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Dietary supplement

Spearmint Leaf 450 mg Ingredients & Drug Interactions

by TerraVita Premium Collection

Spearmint Leaf 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Spearmint Leaf 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Spearmint Leaf 450 mg is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, nausea, hormonal acne and unwanted hair (pcos-related).Based on those ingredients, 581 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Spearmint. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Spearmint Leaf 450 mg by TerraVita Premium Collection

Ask about any prescription or over-the-counter medication and we check it for interactions with Spearmint Leaf 450 mg by TerraVita Premium Collection — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Spearmint Leaf 450 mg by TerraVita Premium Collection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: spearmint leaf at 450 mg per capsule. It's a straightforward product with just spearmint as the therapeutic component.

The capsule itself is made from gelatin and water, which are inactive ingredients that hold the spearmint together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Spearmint product and its label doesn't state a use — see Spearmint's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that spearmint is effective for any of the uses it's commonly marketed for — age-related thinking problems, general cognitive function, gas, IBS symptoms, nausea after surgery, or osteoarthritis all carry an insufficient evidence rating. That doesn't mean it doesn't work; it means the reliable human research isn't there yet.

If you're considering it for one of these reasons, that's worth discussing with your doctor.

The evidence, ingredient by ingredient Spearmint

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, spearmint is generally well tolerated when taken as a supplement. The main caution is that we have limited reliable data on the safety of concentrated supplements at the doses people typically take — food amounts and tea are safer bets.

Allergic reactions are possible (allergic dermatitis from topical contact, swelling of soft tissues from oral use, or oral lichen planus in sensitive people), though they're uncommon. One person in a clinical trial reported anxiety after taking 600 mg daily of spearmint extract, though it's unclear whether spearmint caused it.

Side effects, ingredient by ingredient Spearmint

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Spearmint.
  • The most serious interaction on file is rated Moderate.
  • For scale: 582 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any hepatotoxic drugs (medications that can affect liver function) with your doctor or pharmacist — spearmint may increase the risk of liver damage when combined with them. Also confirm any CNS depressants (sedating medications, sleeping pills, or anxiety drugs) aren't affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Spearmint Leaf may be worth considering if you're interested in a traditional herb and you don't take medications that interact with it — especially anything affecting your liver or used for sedation. If you take any prescription medication, check it against the interaction tool on this page before you start.

Talk it over with your doctor or pharmacist, particularly if you have liver disease or take sedating drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Spearmint Leaf 450 mg, straight from the product label.

Brand TerraVita Premium Collection
Barcode (UPC) 064435116033
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 286550
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Spearmint Leaf 450 mg by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
064435116033
IngredientAmount% DV
Spearmint450 mg--

Other ingredients: Gelatin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Copyright 2004 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Suggested/Recommended/Usage/Directions

Directions Take 1 capsule, 3 times daily, with meals.

General Statements

TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.

Please recycle!

FDA Disclaimer Statement

Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Spearmint Leaf 450 mg by TerraVita Premium Collection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Spearmint Leaf 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Spearmint Leaf 450 mg by TerraVita Premium Collection

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Spearmint

Interacts with
581 drugs
450 mg per serving

Spearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild horm...

Spearmint monograph & interactions

Other (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Spearmint Leaf 450 mg by TerraVita Premium Collection Drug Interactions

Want to check YOUR meds against Spearmint Leaf 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
581Drugs
581 Moderate

Ingredients driving the most interactions

Spearmint 581

Individual Drug Interactions

The ingredients in Spearmint Leaf 450 mg interact with 581 drugs. Click any drug to see the details.

1 of the 1 ingredient in Spearmint Leaf 450 mg interact with drugs. Each result below shows which ingredient is responsible. Spearmint

Each ingredient & the kinds of drugs it affects

For each ingredient in Spearmint Leaf 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Spearmint2 drug types · 581 drugs

Cns Depressants

Theoretically, spearmint might alter the sedative effects of CNS depressants.
Animal research suggests that (-)-carvone, a major constituent of spearmint, has sedative effects. However, in humans, chewing spearmint-flavored gum induced arousal effects.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Animal research suggests that drinking spearmint tea for 30 days can increase markers of liver damage, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and cause liver degeneration and necrosis, in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Spearmint full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Spearmint Leaf 450 mg, from the product label.

TerraVita Premium Collection

See all TerraVita Premium Collection products
Name
TerraVita Fine Whole Herbs
City
Brampton
State
Ontario
Pharmacist Counseling Corner

Spearmint Leaf 450 mg by TerraVita Premium Collection: Common Questions

Does Spearmint Leaf 450 mg by TerraVita Premium Collection interact with any medications?
Yes. Based on its ingredients, Spearmint Leaf 450 mg has a known interaction with 581 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Spearmint Leaf 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is spearmint safe to take if I'm pregnant or breastfeeding?
The safety data is mixed. Pregnancy ratings show it's both likely safe and possibly unsafe — that contradiction means the evidence is uncertain, and you'll need to talk with your doctor or pharmacist about whether it's right for you. For breastfeeding, it's rated likely safe, but again, check with your own healthcare provider for personalized advice.
Can I get allergic reactions from this supplement?
Yes, though allergies are uncommon. Spearmint can cause allergic dermatitis (skin rashes from topical contact), swelling of the soft tissues in your mouth if you take it orally, and in rare cases, oral lichen planus (a painful condition on the tongue, lips, or palate). If you've had spearmint allergies before, avoid this product.
What is spearmint actually used for in this supplement?
Spearmint is marketed for cognitive decline, IBS, gas, nausea after surgery, osteoarthritis, and general brain function. However, we don't hold reliable evidence that it works for any of these uses.
Will this supplement make me drowsy?
Animal research suggests spearmint has sedative properties, but human studies are unclear — one study with spearmint-flavored gum actually showed arousal, not drowsiness. It may theoretically interact with sedating medications and alter how they work, so if you take sleeping pills or anxiety drugs, check with your pharmacist first.
Is there any concern about my liver with this supplement?
Animal research suggests high doses of spearmint tea can raise liver enzyme markers and cause liver damage. We don't have reliable human studies at the supplement dose you're taking, so if you have liver disease or take medications that affect your liver, ask your doctor before starting.
What are the inactive ingredients in this capsule?
The capsule contains gelatin and water — both are fillers and binders that hold the spearmint leaf together and have no therapeutic role.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Spearmint Leaf 450 mg label
Go deeper

The Full Monographs Behind Spearmint Leaf 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Spearmint

Interacts with 581 drugs

Spearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild hormone-related issues (such as excess facia...

Read the full Spearmint monograph →
Sources

Sources & How We Checked

Spearmint Leaf 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Spearmint 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Akdogan M, Ozguner M, Aydin G, Gokalp O. Investigation of biochemical and histopathological effects of Mentha piperita Labiatae and Mentha spicata Labiatae on liver tissue in rats. Hum Exp Toxicol 2004;23:21-8.
  3. Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. PubMed
  4. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  5. de Sousa, D. P., Farias Nobrega, F. F., and de Almeida, R. N. Influence of the chirality of (R)-(-)- and (S)-(+)-carvone in the central nervous system: a comparative study. Chirality 5-5-2007;19(4):264-268.
  6. Larsen, W., Nakayama, H., Fischer, T., Elsner, P., Frosch, P., Burrows, D., Jordan, W., Shaw, S., Wilkinson, J., Marks, J., Jr., Sugawara, M., Nethercott, M., and Nethercott, J. Fragrance contact dermatitis: a worldwide multicenter investigation (Part II PubMed
  7. Guney, M., Oral, B., Karahanli, N., Mungan, T., and Akdogan, M. The effect of Mentha spicata Labiatae on uterine tissue in rats. Toxicol.Ind.Health 2006;22(8):343-348.
  8. Masumoto, Y., Morinushi, T., Kawasaki, H., Ogura, T., and Takigawa, M. Effects of three principal constituents in chewing gum on electroencephalographic activity. Psychiatry Clin.Neurosci. 1999;53(1):17-23. PubMed
  9. Bulat, R., Fachnie, E., Chauhan, U., Chen, Y., and Tougas, G. Lack of effect of spearmint on lower oesophageal sphincter function and acid reflux in healthy volunteers. Aliment.Pharmacol Ther. 1999;13(6):805-812. PubMed
  10. Francalanci, S., Sertoli, A., Giorgini, S., Pigatto, P., Santucci, B., and Valsecchi, R. Multicentre study of allergic contact cheilitis from toothpastes. Contact Dermatitis 2000;43(4):216-222. PubMed
  11. Bonamonte, D., Mundo, L., Daddabbo, M., and Foti, C. Allergic contact dermatitis from Mentha spicata (spearmint). Contact Dermatitis 2001;45(5):298.
  12. Tomson, N., Murdoch, S., and Finch, T. M. The dangers of making mint sauce. Contact Dermatitis 2004;51(2):92-93. PubMed
  13. Clayton, R. and Orton, D. Contact allergy to spearmint oil in a patient with oral lichen planus. Contact Dermatitis 2004;51(5-6):314-315. PubMed
  14. Dal Sacco, D., Gibelli, D., and Gallo, R. Contact allergy in the burning mouth syndrome: a retrospective study on 38 patients. Acta Derm.Venereol. 2005;85(1):63-64. PubMed
  15. Goncalves, J. C., Oliveira, Fde S., Benedito, R. B., de Sousa, D. P., de Almeida, R. N., and de Araujo, D. A. Antinociceptive activity of (-)-carvone: evidence of association with decreased peripheral nerve excitability. Biol Pharm Bull. 2008;31(5):1017- PubMed
  16. Ormerod, A. D. and Main, R. A. Sensitisation to "sensitive teeth" toothpaste. Contact Dermatitis 1985;13(3):192-193. PubMed
  17. Skrebova, N., Brocks, K., and Karlsmark, T. Allergic contact cheilitis from spearmint oil. Contact Dermatitis 1998;39(1):35. PubMed
  18. Damiani E, Aloia AM, Priore MG, et al. Allergy to mint (Mentha spicata). J Investig Allergol Clin Immunol 2012;22:309-10.
  19. Connelly AE, Tucker AJ, Tulk H, et al. High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms. J Med Food 2014;17:1361-7. PubMed
  20. Lasrado JA, Nieman KM, Fonseca BA, et al. Safety and tolerability of a dried aqueous spearmint extract. Regul Toxicol Pharmacol 2017;86:167-176. PubMed

See these in context on the Spearmint monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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