabana Extract Powder 500 mg by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Soursop Guanabana Extract Powder 500 mg by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Soursop Guanabana Extract Powder 500 mg by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: guanabana fruit extract, supplied at 500 mg per serving. Guanabana (also called soursop) is a tropical fruit.
The powder also includes dextrin, an inactive ingredient used as a filler.
Does it work?
Couldn't assess
The evidence for guanabana's effectiveness isn't established in the data we hold. Studies have looked at it for human papillomavirus (HPV), headache, insect repellent use, and male fertility, but the evidence is insufficient to rate it for any of those purposes.
We simply don't have reliable human data to say whether it works.
How safe is it?
Well-documented data
Regular use of guanabana raises some safety concerns. The most common side effects from oral use are stomach pain and nausea.
Rarely, long-term use has been linked to movement disorders and nerve damage (myeloneuropathy) — symptoms similar to Parkinson disease. One clinical trial found that patients taking guanabana leaf extract 300 mg daily reported nausea and burning stomach pain.
Because human safety data are limited and lab studies raise concerns about possible nerve toxicity with long-term use, caution is warranted with regular consumption. The safety data advises against use during pregnancy and breastfeeding.
There isn't enough information to know whether it's safe while nursing, so you should talk with your doctor or pharmacist before use if you're pregnant or breastfeeding.
Meds to double-check
Moderate interaction found
If you take carbamazepine (Tegretol) or any seizure medication, double-check with your pharmacist before using this product — guanabana extract may lower carbamazepine levels and make the drug less effective.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you take carbamazepine or any seizure medication, check with your pharmacist before starting this product — the extract may lower drug levels and reduce seizure control. Regular use carries some risk of stomach upset and rare movement or nerve problems.
Pregnant and nursing people should avoid it. Talk to your pharmacist if you have questions about whether this supplement fits your health picture.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Soursop Guanabana Extract Powder 500 mg, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X001EYKMWX |
| Net contents | 1 Kilogram(s); 35.3 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Apr 24, 2025 |
| DSLD ID | 330977 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Soursop Guanabana Extract Powder 500 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
BulkSupplements.com Clean & pure bulk supplements
Formula
Guanabana Extract 500 mg per serving
Formulation
Color may vary
Free of: Added sugar, soy, dairy, yeast, gluten
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 500 mg (about 1/5 tsp) one to three times daily, or as directed by a physician.
General Statements
Use an accurate milligram scale. New
Storage
Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Soursop Guanabana Extract Powder 500 mg by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Soursop Guanabana Extract Powder 500 mg by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 Milligram(s) Dosage formPowder Servings per container2000 Amounts shown are per serving.
Guanabana Fruit Extract
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Guanabana Fruit Extract monograph & interactionsOther (inactive) ingredients: Dextrin. These complete the product’s ingredient list but are not active constituents.
Soursop Guanabana Extract Powder 500 mg by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
Soursop Guanabana Extract Powder by BulkSupplements.com has one documented interaction with a seizure medication.
Guanabana fruit extract may decrease levels of carbamazepine (Tegretol), a drug used to prevent seizures. In animal studies, the extract reduced carbamazepine levels by up to 46%, which could make the medication less effective at controlling seizures.
Read the full breakdown — every affected drug type, severity by severity
No other medication interactions are documented in our data for this ingredient. That doesn't mean none exist — it just means we have no monograph data on file for interactions beyond carbamazepine.
If you take any prescription medications, especially seizure drugs, run them through the checker below before you start this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Soursop Guanabana Extract Powder 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Soursop Guanabana Extract Powder 500 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Soursop Guanabana Extract Powder 500 mg interact with drugs. Each result below shows which ingredient is responsible. Guanabana Fruit Extract
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Soursop Guanabana Extract Powder 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Guanabana Fruit ExtractCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Guanabana Fruit Extract + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Soursop Guanabana Extract Powder 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Guanabana Fruit Extract
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Soursop Guanabana Extract Powder 500 mg, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
Soursop Guanabana Extract Powder 500 mg by BulkSupplements.com: Common Questions
Does Soursop Guanabana Extract Powder 500 mg by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does guanabana work for HPV or headaches?
What are the most common side effects?
Is it safe to use while pregnant or breastfeeding?
What's in the powder besides the guanabana extract?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Soursop Guanabana Extract Powder 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Soursop Guanabana Extract Powder 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Soursop Guanabana Extract Powder 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC