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Dietary supplement

Super Gymnema 500 mg Ingredients & Drug Interactions

by Best Naturals

Super Gymnema 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Gymnema 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Gymnema 500 mg is a dietary supplement by Best Naturals with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, type 2 diabetes, sugar cravings.Based on those ingredients, 851 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema standardized extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Super Gymnema 500 mg by Best Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Gymnema 500 mg by Best Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super Gymnema 500 mg by Best Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Super Gymnema 500 mg contains one active ingredient: a standardized extract of gymnema. This is a concentrated form of the gymnema plant, calibrated to deliver a consistent dose.

The capsule also contains vegetable cellulose, silica, and vegetable magnesium stearate—inactive ingredients that form the capsule shell and help with absorption.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gymnema's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: maintain healthy blood sugar levels.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Metabolic syndrome, Glucose metabolism, Hyperglycemia.
  • The closest evidence on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Impaired glucose tolerance (prediabetes), Metabolic syndrome.

The evidence for gymnema isn't yet established for the conditions it's marketed for. Our data shows insufficient reliable evidence to rate it for diabetes, obesity, prediabetes (impaired glucose tolerance), or metabolic syndrome.

That doesn't mean it doesn't work—it means large, well-designed human studies haven't been done yet to prove it does. If you're considering this for blood-sugar control or weight, talk with your doctor about whether the current evidence is enough for your situation.

The evidence, ingredient by ingredient Gymnema

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gymnema is generally well tolerated short-term, but there's one serious caution: it can lower your blood sugar, especially if you're on diabetes medication, and the quality of gymnema products varies between manufacturers. Rare cases of liver injury have been reported with gymnema tea taken in high frequency.

The safety data during pregnancy and breastfeeding isn't robust enough, so it's best to avoid this supplement if you're pregnant or nursing—talk with your doctor or pharmacist about whether the data supports your individual use.

Side effects, ingredient by ingredient Gymnema

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gymnema.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 852 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Super Gymnema 500 mg, check with your doctor or pharmacist if you take antidiabetes medications (Moderate risk of low blood sugar), drugs metabolized by CYP1A2, CYP2C9, or CYP3A4 enzymes (Moderate to Minor risk of level changes), or phenacetin or tolbutamide (Moderate risk). Gymnema may raise or lower levels of these drugs depending on the pathway, so your medications may need monitoring or dose adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Super Gymnema 500 mg is a single-ingredient supplement that may appeal to people interested in natural blood-sugar management, but the evidence for it hasn't been established yet. If you take any medications—especially diabetes drugs, birth control, statins, or blood thinners—you need to check with your doctor or pharmacist before starting it, because gymnema can change how your body processes many common drugs.

Pregnant or breastfeeding? Skip it and talk with your healthcare provider about safer options.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Gymnema 500 mg, straight from the product label.

Brand Best Naturals
Barcode (UPC) 817716011615
Net contents 120 Vcap(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 270134
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Gymnema 500 mg by Best Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vcap(s)
Maximum serving Sizes:
1 Vcap(s)
Servings per container
120
UPC/BARCODE
817716011615
IngredientAmount% DV
Gymnema standardized extract500 mg--

Other ingredients: Vegetable Cellulose, Silica, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Gymnema Sylvestre helps maintain healthy blood sugar levels when used as part of your diet. This herb has been used traditionally in India for centuries and has been shown in research to support healthy glucose metabolism.

Super Gymnema (Gymnema Sylvestre Leaf Extract)

Formulation

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no milk, no corn, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

Premium formula

3rd party lab tested

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one (1) capsule one to three times daily with meals or as directed by your qualified healthcare professional.

Precautions

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Storage

Keep in cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

GMP Good Manufacturing Practice Product

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Gymnema 500 mg by Best Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Gymnema 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Gymnema 500 mg by Best Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vcap(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Gymnema standardized extract

Interacts with
851 drugs
500 mg per serving Form: Gymnema sylvestre

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human stu...

Gymnema standardized extract monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Silica, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Gymnema 500 mg by Best Naturals Drug Interactions

Want to check YOUR meds against Super Gymnema 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
851Drugs
347 Moderate 504 Minor

Ingredients driving the most interactions

Gymnema standardized extract 851

Individual Drug Interactions

The ingredients in Super Gymnema 500 mg interact with 851 drugs. Click any drug to see the details.

1 of the 1 ingredient in Super Gymnema 500 mg interact with drugs. Each result below shows which ingredient is responsible. Gymnema standardized extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Gymnema 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gymnema standardized extract6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
Gymnema standardized extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Gymnema 500 mg, from the product label.

Best Naturals

See all Best Naturals products
Name
Best Naturals
Street Address
PO Box 394
City
Kenilworth
State
NJ
ZipCode
07033
Phone Number
1-877-659-6004
Web Address
www.shopbestnaturals.com
Pharmacist Counseling Corner

Super Gymnema 500 mg by Best Naturals: Common Questions

Does Super Gymnema 500 mg by Best Naturals interact with any medications?
Yes. Based on its ingredients, Super Gymnema 500 mg has a known interaction with 851 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Gymnema 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Super Gymnema if I'm on diabetes medication?
No, not without checking with your doctor or pharmacist first. Gymnema lowers blood sugar on its own, and combining it with diabetes drugs could push your blood sugar too low. Your doctor may need to monitor you or adjust your medication dose if you use them together.
Does gymnema actually work for blood sugar or weight loss?
The evidence isn't established yet. Our data shows insufficient reliable evidence to rate gymnema for diabetes, prediabetes, obesity, or metabolic syndrome. That means large human studies haven't proven it works—so talk with your doctor about whether you want to try it anyway.
Is it safe to take while I'm pregnant or breastfeeding?
No, not right now. There isn't enough safety data on gymnema during pregnancy or breastfeeding, so it's best to avoid it if you're pregnant or nursing. Talk with your doctor or pharmacist about safer options for your situation.
What are the side effects?
Gymnema is generally well tolerated short-term. However, rare cases of liver injury—marked by weakness, fatigue, jaundice, and high liver enzymes—have been reported with very frequent use. If you notice any yellowing of skin or eyes, unusual tiredness, or dark urine, stop taking it and call your doctor.
Does this product have any fillers?
Yes, it has a few inactive ingredients that aren't gymnema: vegetable cellulose, silica, and vegetable magnesium stearate. These help form the capsule and make the supplement easier to absorb. If you're sensitive to any of them, check the label or ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Gymnema 500 mg label
Go deeper

The Full Monographs Behind Super Gymnema 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph →
Sources

Sources & How We Checked

Super Gymnema 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gymnema 12 references
  1. Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
  2. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
  3. Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
  4. Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
  5. Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
  6. Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
  7. Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
  8. Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
  9. Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
  10. Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
  11. Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
  12. Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed

See these in context on the Gymnema monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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