Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Stress-Relax Pharma GABA Ingredients & Drug Interactions

by Natural Factors

Stress-Relax Pharma GABA label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stress-Relax Pharma GABA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Stress-Relax Pharma GABA is a dietary supplement by Natural Factors with 2 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation.Based on those ingredients, 419 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gamma Amino Butyric Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Stress-Relax Pharma GABA by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with Stress-Relax Pharma GABA by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Stress-Relax Pharma GABA by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: GABA (gamma-aminobutyric acid), a natural compound in your brain that plays a role in relaxation and sleep. The rest is inactive ingredients—cane sugar, stearic acid, silica, natural fruit flavor, citric acid, and magnesium stearate—which are fillers, binders, and flavoring.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gamma-aminobutyric Acid (gaba)'s own graded uses on its monograph.

Why this rating?
  • The label markets this product for: stress relief and relaxation.
  • We looked for evidence on: Anxiety, Insomnia, Hypertension, Depression, Post-traumatic stress disorder (PTSD), Psychological well-being — and 3 related terms.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Depression, Hypertension, Insomnia, Post-traumatic stress disorder (PTSD), and more.

The evidence for GABA isn't established yet. The data we hold shows insufficient reliable evidence to rate it for anxiety, ADHD, athletic performance, chronic bronchitis, or cerebral palsy.

That doesn't mean it doesn't work—it means larger, well-designed studies haven't yet proven it does.

The evidence, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

GABA is generally well tolerated when taken by mouth in the short term, though long-term safety hasn't been studied closely. The most common side effects reported are drowsiness, stomach upset, minor throat burning, muscle weakness, and nausea.

One case report mentioned a temporary stop in menstruation. The product label notes there isn't enough safety information to use it unless your doctor advises it, and breastfeeding is not recommended while taking it.

Side effects, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gamma-aminobutyric Acid (gaba).
  • The most serious interaction on file is rated Moderate.
  • For scale: 419 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use blood pressure medications—GABA may lower your blood pressure further. Also check if you take sedating drugs like sleep aids or certain pain relievers, as GABA might add to their drowsy effects, though the real-world significance isn't clear.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a single-ingredient GABA supplement that's meant to support relaxation. If you take blood pressure medication or any sedating drugs, you'll want to check with your doctor or pharmacist first.

There's not enough evidence yet to say whether it works for anxiety or other conditions. Talk it over with your own healthcare provider before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 10, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stress-Relax Pharma GABA, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958283128
Net contents 10 Chewable Tablet(s)
Market status On market
Date entered into DSLD Oct 10, 2014
DSLD ID 37896
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stress-Relax Pharma GABA by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
5
UPC/BARCODE
068958283128
IngredientAmount% DV
Calories15 {Calories}--
Total Carbohydrates4 Gram(s)1%
Sugar3.5 Gram(s)--
Gamma Amino Butyric Acid200 mg--

Other ingredients: Cane Sugar, Stearic Acid, Silica, natural Fruit flavor, Citric Acid, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Chew 1-2 tablets up to 3 times per day or as directed by a health professional.

Precautions

Keep out of reach of children.

Sealed for your protection. Do not use if seal is broken.

Brand IP Statement(s)

Pharma GABA(R) is a superior source and naturally produced form of the important brain compound Gamma Amino Butyric Acid (GABA). Clinical studies have shown Pharma GABA(R) helps increase the production of alpha brain waves to create a profound sense of physical relaxation while maintaining mental focus.*

Pharma GABA(R) is a registered trademark of Pharma Foods International Co., Ltd. (Japan)

General Statements

All Natural Factors products are manufactured in accordance with the Government of Canada's Good Manufacturing Practices (GMP), among the highest standards in the world.

PRODUCT OF CANADA

Recyclable container and label.

Fast Acting For Mental Colmness & Relaxation* Recommended by Dr. Michael Murray

A tasty fruit flavored chewable tablet.

Formulation

Contains no artificial preservatives, color or sweeteners; no dairy, gluten, soy or wheat.

Storage

For freshness, store in a cool, dry place.

Seals/Symbols

Purity&Potency Guaranteed

FDA Statement of Identity

DIETARY SUPPLEMENT

General

R0

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stress-Relax Pharma GABA by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stress-Relax Pharma GABA label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stress-Relax Pharma GABA by Natural Factors

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container5 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

3.5 Gram(s) per serving

Gamma Amino Butyric Acid

Interacts with
419 drugs
200 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

Gamma Amino Butyric Acid monograph & interactions

Other (inactive) ingredients: Cane Sugar, Stearic Acid, Silica, Natural Fruit flavor, Citric Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stress-Relax Pharma GABA by Natural Factors Drug Interactions

Want to check YOUR meds against Stress-Relax Pharma GABA?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
419Drugs
172 Moderate 247 Minor

Ingredients driving the most interactions

Gamma Amino Butyric Acid 419

Individual Drug Interactions

The ingredients in Stress-Relax Pharma GABA interact with 419 drugs. Click any drug to see the details.

1 of the 2 ingredients in Stress-Relax Pharma GABA interact with drugs. Each result below shows which ingredient is responsible. Gamma Amino Butyric Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Stress-Relax Pharma GABA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gamma Amino Butyric Acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
Gamma Amino Butyric Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stress-Relax Pharma GABA, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Stress-Relax Pharma GABA by Natural Factors: Common Questions

Does Stress-Relax Pharma GABA by Natural Factors interact with any medications?
Yes. Based on its ingredients, Stress-Relax Pharma GABA has a known interaction with 419 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stress-Relax Pharma GABA contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is GABA and what does it do?
GABA (gamma-aminobutyric acid) is a natural compound your brain makes that helps with relaxation and sleep. This supplement provides GABA to try to enhance that effect, though evidence for whether the supplement itself works is still limited.
Can I take this if I'm on blood pressure medication?
GABA may lower blood pressure, so taking it with blood pressure drugs could drop your pressure too far. Talk with your doctor or pharmacist before starting it if you're on a blood pressure medication.
Is this safe to take while pregnant or breastfeeding?
There isn't enough safety data for pregnancy, so talk with your doctor if you're pregnant or planning to become pregnant. Breastfeeding is not recommended while taking this product.
What side effects might I notice?
The most common ones reported are drowsiness, stomach upset, minor throat burning, muscle weakness, and nausea. Overall, GABA is well tolerated, but long-term safety hasn't been thoroughly studied.
Does GABA actually work for anxiety?
The evidence isn't there yet—the data we have rates it as having insufficient reliable evidence for anxiety. That means bigger and better studies would be needed to prove it works.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Stress-Relax Pharma GABA is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stress-Relax Pharma GABA label
Go deeper

The Full Monographs Behind Stress-Relax Pharma GABA’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

Stress-Relax Pharma GABA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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