Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Rocket Berry Blast Ingredients & Drug Interactions

by Pro-Nutra

Rocket Berry Blast label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rocket Berry Blast against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Rocket Berry Blast is a dietary supplement by Pro-Nutra with 3 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 1,457 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Niacin, Vitamin D3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Rocket Berry Blast by Pro-Nutra

Ask about any prescription or over-the-counter medication and we check it for interactions with Rocket Berry Blast by Pro-Nutra — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Rocket Berry Blast by Pro-Nutra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 11 active ingredients.
  • “Niacin” is listed as a grouped ingredient — the label gives one combined amount (30 mg) without saying how much of each component you get.

Rocket Berry Blast contains 11 active and other ingredients. The active ones include vitamin D3 (for bone health and immune function), caffeine (a stimulant for mental alertness and energy), yohimbe (from tree bark, traditionally used for sexual function and energy), L-carnitine (an amino acid involved in fat and energy metabolism), safflower oil (extracted from seeds), coconut oil, indigofera dupuisii, garcinia (a tropical fruit used in weight-loss blends), and avocado oil.

There's also niacin listed as a blend ingredient, meaning its specific form and amount come from another ingredient in the formula. Two items — an ingredient called "Calorie Burning and Energy Matrix" and nandina — we have no interaction data for.

The powder also contains inactive ingredients (fillers and binders) like maltodextrin, citric acid, malic acid, natural and artificial flavors, sucralose, acesulfame-K, and FD&C Red No. 40 color.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: pre-workout energy and athletic performance support.
  • We looked for evidence on: Athletic performance, Cognitive function, exercise endurance, mental focus, fatigue reduction.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Yohimbe is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Fatigue.
  • Also on file: Garcinia is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence varies widely by ingredient. Vitamin D3 is effective for rickets, osteomalacia (soft bone disease), renal bone disease, and familial hypophosphatemia.

Caffeine is effective for neonatal breathing problems and postoperative headache, and likely effective for mental alertness and athletic performance. For most other active ingredients in this blend — yohimbe, carnitine, safflower oil, garcinia, coconut oil, and avocado oil — the data we hold shows insufficient reliable evidence to rate their effectiveness for weight loss, energy, or other claims that might be made on the product label.

Indigofera dupuisii has no effectiveness ratings in our data.

The evidence, ingredient by ingredient Vitamin D Niacin Caffeine Yohimbe L-carnitine Safflower Coconut Indigo Pulchra

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D3 is generally safe at recommended doses but can cause toxicity at very high doses over time, with symptoms of high blood calcium (hypercalcemia). It's often used in pregnancy under doctor guidance and is generally considered acceptable while breastfeeding at normal amounts.

Caffeine in moderate amounts is usually well tolerated by healthy adults, but high doses can cause anxiety, insomnia, tremors, and rarely, stroke; it's possibly safe in pregnancy at limited amounts and possibly safe while breastfeeding in small quantities. Yohimbe carries more caution — it can cause serious heart and blood pressure effects, is considered unsafe in pregnancy, and should be avoided while breastfeeding.

Carnitine is generally well tolerated but can cause stomach upset and a fishy body odor at high doses; pregnancy safety data are limited, and breastfeeding safety is possibly safe. Safflower oil and garcinia are generally tolerated short-term, though rare liver injury has been reported with garcinia and safflower overuse; both should be avoided in pregnancy and breastfeeding.

Coconut oil and avocado oil are generally safe as foods; concentrated supplements haven't been well studied in pregnancy or breastfeeding. Indigofera dupuisii has no safety data on file, so its safety is unknown and it should be avoided in pregnancy and breastfeeding.

Side effects, ingredient by ingredient Vitamin D Niacin Caffeine Yohimbe L-carnitine Safflower Coconut Indigo Pulchra

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 9 of the 9 matched ingredients can interact with medications — Safflower, Yohimbe, Garcinia, Avocado, Vitamin D, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,453 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use: blood thinners or antiplatelet drugs (warfarin, others); heart rhythm medications (verapamil, diltiazem, digoxin); monoamine oxidase inhibitors or tricyclic antidepressants; blood pressure medications; antidiabetes drugs; epilepsy medications (phenobarbital, carbamazepine); sedatives or barbiturates; antibiotics (especially quinolone fluoroquinolones); or antipsychotics like clozapine. Also check if you take atorvastatin, cimetidine, or dipyridamole.

The caffeine and yohimbe in this product can dangerously amplify the effects of stimulants and certain psychiatric medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is a multi-ingredient blend best suited for healthy adults with no chronic conditions and not taking prescription medications — especially not blood thinners, heart drugs, antidepressants, diabetes medications, or stimulants. If you take any regular medications, have heart or blood pressure problems, or are pregnant or breastfeeding, talk with your doctor or pharmacist before starting, as several ingredients carry documented interactions and the blend contains caffeine, yohimbe, and garcinia, which all have notable safety concerns at higher doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rocket Berry Blast, straight from the product label.

Brand Pro-Nutra
Barcode (UPC) 851330004356
Net contents 5.29 oz.; 150 Gram(s)
Market status On market
Date entered into DSLD Mar 25, 2014
DSLD ID 31631
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rocket Berry Blast by Pro-Nutra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
30
UPC/BARCODE
851330004356
IngredientAmount% DV
Vitamin D32400 IU600%
Niacin30 mg150%
Caffeine0 Not Present--
Yohimbe0 Not Present--
Carnitine0 Not Present--
Safflower Oil0 Not Present--
CALORIE BURNING AND ENERGY MATRIX2100 mg--
Coconut oil0 Not Present--
Indigofera dupuisii0 Not Present--
Garcinia0 Not Present--
Nandina0 Not Present--
Avocado Oil0 Not Present--

Other ingredients: Maltodextrin, Citric Acid, Natural and Artificial flavors, Malic Acid, Sucralose, Acesulfame-K, FD&C Red No. 40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Please read entire label before use. Use only as directed.

Suggested Use: Take one (1) serving (1 scoop) approximately 15-30 minutes prior to training, blended into 6-8 ounces of cold water or beverage, or as suggested by a qualified healthcare practitioner.

Precautions

Do not exceed recommended dose. Do not take more than eight (8) consecutive weeks.

This product should not be taken by pregnant or lactating women. Get the consent of a licensed physician before using this product, especially if you are taking medication, have a medical condition, or thinking about becoming pregnant.

KEEP THIS PRODUCT AND ALL SUPPLEMENTS OUT OF THE REACH OF CHILDREN.

Caffeine warning: The recommended serving of this product contains approximately as much caffeine as three cups of coffee.

Niacin may cause temporary flushing, skin reddening, and sensations of heat, especially if taken on an empty stomach. This is a common reaction.

Contains tree nuts (coconut)

Do not consume caffeine, or combine with synephrine, including but not limited to coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine.

Warning: Not intended for use by person under age 18.

Too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally rapid heartbeat. Discontinue use if you experience dizziness, server headaches, rapid heartbeat or shortness of breath.

Formula

Caffeine warning: The recommended serving of this product contains approximately as much caffeine as three cups of coffee.

Caution: ROCKET(TM) contains the B vitamin niacin.

Natural and Artificial Flavors

Contains tree nuts (coconut)

FDA Disclaimer Statement

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

General Statements

When combined with a proper exercise and nutrition regimen. Statements based one early-stage independent 3rd party in vivo and/or vitro model scientific research data findings for individual ingredients.

EXTREME CALORIE BURNING POWDER May promote WEIGHT LOSS METABOLIC ENHANCEMENT ENERGY & PERFORMANCE PRE-WORKOUT

FDA Statement of Identity

DIETARY SUPPLEMENT

General

Rev-01-001-RKT001 09/13

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rocket Berry Blast by Pro-Nutra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rocket Berry Blast label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rocket Berry Blast by Pro-Nutra

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D3

Interacts with
715 drugs
2400 IU per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

Niacin

Interacts with
727 drugs
30 mg per serving Form: Nicotinic Acid

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

CALORIE BURNING AND ENERGY MATRIX

2100 mg per serving

Other (inactive) ingredients: Maltodextrin, Citric Acid, Natural and Artificial flavors, Malic Acid, Sucralose, Acesulfame-K, FD&C Red No. 40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rocket Berry Blast by Pro-Nutra Drug Interactions

Want to check YOUR meds against Rocket Berry Blast?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,457Drugs
17 Major 1,199 Moderate 241 Minor

Ingredients driving the most interactions

Niacin 727
Vitamin D3 715

Individual Drug Interactions

The ingredients in Rocket Berry Blast interact with 1,457 drugs. Click any drug to see the details.

2 of the 3 ingredients in Rocket Berry Blast interact with drugs. Each result below shows which ingredient is responsible. Niacin Vitamin D3

Each ingredient & the kinds of drugs it affects

For each ingredient in Rocket Berry Blast with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Niacin full monograph & interactions

Vitamin D38 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D3 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rocket Berry Blast, from the product label.

Pro-Nutra

See all Pro-Nutra products
Phone Number
954.513.4530
Web Address
www.pronutra.net
Pharmacist Counseling Corner

Rocket Berry Blast by Pro-Nutra: Common Questions

Does Rocket Berry Blast by Pro-Nutra interact with any medications?
Yes. Based on its ingredients, Rocket Berry Blast has a known interaction with 1,457 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rocket Berry Blast contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have caffeine, and how much?
Yes, caffeine is one of the active ingredients. We don't have the exact dose listed in the product facts, but it's included as a stimulant for energy and mental alertness. If you're sensitive to caffeine or take medications that interact with it, mention that to your pharmacist.
Can I take this if I'm pregnant?
It depends on the ingredient — vitamin D3 is often used in pregnancy under a doctor's guidance, but yohimbe should be avoided, and garcinia and safflower flower are considered possibly or likely unsafe. Because the blend contains multiple ingredients with different pregnancy safety profiles, talk with your doctor or pharmacist before taking it while pregnant.
Can I take this if I'm breastfeeding?
Some ingredients like vitamin D3 and coconut oil are generally fine at normal food amounts, but others like yohimbe have no established safety data, and garcinia and safflower are best avoided. Caffeine passes into breast milk in small amounts — moderate intake is usually considered acceptable but can affect the baby. Check with your doctor or pharmacist about your specific situation.
What does yohimbe do in this product?
Yohimbe is a tree bark traditionally used for energy and sexual function, and it's often included in energy and weight-loss blends. However, we don't have strong evidence that it works for those purposes, and it can raise blood pressure and cause anxiety, tremors, and heart palpitations — especially at higher doses.
Is this safe to take every day?
Caffeine, the main stimulant here, is generally tolerated in moderate daily amounts by healthy adults without prescriptions, but chronic caffeine use can cause dependence and sleep problems. The yohimbe and garcinia components carry more caution with regular use because of potential blood pressure and liver effects. If you want to take this daily, run it by your doctor or pharmacist first, especially if you have any health conditions.
What are the most common side effects?
Caffeine commonly causes anxiety, jitteriness, insomnia, restlessness, and tremors. Yohimbe can cause similar stimulant side effects plus headache, nausea, and elevated heart rate. Garcinia and carnitine may cause gastrointestinal upset like nausea, diarrhea, or stomach cramps. If any of these bother you, stop and talk with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rocket Berry Blast label
Go deeper

The Full Monographs Behind Rocket Berry Blast’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

Yohimbe

Interacts with 1,125 drugs

Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac. A prescription form of yohimbine has some evidence for...

Read the full Yohimbe monograph → Herb & supplement monograph

L-carnitine

Interacts with 19 drugs

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...

Read the full L-carnitine monograph → Herb & supplement monograph

Safflower

Interacts with 208 drugs

Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source of unsaturated fats, but strong proof tha...

Read the full Safflower monograph → Herb & supplement monograph

Coconut

Interacts with 86 drugs

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...

Read the full Coconut monograph → Herb & supplement monograph

Indigo Pulchra

Interacts with 86 drugs

Indigo Pulchra is not a plant or supplement that we can find in any reliable scientific or herbal reference. Because we cannot confirm what it is, what it contains, or whether it is safe, we...

Read the full Indigo Pulchra monograph → Herb & supplement monograph

Garcinia

Interacts with 704 drugs

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific evidence is weak and mixed, with most studies...

Read the full Garcinia monograph → Herb & supplement monograph

Avocado

Interacts with 2 drugs

Avocado is a nutritious fruit rich in healthy monounsaturated fats, fiber, and potassium, and eating it as part of a balanced diet may support heart health. A specific extract called avocado...

Read the full Avocado monograph →
Sources

Sources & How We Checked

Rocket Berry Blast's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 515 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
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  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
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  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
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  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Niacin 66 references
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See these in context on the Niacin monograph →

Caffeine 236 references
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See these in context on the Caffeine monograph →

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Safflower 14 references
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Indigo Pulchra 2 references
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Garcinia 44 references
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Avocado 10 references
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