Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Stimulant Free Guava Ingredients & Drug Interactions

by Pro-Nutra

Stimulant Free Guava label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stimulant Free Guava against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Stimulant Free Guava is a dietary supplement by Pro-Nutra with 5 active ingredients. Its ingredients are commonly taken for diarrhea and digestive upset, blood sugar support, cholesterol support.Based on those ingredients, 614 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Crocus sativus, Rubus idaeus, Vaccinium angustifolium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Stimulant Free Guava by Pro-Nutra

Ask about any prescription or over-the-counter medication and we check it for interactions with Stimulant Free Guava by Pro-Nutra — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Stimulant Free Guava by Pro-Nutra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “ULTIMATE SUPER FRUIT MATRIX(TM) Proprietary Blend” is a proprietary blend — the label gives one combined amount (385 mg) without saying how much of each component you get.

This product has 5 active ingredients: guava fruit (Psidium guajava), red raspberry leaf (Rubus idaeus), camu camu (Myciaria dubia), saffron (Crocus sativus), and blueberry (Vaccinium angustifolium). They're combined in a proprietary blend, so you won't see the exact amount of each one.

The inactive ingredients—gelatin capsule, microcrystalline cellulose, magnesium stearate, and food colorings—are just there to hold everything together and give the capsule its color.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: weight loss, antioxidant support, blood sugar, skin health.
  • We looked for evidence on: Obesity, Aging skin, Diabetes, Impaired glucose tolerance (prediabetes), Hyperlipidemia, metabolic health — and 2 related terms.
  • The closest evidence on file: Red Raspberry is rated "Insufficient Reliable Evidence To Rate" for Aging skin (Natural Medicines).
  • Also on file: Red Raspberry is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Obesity.
  • Also on file: Saffron is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Hyperlipidemia, Impaired glucose tolerance (prediabetes).

The evidence we have doesn't support most of the uses these ingredients are traditionally marketed for. Guava, red raspberry, and blueberry all show insufficient reliable evidence for claims about blood pressure, blood sugar, diarrhea, gum disease, or joint pain.

Saffron is a bit different: it's possibly effective for chemotherapy-related nerve damage and Alzheimer disease. Blueberry is possibly ineffective for high blood pressure.

In short, if you're buying this mainly for prevention or to manage a chronic condition, the science backing these ingredients is thin.

The evidence, ingredient by ingredient Guava Red Raspberry Camu Camu Saffron Blueberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated when eaten as whole foods—you can eat guava, raspberries, and blueberries without worry. But this product is a concentrated supplement, and the safety data is weaker.

Guava leaf extract may cause stomach pain or nausea, and contact dermatitis if it touches your skin. Red raspberry leaf is thought to be safe for most adults, though there's limited data overall.

Saffron extract can cause nausea, vomiting, and drowsiness at supplement doses, and there's a rare but serious risk of allergic reaction (anaphylaxis). Blueberries are safe as food; freeze-dried blueberry supplements caused gastrointestinal upset in about a quarter of trial participants in one study.

Camu camu lacks sufficient safety data in supplement form. If you're pregnant, avoid saffron and camu camu supplements, as safety isn't established and saffron may stimulate the uterus.

There isn't enough data to know whether red raspberry, guava, or concentrated blueberry extracts are safe in pregnancy—talk with your doctor. For breastfeeding, safety data on high-dose extracts is missing for camu camu and blueberry, and insufficient for red raspberry.

Side effects, ingredient by ingredient Guava Red Raspberry Camu Camu Saffron Blueberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Red Raspberry, Saffron, Blueberry, Guava.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 614 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take antidiabetes drugs or insulin (guava, red raspberry, saffron, and blueberry may lower blood sugar further), blood pressure medication (saffron may lower it more), blood thinners or antiplatelet drugs (red raspberry may increase bleeding risk), sedating drugs like sleep aids or opioids (saffron may add drowsiness), or caffeine pills (saffron may slow how your body clears it). Blueberry may also affect flurbiprofen and buspirone, though these interactions were smaller in human studies than animal research suggested.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This blend might appeal to you if you're looking for a whole-food fruit supplement, but the science supporting its effects is weak for most conditions. The real concern is medication interactions—especially if you take diabetes drugs, blood pressure medication, blood thinners, sedatives, or caffeine pills.

Talk with your pharmacist or doctor before starting, particularly if you're pregnant, breastfeeding, or managing a chronic condition with medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stimulant Free Guava, straight from the product label.

Brand Pro-Nutra
Barcode (UPC) 851330004011
Net contents 60 Cap(s)
Market status On market
Date entered into DSLD Oct 1, 2012
DSLD ID 12428
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stimulant Free Guava by Pro-Nutra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
851330004011
IngredientAmount% DV
Psidium guajava0 NP--
Rubus idaeus0 NP--
Myciaria dubia0 NP--
Crocus sativus0 NP--
Vaccinium angustifolium0 NP--
ULTIMATE SUPER FRUIT MATRIX(TM) Proprietary Blend385 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, FD&C Red No. 3, FD&C Yellow No. 6, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Some of the Benefits of Guava include Supporting Healthy Weight Loss, Antioxidant Properties (ORAC Values), Skin Care and when used as part of your Diet may Promote Healthy Blood Sugar Levels.

FOR MAXIMUM RESULTS COMBINE WITH: METHOXYBURN(TM) 1 CAPSULE IN THE MORNING 1 CAPSULE IN THE AFTERNOON GRP6(TM) 1 CAPSULE 1 HOUR PRIOR TO BEDTIME

When combined with a proper exercise and nutrition regimen. Statements based on early-stage independent 3rd party in vivo and / or in vitro model scientific research data findings.

HEALTHY WEIGHT LOSS The nutrient composition and bio-activity of the Guava fruit support the notion that it is beneficial for regulation of metabolic processes, including energy metabolism, insulin sensitivity, and down-regulation of oxidative stress related fat accumulation.

SUPER ANTIOXIDANT The antioxidant activity of Guava fruit is virtually unrivaled with more than 3.5x greater activity than Pomegranate, 4x greater activity than Apples, more than 16.5x greater activity than Banana, and more than 22x greater activity than Pineapple, by way of example.

"GUAVA may very well be the healthiest fruit on the entire planet. It is the ultimate super fruit with endless benefits. I recommend it to everyone" - Gary I. Weinberger, MD

Raspberry Ketones - Raspberry ketone is a major aromatic compound of red raspberry (Rubus idaeus) and is similar in structure to the two well-known weight management agents, capsaicin and synephrine. Scientific evidence indicates raspberry ketone may enhance energy metabolism and reduce both fat and sugar induced weight gain

PROMOTES WELLNESS & IMPROVED APPEARANCE Emerging research shows that the Guava fruit is a true "Super Fruit", the ultimate "Super Fruit", in fact, with a nutrient composition and bio-activity that is unrivaled by nutritional stalwarts Mango, Apple, Pomegranate, Banana, Watermelon, Grape, Pineapple, etc., for supporting health and wellness.

FEEL GREAT Proper nutrition is a major factor in how one feels, and Guava fruit delivers more milligram-for-milligram nutrition and antioxidant capability than virtually any other "Super Fruit" or "Super Food".

HEALTHY WEIGHT LOSS PROMOTES WELLNESS & IMPROVED APPEARANCE SUPER ANTIOXIDANT FEEL GREAT

SUPER FRUIT HEALTHY WEIGHT LOSS

GUAVA - The New Antioxidant Powerhouse Guava Extract vs. Green Tea Extract (Comparison Study of Antioxidant Bio-Activity) (chart) % Antioxidant Activity GUAVA Ext. GREEN TEA Ext. Concentration (µg/mL) Based on comparative ABTS standard radical in-vitro model, Guava Ext. exerts comparative antioxidant activity as compared to Green Tea Ext., suggesting that Guava Ext. is highly bio-active with potential general health and wellness, and weight management indications, as is the case with Green Tea Ext.

Dr. Gary Weinberger is a member of Pro Nutra’s scientific advisory board.

Guava Extract - Guava fruit delivers more milligram-for-milligram nutrition and antioxidant capability than virtually any other "Super Fruit" or "Super Food".

Saffron Extract - This standardized saffron extract provides support for healthy body weight by targeting some of the emotional factors that make you eat more when you’re trying to eat less.

Blueberry Extract- Blueberries have one of the highest oxygen radical absorbance capacities (ORAC) levels of all fruits and vegetables. Consumption of blueberries may help improve mild memory problems associated with aging. Blueberries are a natural source of vitamin C and specific polyphenols that make blueberries near the top when it comes to antioxidant activity per serving.

Precautions

KEEP OUT OF REACH OF CHILDREN.

DO NOT USE IF SAFETY SEAL IS BROKEN.

Warnings: Not intended for individuals under age of 18, unless instructed by a doctor.

Consult your physician prior to use if you have high blood pressure or heart problems or are taking prescription drugs.

Do not exceed the recommended daily intake. Seek the advice of a healthcare professional before beginning any supplement or exercise program. Improper use of this product will not improve results and is not advised.

Suggested/Recommended/Usage/Directions

Suggested Use: Take one (1) capsule in the morning and one (1) capsule in the afternoon, or as recommended by a qualified healthcare practitioner. This product can be taken with or without food.

FDA Disclaimer Statement

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

General

Rev. 01-001-GUA001 04/12

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stimulant Free Guava by Pro-Nutra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stimulant Free Guava label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stimulant Free Guava by Pro-Nutra

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

ULTIMATE SUPER FRUIT MATRIX(TM) Proprietary Blend

385 mg per serving

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, FD&C Red No. 3, FD&C Yellow No. 6, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stimulant Free Guava by Pro-Nutra Drug Interactions

Want to check YOUR meds against Stimulant Free Guava?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
614Drugs
612 Moderate 2 Minor

Ingredients driving the most interactions

Crocus sativus 521
Rubus idaeus 135
Vaccinium angustifolium 88
Psidium guajava 86

Individual Drug Interactions

The ingredients in Stimulant Free Guava interact with 614 drugs. Click any drug to see the details.

4 of the 5 ingredients in Stimulant Free Guava interact with drugs. Each result below shows which ingredient is responsible. Crocus sativus Rubus idaeus Vaccinium angustifolium Psidium guajava

Each ingredient & the kinds of drugs it affects

For each ingredient in Stimulant Free Guava with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Crocus sativus4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Crocus sativus full monograph & interactions

Rubus idaeus2 drug types · 135 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
In vitro research suggests that red raspberry leaf extract has antiplatelet activity and enhances the in vitro effects of the antiplatelet medication cangrelor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Insulin

Red raspberry leaf might reduce glucose levels in patients being treated with insulin.
In one case report, a 38-year-old patient with gestational diabetes, whose blood glucose was being controlled with medical nutrition therapy and insulin, developed hypoglycemia after consuming two servings of raspberry leaf tea daily for 3 days beginning at 32 weeks' gestation. The patient required an insulin dose reduction. The hypoglycemia was considered to be probably related to use of red raspberry leaf tea.

Likelihood Possible Evidence D
Rubus idaeus full monograph & interactions

Vaccinium angustifolium3 drug types · 88 drugs

Antidiabetes Drugs

Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggests that blueberry and/or blueberry leaf extracts can lower blood glucose levels.

Likelihood Unlikely Evidence D
Buspirone (Buspar)

Theoretically, blueberry juice might increase blood levels of buspirone.
In vitro research shows that blueberry juice can inhibit the metabolism of buspirone, possibly by inhibiting cytochrome P450 3A (CYP3A) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking buspirone hydrochloride 10 mg does not significantly affect the concentration or clearance of buspirone.

Likelihood Unlikely Evidence B
Flurbiprofen (Ansaid, Others)

Theoretically, blueberry juice might increase blood levels of flurbiprofen.
In vitro research shows that blueberry juice can inhibit the metabolism of flurbiprofen, possibly by inhibiting cytochrome P450 2C9 (CYP2C9) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking flurbiprofen 100 mg does not significantly affect the concentration or clearance of flurbiprofen.

Likelihood Unlikely Evidence B
Vaccinium angustifolium full monograph & interactions

Psidium guajava1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, concomitant use with antidiabetes drugs might have additive effects and increase the risk of hypoglycemia. Animal research shows that guava leaf extract or guava fruit can have hypoglycemic effects. Monitor blood glucose levels closely. Medication dose adjustments may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (Diabeta, Glynase PresTab, Micronase), insulin, metformin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence D
Psidium guajava full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stimulant Free Guava, from the product label.

Pro-Nutra

See all Pro-Nutra products
Name
Pro-Nutra
City
Fort Lauderdale
ZipCode
33301
Pharmacist Counseling Corner

Stimulant Free Guava by Pro-Nutra: Common Questions

Does Stimulant Free Guava by Pro-Nutra interact with any medications?
Yes. Based on its ingredients, Stimulant Free Guava has a known interaction with 614 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stimulant Free Guava contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have caffeine in it?
No. The product is called Stimulant Free Guava, and none of the five active ingredients are caffeine. That said, if you already take caffeine pills or drink a lot of coffee, the saffron in this blend might slow how your body processes caffeine, so you could feel more jittery than usual.
Is it safe to take while I'm pregnant?
Not fully. Saffron and camu camu should be avoided in supplement form because safety hasn't been established and saffron may stimulate your uterus. Red raspberry, guava, and blueberry don't have enough data either way—there's no clear yes or no. Talk with your doctor or midwife before taking this product.
What is saffron supposed to do in this blend?
Saffron is the only ingredient here with solid evidence behind it: it's possibly effective for chemotherapy-related nerve pain and Alzheimer disease. The other ingredients—guava, raspberry, blueberry, and camu camu—don't have reliable evidence for the claims often made about them.
Can I take this if I'm on insulin or diabetes medication?
Not without talking to your doctor first. Guava, red raspberry leaf, saffron, and blueberry may all lower blood sugar further, raising the risk of low blood sugar (hypoglycemia). One case report documented someone developing low blood sugar after just three days of raspberry leaf tea. You'll need close monitoring and possibly a dose adjustment.
Does freeze-dried blueberry cause stomach problems?
Yes, it can. In one trial, about a quarter of people taking 50 grams of freeze-dried blueberries daily quit in the first week because of nausea, vomiting, diarrhea, or constipation. We don't know the exact amount of blueberry in this blend, but stomach upset is possible.
Is this safe to take with blood thinners?
Probably, but it's worth checking with your pharmacist. Red raspberry leaf *might* increase bleeding risk on paper, but this hasn't been seen in humans—it's mainly a theoretical concern based on lab work. Still, mention it to your pharmacist or doctor before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stimulant Free Guava label
Go deeper

The Full Monographs Behind Stimulant Free Guava’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Guava

Interacts with 86 drugs

Guava is a tropical fruit tree whose leaves and fruit have a long history of folk use for diarrhea, blood sugar, and general wellness. The fruit is a nutritious food rich in vitamin C, but e...

Read the full Guava monograph → Herb & supplement monograph

Red Raspberry

Interacts with 135 drugs

Red raspberry leaf is a traditional herbal remedy most often used as a tea in late pregnancy and for menstrual discomfort, but solid scientific evidence for these uses is limited. It is gene...

Read the full Red Raspberry monograph → Herb & supplement monograph

Camu Camu

Camu camu is an Amazonian berry that is very high in vitamin C and plant antioxidants, which is why it is popular as an immune and antioxidant supplement. Human research is still limited, so...

Read the full Camu Camu monograph → Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph → Herb & supplement monograph

Blueberry

Interacts with 88 drugs

Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most people. Concentrated supplements are mark...

Read the full Blueberry monograph →
Sources

Sources & How We Checked

Stimulant Free Guava's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 46 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Guava 7 references
  1. Lozoya, X., Reyes-Morales, H., Chavez-Soto, M. A., Martinez-Garcia, Mdel C., Soto-Gonzalez, Y., and Doubova, S. V. Intestinal anti-spasmodic effect of a phytodrug of Psidium guajava folia in the treatment of acute diarrheic disease. J Ethnopharmacol 2002 PubMed
  2. Obi M, Miyazaki Y, Yokozeki H, Nishioka K. Allergic contact dermatitis due to guava tea. Contact Dermatitis. 2001;44(2):116-7. PubMed
  3. Singh RB, Rastogi SS, Singh R, Ghosh S, Niaz MA. Effects of guava intake on serum total and high-density lipoprotein cholesterol levels and on systemic blood pressure. Am J Cardiol. 1992;70(15):1287-91. PubMed
  4. Nayak N, Varghese J, Shetty S, et al. Evaluation of a mouthrinse containing guava leaf extract as part of comprehensive oral care regimen- a randomized placebo-controlled clinical trial. BMC Complement Altern Med. 2019;19(1):327. PubMed
  5. Kakuo S, Fushimi T, Kawasaki K, Nakamura J, Ota N. Effects of Psidium guajava Linn. Leaf extract in Japanese subjects with knee pain: a randomized, double-blind, placebo-controlled, parallel pilot study. Aging Clin Exp Res. 2018;30(11):1391-1398. PubMed
  6. Gutiérrez RM, Mitchell S, Solis RV. Psidium guajava: a review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 2008;117(1):1-27. PubMed
  7. Doubova SV, Morales HR, Hernández SF, et al. Effect of a Psidii guajavae folium extract in the treatment of primary dysmenorrhea: a randomized clinical trial. J Ethnopharmacol. 2007;110(2):305-10. PubMed

See these in context on the Guava monograph →

Red Raspberry 8 references
  1. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  2. Parsons M, Simpson M, Ponton T. Raspberry leaf and its effects on labour: safety and efficacy. Aust Coll Midwives Inc J 1999;12:20-5.
  3. Simpson M, Parsons M, Greenwood J, Wade K. Raspberry leaf in pregnancy: its safety and efficacy in labor. J Midwifery Womens Health 2001;46:51-9.. PubMed
  4. Mullen W, McGinn J, Lean ME, et al. Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. J Agric Food Chem 2002;50:5191-6.. PubMed
  5. Sherson, D., Andersen, B., Hansen, I., and Kjoller, H. Occupational asthma due to freeze-dried raspberry. Ann Allergy Asthma Immunol. 2003;90(6):660-663. PubMed
  6. Cheang KI, Nguyen TT, Karjane NW, Salley KE. Raspberry Leaf and Hypoglycemia in Gestational Diabetes Mellitus. Obstet Gynecol. 2016;128(6):1421-4. PubMed
  7. Dudzinska D, Bednarska K, Boncler M, Luzak B, Watala C. The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils. Platelets. 2016;27(5):433-9.
  8. Henrotin Y, Cozannet RL, Fança-Berthon P, et al. Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial. BMC Musculoskelet Disord 2022;23(1):650. PubMed

See these in context on the Red Raspberry monograph →

Camu Camu 2 references
  1. Vitamin C - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source
  2. Vitamin C — MedlinePlus Source

See these in context on the Camu Camu monograph →

Saffron 22 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Feo F, Martinez J, Martinez A, et al. Occupational allergy in saffron workers. Allergy 1997;52:633-41. PubMed
  5. Wuthrich B, Schmid-Grendelmeyer P, Lundberg M. Anaphylaxis to saffron. Allergy 1997;52:476-7. PubMed
  6. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 2005;19:148-51.
  7. Safarinejad MR, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasth
  8. Fatehi, M., Rashidabady, T., and Fatehi-Hassanabad, Z. Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J Ethnopharmacol. 2003; PubMed
  9. Modaghegh, M. H., Shahabian, M., Esmaeili, H. A., Rajbai, O., and Hosseinzadeh, H. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine. 2008;15(12):1032-1037. PubMed
  10. Imenshahidi, M., Hosseinzadeh, H., and Javadpour, Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother.Res 12-9-2009;
  11. Zhang, Y., Shoyama, Y., Sugiura, M., and Saito, H. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol.Pharm Bull. 1994;17(2):217-221. PubMed
  12. Wuthrich, B., Schmid-Grendelmeyer, P., and Lundberg, M. Anaphylaxis to saffron. Allergy 1997;52(4):476-477. PubMed
  13. Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and plac
  14. Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, Foroughifar T, Salimi S, Akhondzadeh S. Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial. Ph PubMed
  15. Kianbakht S, Ghazavi A. Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial. Phytother Res. 2011 Dec;25(12):1801-5. PubMed
  16. Mazidi M, Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Mokhber N, Ghayour-Mobarhan M, Ferns GA. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J C
  17. Safarinejad MR, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment. Int J Impo PubMed
  18. Talaei A, Hassanpour Moghadam M, Sajadi Tabassi SA, Mohajeri SA. Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial. J Affect Disord. 2 PubMed
  19. Azimi P, Ghiasvand R Feizi A, Hariri M, Abbasi B. Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes. Rev Diabet Stud. 2014 Fall-Winter;11(3-4
  20. Begas E, Bounitsi M, Kilindris T, et al. Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers. Food Chem Toxicol. 2019;130:32-43. PubMed
  21. Moravej Aleali A, Amani R, Shahbazian H, Namjooyan F, Latifi SM, Cheraghian B. The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabet
  22. Abbaszadeh-Mashkani S, Hoque SS, Banafshe HR, Ghaderi A. The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment. Phytother Res. 2021; PubMed

See these in context on the Saffron monograph →

Blueberry 7 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Wang SY, Lin HS. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 2000;48:140-6.. PubMed
  3. Martineau, L. C., Couture, A., Spoor, D., Benhaddou-Andaloussi, A., Harris, C., Meddah, B., Leduc, C., Burt, A., Vuong, T., Mai, Le P., Prentki, M., Bennett, S. A., Arnason, J. T., and Haddad, P. S. Anti-diabetic properties of the Canadian lowbush bluebe
  4. Vuong, T., Martineau, L. C., Ramassamy, C., Matar, C., and Haddad, P. S. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Can J Physiol Pharma
  5. Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 2013 Apr;75(4):1041-52. PubMed
  6. Basu A, Du M, Leyva MJ, et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010;140(9):1582-7. PubMed
  7. Basu A, Feng D, Planinic P, Ebersole JL, Lyons TJ, Alexander JM. Dietary blueberry and soluble fiber supplementation reduces risk of gestational diabetes in women with obesity in a randomized controlled trial. J Nutr 2021;151(5):1128-38. PubMed

See these in context on the Blueberry monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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